{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:21:59Z","timestamp":1774009319691,"version":"3.50.1"},"reference-count":0,"publisher":"Codon Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>Introduction: Proton pump inhibitors (PPIs) are generally well tolerated and are frequently prescribed drugs because their risk of adverse effects is 1\u20133%. Although PPIs have a good safety profile, allergic reactions to these molecules can occur. We aimed to investigate hypersensitivity reactions in patients who underwent oral provocation tests with PPIs in our clinic.\nMethods: In all, 58 subjects who applied to allergy clinic between January 2018 and December 2023 with a history of early allergic reactions with PPIs and subsequently underwent oral provocation testing to find a diagnostic or safe alternative PPI were included in our study. Information on the subjects\u2019 demographic and clinical data and the results of provocation tests was recorded by reviewing patient records.\nResults: Of the 58 subjects included in the study, 44 (75.9%) were females. The mean age of the patients was 54.4 \u00b1 13.8 years. Fifty-three (91.4%) subjects had a history of allergic reactions to a single PPI and 5 (8.6%) subjects had a history of allergic reactions to two different PPIs, such as lansoprazole, pantoprazole, rabeprazole, esomeprazole, and omeprazole. Intradermal skin testing was performed in 51 (87.9%) of the subjects and all were found to be negative. After the provocation test, only two patients (3.4%) developed early-onset hypersensitivity reactions, one with lansoprazole and the other with esomeprazole.\nConclusion: Skin testing is a valuable tool in predicting hypersensitivity reactions associated with PPIs. Although rare, hypersensitivity reactions may occur in patients with negative skin tests.<\/jats:p>","DOI":"10.15586\/aei.v54i2.1537","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:08:10Z","timestamp":1772464090000},"page":"70-75","source":"Crossref","is-referenced-by-count":0,"title":["Hypersensitivity reactions with proton pump inhibitors: five years of clinical experience"],"prefix":"10.15586","volume":"54","author":[{"given":"Melis","family":"Ya\u011fd\u0131ran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-1158","authenticated-orcid":false,"given":"Kurtulu\u015f","family":"Aksu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zg\u00fcr","family":"Akkale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"\u00c7elik Tu\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Telli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Dindar \u00c7elik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcrg\u00fcn Tu\u011f\u00e7e","family":"Vural Solak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6228","published-online":{"date-parts":[[2026,3,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1537\/2302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1537\/2303","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1537\/2304","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1537\/2302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T10:25:54Z","timestamp":1774002354000},"score":1,"resource":{"primary":{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/view\/1537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,3,2]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v54i2.1537","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,1]]}}}