{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:07:02Z","timestamp":1789556822765,"version":"build-2803163510"},"reference-count":0,"publisher":"Codon Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>Background: Chronic spontaneous urticaria (CSU) is a systemic immune-mediated disorder frequently comorbid with autoimmune thyroid disease, particularly Hashimoto\u2019s thyroiditis (HT). Emerging evidence implicates shared immunogenetic pathways, yet the role of thymic stromal lymphopoietin (TSLP), a key epithelial alarmin in this comorbidity remains unclear.\nObjective: To investigate the association between TSLP SNPs and the co-occurrence of CSU and HT.\nMethods: We enrolled 45 patients with CSU alone and 41 with CSU and concomitant HT from a reference center in the Colombian Caribbean. Diagnosis of HT was based on clinical, ultrasonographic, serological (anti-TPO &gt;35 IU\/mL), and biochemical criteria. Genotyping of TSLP SNPs rs1837253, rs2289276, and rs17551370 was performed using TaqMan\u00ae assays.\nResults: The rs17551370 GG genotype was significantly more prevalent in the CSU+HT group (88% vs. 71%; OR = 3.84, 95% CI: 1.21\u201312.2; p = 0.02). Conversely, the rs2289276 TT genotype was less frequent in the CSU+HT group (2.4% vs. 18%; OR = 0.11, 95% CI: 0.02\u20130.74; p = 0.02), suggesting a protective effect. Carriers of the CCG haplotype (Ht1) exhibited a 2.11-fold increased odds of presenting concomitant HT among patients with CSU (OR = 2.11; 95% CI: 1.11\u20134.01; p = 0.02).\nConclusions: TSLP promoter variants rs17551370 and rs2289276 are significantly associated with CSU-HT comorbidity, supporting a shared pathogenic mechanism driven by dysregulated alarmin signaling and Th2\/Th17 inflammation. These findings highlight TSLP as a potential genetic marker and therapeutic target in autoimmune urticaria.<\/jats:p>","DOI":"10.15586\/aei.v54i5.1606","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:06:45Z","timestamp":1788278805000},"page":"10-17","source":"Crossref","is-referenced-by-count":0,"title":["Genetic variation in the TSLP promoter is associated with Hashimoto\u2019s thyroiditis comorbidity in patients with chronic spontaneous urticaria"],"prefix":"10.15586","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7548-1257","authenticated-orcid":false,"given":"Eduardo","family":"Egea-Bermejo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4986-6118","authenticated-orcid":false,"given":"Luis","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4273-0609","authenticated-orcid":false,"given":"Carlos","family":"Octavio Arroyo-Movilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3984-8653","authenticated-orcid":false,"given":"Alex","family":"Dom\u00ednguez-Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8747-5268","authenticated-orcid":false,"given":"Ana","family":"Moreno-Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9425-0208","authenticated-orcid":false,"given":"Gloria","family":"Garavito De Egea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","published-online":{"date-parts":[[2026,9,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1606\/2524","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1606\/2525","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1606\/2526","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1606\/2524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:51:01Z","timestamp":1789555861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/view\/1606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v54i5.1606","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}