{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:57:19Z","timestamp":1773021439821,"version":"3.50.1"},"reference-count":0,"publisher":"Codon Publications","issue":"4","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Popl Ther Clin Pharmacol"],"abstract":"<jats:p>The use of maternal antiepileptic drug (AED) during pregnancy is associated with an increased risk of cognitive adverse effects among the offspring. As new-generation AEDs continue to enter the market, evidence on their safety during pregnancy is limited yet necessary. To date, there are no published reviews summarizing the evidence of new-generation AED exposure in utero and the development of attention deficit-hyperactivity disorder (ADHD) in the offspring. The objective of this scoping review is to summa-rize the available evidence on the risk of ADHD after maternal exposure to new-generation AEDs during pregnancy. We searched EMBASE and MEDLINE for articles published from January 1988 to April 2020. New-generation AEDs were considered if marketed after 1988. ADHD was defined as attention-deficit hyperac-tivity disorder, hyperkinetic disorder, hyperkinesis, or conduct disorder. Of the total articles screened (n = 805), eight publications were finally included (seven cohort studies and one systematic review). Across the studies, the sample size of pregnant women exposed to AEDs ranged from 1 to 1383. Monotherapy was examined in six studies (mostly lamotrigine), while only two studies examined polytherapy. The included studies reported a range of adjusted relative risks, from 0.84 [0.59\u2013 1.19] to 1.63 [0.41\u20136.06]. Lamotrigine monotherapy holds the largest body of evidence, concluding that no significant risk of ADHD exists among the offspring. However, the available evidence is considered scarce and has several method-ological limitations. Disentangling the effect of AEDs from epilepsy itself and examining polytherapies are challenges that merit additional investigations. Further comparative safety studies with longer follow-up periods and large sample sizes are needed to accurately quantify the true impact of new-generation AED exposure during pregnancy and ADHD in children.<\/jats:p>","DOI":"10.15586\/jptcp.v27i4.722","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T13:23:07Z","timestamp":1602854587000},"page":"e1-e18","source":"Crossref","is-referenced-by-count":9,"title":["New-generation antiepileptic drugs during pregnancy and the risk of  attention-deficit hyperactivity disorder"],"prefix":"10.15586","volume":"27","author":[{"given":"Christine","family":"Vaccaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Shakeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Czaplinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif","family":"Eltonsy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6228","published-online":{"date-parts":[[2020,10,14]]},"container-title":["Journal of Population Therapeutics and Clinical Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/jptcp.com\/index.php\/jptcp\/article\/download\/722\/728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jptcp.com\/index.php\/jptcp\/article\/download\/722\/729","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jptcp.com\/index.php\/jptcp\/article\/download\/722\/730","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jptcp.com\/index.php\/jptcp\/article\/download\/722\/728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:51:40Z","timestamp":1634345500000},"score":1,"resource":{"primary":{"URL":"https:\/\/jptcp.com\/index.php\/jptcp\/article\/view\/722"}},"subtitle":["A scoping review"],"short-title":[],"issued":{"date-parts":[[2020,10,14]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,10,15]]}},"URL":"https:\/\/doi.org\/10.15586\/jptcp.v27i4.722","relation":{},"ISSN":["1710-6222","1198-581X"],"issn-type":[{"value":"1710-6222","type":"electronic"},{"value":"1198-581X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,14]]}}}