{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:07:04Z","timestamp":1789556824050,"version":"build-2803163510"},"reference-count":0,"publisher":"Codon Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>Background: Asthma exacerbations (AE) impose a significant burden on children and the healthcare systems, highlighting the need for objective biomarkers and functional assessment tools.\nObjective: This study aimed to evaluate serum endocan levels and respiratory function parameters during AE and the post-recovery (PR) period, and to compare the results with healthy controls.\nMaterials and Methods: In this prospective longitudinal observational study, children aged 6\u201318 years were evaluated during AE (n = 66), 1 month after recovery (PR group, n = 54), and as age- and gender-matched healthy controls (HC, n = 50). All participants underwent spirometry, impulse oscillometry (IOS), and serum endocan measurement.\nResults: Serum endocan levels were significantly higher in the AE group than in the PR and HC groups [267.33 (186.68\u2013370.20) vs. 133.07 (38.26\u2013226.78) and 118.11 (42.93\u2013180.20) pg\/mL, respectively; P &lt; 0.001]. Spirometric indices, including zFEV1, zFVC, zFEV1\/FVC, and zFEF25\u201375, were significantly lower in the AE group than in both comparison groups (all P &lt; 0.05). Compared to healthy controls, children in the AE group exhibited higher R5\u201320, Fres, and AX values and lower zX20 values (all P \u2264 0.002). R5\u201320 remained significantly higher during AE than in the PR period (P = 0.038), while spirometric indices showed significant improvement after recovery (all P &lt; 0.05). Notably, despite normalization of spirometric parameters and serum endocan levels, the PR group continued to exhibit higher R5\u201320 and AX values and lower zX20 values than healthy controls (all P &lt; 0.05), suggesting persistent small-airway dysfunctioning. Serum endocan levels showed weak-to-moderate negative correlations with zFEF25\u201375, zFEV1, and zFEV1\/FVC (Spearman\u2019s rho = -0.306, -0.291, and -0.223, respectively; all P \u2264 0.013).\nConclusion: These findings suggest that serum endocan is associated with airway dysfunctioning and may reflect disease activity during pediatric AE, while IOS may provide additional information regarding persistent small-airway involvement after recovery.<\/jats:p>","DOI":"10.15586\/aei.v54i5.1786","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:55:17Z","timestamp":1788278117000},"page":"47-57","source":"Crossref","is-referenced-by-count":0,"title":["Elevated serum endocan levels and impaired respiratory functions in childhood asthma: a comparative study"],"prefix":"10.15586","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0587-5220","authenticated-orcid":false,"given":"Simge","family":"Atar Bese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclten","family":"Tuncerler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihangir","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur","family":"Torer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"\u00c7evik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Uysal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Erge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","published-online":{"date-parts":[[2026,9,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1786\/2539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1786\/2540","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1786\/2541","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/1786\/2539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:51:42Z","timestamp":1789555902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/view\/1786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v54i5.1786","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}