{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:02:03Z","timestamp":1791820923137,"version":"4.3.4"},"reference-count":0,"publisher":"Codon Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>Background: Atopic dermatitis (AD) is a widespread dermatological condition, particularly affecting children globally. In spite of its high prevalence, comprehensive data on its burden and trends are limited.\nMethods: Using the Global Burden of Disease Study 2021 (GBD 2021) data from 204 countries and 21 regions (1990\u20132021), we analyzed AD prevalence, incidence, and disability-adjusted life years (DALYs), calculating age-standardized rates (ASRs) and estimated annual percentage changes (EAPCs).\nObjective: This study is designed to examine the temporal trends in the burden of AD across global, regional, and national levels.\nResults: Globally, AD cases rose from 107.5 million (1990) to 129.0 million (2021). The high-income Asia Pacific region had instances of age-standardized prevalence (ASPR), age-standardized incidence rate (ASIR), and age-standardized DALYs, with Japan leading among 204 countries. High sociodemographic index (SDI) regions showed the highest ASPR, ASIR, and age-standardized DALYs, while medium and high SDI regions experienced the largest increases. Females exhibited higher ASRs than males. Age-specific prevalence and DALYs peaked in children aged 5\u20139 years, whereas incidence was the highest in those aged under 5 years. Projections based on 1990\u20132021 data suggest declining global trends in ASPR, ASIR, and age-standardized DALYs by 2050.\nConclusions: Global AD prevalence and DALYs continue to rise, whereas ASPR and age-standardized DALYs are declining. High SDI regions exhibit the highest prevalence, yet low-income countries show increasing age-standardized DALYs, underscoring profound regional heterogeneity. Thus, the absolute burden of AD is escalating worldwide, while individual-level risk appears to be improving.<\/jats:p>","DOI":"10.15586\/aei.v54i3.1613","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:20:49Z","timestamp":1777641649000},"page":"102-140","source":"Crossref","is-referenced-by-count":3,"title":["Global, regional, and national burdens of atopic dermatitis from 1990 to 2021: a trend analysis"],"prefix":"10.15586","volume":"54","author":[{"given":"Xiaosong","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya Ju","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","published-online":{"date-parts":[[2026,5,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1613\/2401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1613\/2402","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1613\/2403","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1613\/2401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T10:33:09Z","timestamp":1778409189000},"score":1,"resource":{"primary":{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/view\/1613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v54i3.1613","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]}}}