{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:17:10Z","timestamp":1783509430070,"version":"3.55.0"},"reference-count":0,"publisher":"Codon Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>Introduction: Asparaginase is an integral component in the treatment of acute lymphoblastic leukemia. The asparaginase products available in our country are Escherichia Coli (E. Coli)-derived asparaginase (Leunase), pegaspargase (Oncaspar), and, to a lesser extent,\u00a0Erwinia chrysanthemi-derived asparaginase. Hypersensitivity reactions (HSR) are reported less frequently in those receiving pegaspargase, ranging from 3% to 15%; however, these reactions can limit its use in this population.\nCase report: We present four patients with B-cell ALL who experienced a severe allergic HSR, anaphylaxis, leading us to perform a 12-step desensitization protocol to pegaspargase to ensure that the patients received first-line treatment for their oncologic condition.\nManagement and outcomes: Skin tests were performed, with positive results in two out of four patients. Subsequently, a 12-step desensitization protocol was carried out. Pegaspargase was diluted with 0.9% saline solution in three bags (concentrations 1:100, 1:10, and 1:1). Infusions used four steps per bag titrated every 15 minutes up to a maximum rate of 80 mL\/hour for step 12. A successful administration of pegaspargase was achieved, and the patients continued with their ALL treatment.<\/jats:p>","DOI":"10.15586\/aei.v54i4.1505","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:07:22Z","timestamp":1782940042000},"page":"128-131","source":"Crossref","is-referenced-by-count":0,"title":["Case series of desensitization to pegylated escherichia coli\u2013derived asparaginase: An effective option in response to the need"],"prefix":"10.15586","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4190-5389","authenticated-orcid":false,"given":"Natalhie","family":"Acu\u00f1a Ortega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3612-0042","authenticated-orcid":false,"given":"Sandra N.","family":"Gonz\u00e1lez D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6692-8130","authenticated-orcid":false,"given":"Cindy E.","family":"De Lira Quezada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5145-9143","authenticated-orcid":false,"given":"Ana K.","family":"Ch\u00e1vez Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7933-094X","authenticated-orcid":false,"given":"Julia E.","family":"Colunga Pedraza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5757-7830","authenticated-orcid":false,"given":"Danna S.","family":"R\u00edos Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","published-online":{"date-parts":[[2026,7,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1505\/2494","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1505\/2495","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1505\/2496","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1505\/2494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:40:39Z","timestamp":1783507239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/view\/1505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v54i4.1505","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}