{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:05:37Z","timestamp":1777471537064,"version":"3.51.4"},"reference-count":22,"publisher":"Journal of the ASEAN Federation of Endocrine Societies (JAFES)","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J ASEAN Fed Endocr Soc"],"abstract":"<jats:p>Objective. This study determined the incidence of perioperative complications associated with routine preoperative glucocorticoid use in patients undergoing pituitary surgery with normal preoperative hypothalamo-pituitary-adrenal axis (HPA axis).\nMethodology. From 2011-2021 retrospective chart review, 243 patients undergoing pituitary surgery with normal preoperative HPA axis were analyzed into 2 groups: 1) with preoperative steroids and 2) without preoperative steroids. \u00a0Development of postoperative complications was subsequently evaluated.\nResults. Incidence of primary composite postoperative complications of in-hospital mortality, postoperative infection and postoperative diabetes insipidus (DI) was significantly increased among those who had preoperative steroids compared to those without (58.33% versus 33.33%, p-value 0.004)\u00a0 with an adjusted odds ratio of 2.90 (CI 1.29 to 6.53, p-value 0.010). Among the components of the composite outcome, post-operative DI was statistically higher among those who were given preoperative steroids (52.45% versus 28.21%, p-value 0.006) with an adjusted OR of 3.31 (CI 1.43 to 7.67, p-value 0.005). The incidence of postoperative adrenal insufficiency was similar between the 2 groups (20.15% with steroids versus 8.70% without steroids, p-value 0.258).\nConclusion. Among patients undergoing pituitary surgery with normal preoperative HPA axis, routine preoperative steroids use was associated with an increased risk of composite postoperative complications. \u00a0<\/jats:p>","DOI":"10.15605\/jafes.040.01.06","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T07:40:04Z","timestamp":1745912404000},"source":"Crossref","is-referenced-by-count":1,"title":["Perioperative Complications Associated with Routine Preoperative Glucocorticoid Use among Patients undergoing Pituitary Surgery with Normal Preoperative HPA Axis"],"prefix":"10.15605","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3320-6155","authenticated-orcid":false,"given":"Franz Michael","family":"Magnaye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Paz-Pacheco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6244","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"71255","doi-asserted-by":"crossref","unstructured":"1. 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Glucocorticoid replacement in pituitary surgery: Guidelines for perioperative assessment and management. J Clin Endocrinol Metab. 2002;87(6):2745-50. https:\/\/pubmed.ncbi.nlm.nih.gov\/12050244 https:\/\/doi.org\/10.1210\/jcem.87.6.8547","DOI":"10.1210\/jcem.87.6.8547"},{"key":"71261","doi-asserted-by":"crossref","unstructured":"4. Garcia-Luna PP, Leal-Cerro A, Rocha JL, Trujillo F, Garcia-Pesquera F, Astorga R Evaluation of the pituitary-adrenal axis before, during and after pituitary adenomectomy. Is perioperative glucocorticoid therapy necessary? Acta Endocrinol (Copenh). 1990;122(1):83-8. https:\/\/pubmed.ncbi.nlm.nih.gov\/2154904 https:\/\/doi.org\/10.1530\/acta.0.1220083","DOI":"10.1530\/acta.0.1220083"},{"key":"71263","doi-asserted-by":"crossref","unstructured":"5. Prete A, Corsello SM, Salvatori R. Current best practice in the management of patients after pituitary surgery. 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J Clin Endocrinol Metab. 2008;93(11):4245-53. https:\/\/pubmed.ncbi.nlm.nih.gov\/18697868 https:\/\/doi.org\/10.1210\/jc.2008-0710","DOI":"10.1210\/jc.2008-0710"},{"key":"71281","doi-asserted-by":"crossref","unstructured":"14. Turina M, Miller FN, Tucker CF, Polk HC. Short-term hyperglycemia in surgical patients and a study of related cellular mechanisms. Ann Surg. 2006; 243(6):845\u201353. https:\/\/pubmed.ncbi.nlm.nih.gov\/16772788 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1570574 https:\/\/doi.org\/10.1097\/01.sla.0000220041.68156.67","DOI":"10.1097\/01.sla.0000220041.68156.67"},{"key":"71283","doi-asserted-by":"crossref","unstructured":"15. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. 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Duration of cortisol suppression following a single dose of dexamethasone in healthy volunteers: A randomised double-blind placebo-controlled trial. Anaesth Intensive Care. 2013;41(5):596\u2013601. https:\/\/pubmed.ncbi.nlm.nih.gov\/23977910 https:\/\/doi.org\/10.1177\/0310057X1304100504","DOI":"10.1177\/0310057X1304100504"}],"container-title":["Journal of the ASEAN Federation of Endocrine Societies"],"original-title":[],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T07:40:13Z","timestamp":1745912413000},"score":1,"resource":{"primary":{"URL":"https:\/\/asean-endocrinejournal.org\/index.php\/JAFES\/article\/view\/3133"}},"subtitle":["A Retrospective Cohort Study"],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":22,"URL":"https:\/\/doi.org\/10.15605\/jafes.040.01.06","relation":{},"ISSN":["2308-118X","0857-1074"],"issn-type":[{"value":"2308-118X","type":"electronic"},{"value":"0857-1074","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,24]]}}}