{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T11:15:03Z","timestamp":1783250103661,"version":"3.54.6"},"reference-count":0,"publisher":"Codon Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>Background: Cat sensitization is common in patients with allergic diseases and may not always produce clinical symptoms.\nObjective: This study aimed to assess the correlation between skin prick test (SPT), cat-specific immunoglobulin E (cat sIgE), and symptoms in sensitized children, and to determine optimal thresholds and predictors for clinical cat allergy.\nMethods: We retrospectively evaluated 1052 cat-sensitized children (2017\u20132024) who underwent SPT and\/or cat sIgE testing. Patients were grouped by presence of cat-related symptoms, and their clinical, laboratory, co-sensitization, and exposure characteristics were compared.\nResults: Clinical symptoms developed after exposure in 39% of cat-sensitized patients. The optimal cat sIgE cut-off was 1.05 kU\/L (sensitivity 71.4% and specificity 93.0%), and 4.5 mm for SPT (sensitivity 64.1% and specificity 75.9%). Multivariate analysis identified cat sIgE positivity as the only independent risk factor for symptom development (odds ratio [OR]: 23.22, 95% confidence interval [ 95% CI]: 11.62\u201346.39). Environmental exposure characteristics were significant in univariate analysis; in particular, contact at home (OR: 2.35; 95% CI: 1.48\u20133.71; P &lt; 0.001), family visitation\/indoor contact (OR: 2.99; 95% CI: 1.88\u20134.74; P &lt; 0.001), and sharing a household with a cat (OR: 3.74; 95% CI: 1.78\u20137.85; P &lt; 0.001) were associated with symptom development. Positivity for the house dust mites\u00a0Dermatophagoides farinae\u00a0(OR: 1.59; P &lt; 0.001) and\u00a0Dermatophagoides pteronyssinus\u00a0(OR: 1.65; P &lt; 0.001) and grass pollen sensitization (OR: 1.69; P &lt; 0.001) were also significantly associated with symptomatic patients.\nConclusions: Cat sIgE positivity independently predicts symptoms, with 1.05 kU\/L for sIgE and 4.5 mm for SPT identified as reliable diagnostic cut-offs.<\/jats:p>","DOI":"10.15586\/aei.v54i4.1617","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:57:09Z","timestamp":1782939429000},"page":"11-19","source":"Crossref","is-referenced-by-count":0,"title":["Beyond sensitization: real-life thresholds for cat allergy in children"],"prefix":"10.15586","volume":"54","author":[{"given":"G\u00fcler","family":"Y\u0131ld\u0131r\u0131m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilay","family":"\u00c7al\u0131\u015fkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Karaca \u015eahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamit","family":"Bolo\u011fur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Fatih Erbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"G\u00fcng\u00f6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eefika \u0130lknur","family":"K\u00f6k\u00e7\u00fc Karada\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131 Berivan","family":"Top\u00e7ak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Tun\u00e7","family":"\u015earman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Terzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"\u00d6z\u00e7eker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","published-online":{"date-parts":[[2026,7,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1617\/2452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1617\/2453","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1617\/2454","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1617\/2452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T10:40:22Z","timestamp":1783248022000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/view\/1617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v54i4.1617","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}