{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:12:44Z","timestamp":1777979564957,"version":"3.51.4"},"reference-count":0,"publisher":"Codon Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>Purpose: House dust mite (HDM) allergy is a common cause of allergic rhinitis (AR) and allergic asthma (AA). Interleukin-27 (IL-27) is known to suppress Th2-mediated inflammation, a key driver of these diseases. This study aimed to assess regional sensitization to\u00a0Dermatophagoides\u00a0subspecies and to investigate the association between HDM-specific IgE responses and serum IL-27 levels.\nMethods: Fifty-eight children with HDM allergy were evaluated, of whom 53 were sensitized to D. Pteronyssinus. Serum Der p 1\/Der p 2 specific IgE (sIgE) (FEIA) and IL-27, IL-5, and IL-13 levels (ELISA) were measured. Twenty-five healthy children served as controls.\nResults: Among patients (43% AR, 57% AA), Der p 1 and Der p 2 sensitization rates were 49% and 55%, respectively. Both Der p 1\/Der p 2 sIgE levels were significantly elevated compared to controls (p &lt; 0.001). Although IL-27 levels were lower in patients, the difference was not statistically significant (p = 0.98). However, IL-27 showed positive correlations with IL-5, IL-13, and Der p 1 sIgE (all p &lt; 0.05). IL-27 levels were unexpectedly higher in Der p 1\u2013sensitized patients (p = 0.006), particularly in AR (p = 0.02; r = 0.43), but not in AA.\nConclusions: This is the first clinical study to investigate the relationship between IL-27 and HDM-sIgE in children and to demonstrate a phenotype-specific interaction. IL-27 may act as a context-dependent immunomodulator rather than a simple Th2 suppressor. The positive correlation between IL-27 and Der p 1 sIgE in AR patients may indicate a compensatory feedback mechanism triggered by allergen-specific inflammation.<\/jats:p>","DOI":"10.15586\/aei.v54i3.1564","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:26:50Z","timestamp":1777642010000},"page":"17-23","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the association between interleukin-27 and\u00a0Dermatophagoides-specific IgE responses in children with allergic rhinitis and asthma"],"prefix":"10.15586","volume":"54","author":[{"given":"Elif","family":"Azarsiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handan","family":"Duman Senol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezgi","family":"Topyildiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"Gulen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esen","family":"Demir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6228","published-online":{"date-parts":[[2026,5,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1564\/2377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1564\/2378","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1564\/2379","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1564\/2377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T10:31:36Z","timestamp":1777977096000},"score":1,"resource":{"primary":{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/view\/1564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v54i3.1564","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]}}}