{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T02:18:31Z","timestamp":1769566711368,"version":"3.49.0"},"reference-count":25,"publisher":"Journal of the ASEAN Federation of Endocrine Societies (JAFES)","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J ASEAN Fed Endocr Soc"],"abstract":"<jats:p>Background. Bisphenol A (BPA) is a widely used industrial element. Recently it is suspected that BPA may disrupt the endocrine system to influence the manifestations of polycystic ovary syndrome (PCOS).\nObjective. This study aimed to assess serum BPA level and its association with manifestations of PCOS in women.\nMethodology. This cross-sectional study included 40 young adults with PCOS and 38 age-matched control women [23.0 (20.0, 29.0) vs. 25.0 (21.0, 29.0), years, median (IQR), p = 0.406]. After a thorough clinical examination, fasting blood was collected in the follicular phase of the menstrual cycle to measure glucose, lipids, insulin, luteinizing hormone, follicle-stimulating hormone, total testosterone, sex hormone binding globulin, dehydroepiandrosterone sulfate, and BPA. Glucose was measured by glucose oxidase, lipids by glycerol phosphate dehydrogenase-peroxidase, all hormones including SHBG by chemiluminescent immunoassay and BPA by sandwiched enzyme-linked immunosorbent assay. Insulin resistance was measured using homeostasis model assessment of insulin resistance.\nResult. Women with PCOS had significantly higher BPA levels (ng\/mL) than the control group [27.30 (25.60, 33.40) vs. 24.0 (15.58, 28.70), median (IQR), p = 0.001]. Using the 75th percentile value of the control group, 15 (37.5%) women with PCOS had high BPA levels. Those with high BPA levels had a significantly higher frequency of menstrual regulation \/abortion among women with PCOS [53.8% vs. 0%, p=0.005]. Women with PCOS with a history of menstrual regulation \/ abortion [36.7 \u00b1 4.9 vs. 28.5 \u00b1 6.4, mean \u00b1 SD, p = 0.004] and subfertility [34.3 \u00b1 6.8 vs. 28.5 \u00b1 6.4, mean \u00b1 SD, p = 0.031] had higher levels of BPA than those without the histories. Serum BPA had no significant association or correlation with any androgenic and metabolic manifestations.\nConclusion. Raised BPA level may be associated with adverse reproductive features in PCOS.<\/jats:p>","DOI":"10.15605\/jafes.040.01.14","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T07:39:53Z","timestamp":1745912393000},"source":"Crossref","is-referenced-by-count":1,"title":["Raised Bisphenol A has a Significant Association with Adverse Reproductive Manifestations rather than Biochemical or Hormonal Aberrations in Women with Polycystic Ovary Syndrome"],"prefix":"10.15605","author":[{"given":"Emran-Ur-Rashid","family":"Chowdhury","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8115-1761","authenticated-orcid":false,"given":"Hurjahan","family":"Banu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6115-2655","authenticated-orcid":false,"given":"Md","family":"Shahed-Morshed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4970-3482","authenticated-orcid":false,"given":"Iffat Ara","family":"Jahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8613-1399","authenticated-orcid":false,"given":"Subi","family":"Kharel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8151-9792","authenticated-orcid":false,"given":"Muhammad Abul","family":"Hasanat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6244","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"71205","doi-asserted-by":"crossref","unstructured":"1. Casarini L, Brigante G. The polycystic ovary syndrome evolutionary paradox: A genome-wide association studies-based, in silico, evolutionary explanation. J Clin Endocrinol Metab. 2014;99(11):E2412-20. https:\/\/pubmed.ncbi.nlm.nih.gov\/25093623 https:\/\/doi.org\/10.1210\/jc.2014-2703","DOI":"10.1210\/jc.2014-2703"},{"key":"71207","doi-asserted-by":"crossref","unstructured":"2. Kshetrimayum C, Sharma A, Mishra VV, Kumar S. Polycystic ovarian syndrome: Environmental\/occupational, lifestyle factors; An overview. J Turk Ger Gynecol Assoc. 2019;20(4):255-6. https:\/\/pubmed.ncbi.nlm.nih.gov\/30821135 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6883751 https:\/\/doi.org\/10.4274\/jtgga.galenos.2019.2018.01423","DOI":"10.4274\/jtgga.galenos.2019.2018.0142"},{"key":"71209","doi-asserted-by":"crossref","unstructured":"3. Almeida S, Raposo A, Almeida-Gonz\u00e1lez M, Carrascosa C. Bisphenol A: Food exposure and impact on human health. Compr Rev Food Sci Food Saf. 2018;17(6):1503-17. https:\/\/pubmed.ncbi.nlm.nih.gov\/33350146 https:\/\/doi.org\/10.1111\/1541-4337.12388","DOI":"10.1111\/1541-4337.12388"},{"key":"71211","doi-asserted-by":"crossref","unstructured":"4. Rutkowska A, Racho\u0144 D. Bisphenol A (BPA) and its potential role in the pathogenesis of the polycystic ovary syndrome (PCOS). Gynecol Endocrinol. 2014;30(4):260-5. https:\/\/pubmed.ncbi.nlm.nih.gov\/24397396 https:\/\/doi.org\/10.3109\/09513590.2013.871517","DOI":"10.3109\/09513590.2013.871517"},{"key":"71213","doi-asserted-by":"crossref","unstructured":"5. Palioura E, Kandaraki E, Diamanti-Kandarakis E. Endocrine disruptors and polycystic ovary syndrome: A focus on bisphenol A and its potential pathophysiological aspects. Horm Mol Biol Clin Investig. 2014;17(3):137-44. https:\/\/pubmed.ncbi.nlm.nih.gov\/25372737 https:\/\/doi.org\/10.1515\/hmbci-2014-0003","DOI":"10.1515\/hmbci-2014-0003"},{"key":"71215","doi-asserted-by":"crossref","unstructured":"6. Kechagias KS, Semertzidou A, Athanasiou A, Paraskevaidi M, Kyrgiou M. Bisphenol-A and polycystic ovary syndrome: A review of the literature. Rev Environ Health. 2020;35(4):323-31. https:\/\/pubmed.ncbi.nlm.nih.gov\/32663175 https:\/\/doi.org\/10.1515\/reveh-2020-0032","DOI":"10.1515\/reveh-2020-0032"},{"key":"71217","doi-asserted-by":"crossref","unstructured":"7. Fowler PA, Bellingham M, Sinclair KD, et al. Impact of endocrine-disrupting compounds (EDCs) on female reproductive health. Mol Cell Endocrinol. 2012;355(2):231-9. https:\/\/pubmed.ncbi.nlm.nih.gov\/22061620 https:\/\/doi.org\/10.1016\/j.mce.2011.10.021","DOI":"10.1016\/j.mce.2011.10.021"},{"key":"71219","doi-asserted-by":"crossref","unstructured":"8. Kandaraki E, Chatzigeorgiou A, Livadas S, et al. Endocrine disruptors and polycystic ovary syndrome (PCOS): Elevated serum levels of bisphenol A in women with PCOS. J Clin Endocrinol Metab. 2011;96(3):E480-4. https:\/\/pubmed.ncbi.nlm.nih.gov\/21193545 https:\/\/doi.org\/10.1210\/jc.2010-1658","DOI":"10.1210\/jc.2010-1658"},{"key":"71221","doi-asserted-by":"crossref","unstructured":"9. Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19-25. https:\/\/pubmed.ncbi.nlm.nih.gov\/14711538 https:\/\/doi.org\/10.1016\/j.fertnstert.2003.10.004","DOI":"10.1093\/humrep\/deh098"},{"key":"71223","doi-asserted-by":"crossref","unstructured":"10. Escobar-Morreale HF, Carmina E, Dewailly D, Gambineri A, Kelestimur F, Moghetti P, et al. Epidemiology, diagnosis and management of hirsutism: A consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society. Hum Reprod Update. 2012;18(2):146-70. https:\/\/pubmed.ncbi.nlm.nih.gov\/22064667 https:\/\/doi.org\/10.1093\/humupd\/dmr042","DOI":"10.1093\/humupd\/dmr042"},{"key":"71225","unstructured":"11. World Health Organization. Regional Office for the Western Pacific\u200e. The Asia-Pacific perspective: redefining obesity and its treatment. Sydney: Health Communications Australia; 2000. https:\/\/apps.who.int\/iris\/handle\/10665\/206936"},{"key":"71227","doi-asserted-by":"crossref","unstructured":"12. Hahn S, Kuehnel W, Tan S, et al. Diagnostic value of calculated testosterone indices in the assessment of polycystic ovary syndrome. Clin Chem Lab Med. 2007;45(2):202-7. https:\/\/pubmed.ncbi.nlm.nih.gov\/17311509 https:\/\/doi.org\/10.1515\/CCLM.2007.031","DOI":"10.1515\/CCLM.2007.031"},{"key":"71229","doi-asserted-by":"crossref","unstructured":"13. Laz\u00farov\u00e1 Z, Figurov\u00e1 J, Hubkov\u00e1 B, Ma\u0161lankov\u00e1 J, Laz\u00farov\u00e1 I. Urinary bisphenol A in women with polycystic ovary syndrome - a possible suppressive effect on steroidogenesis? Horm Mol Biol Clin Investig. 2021;42(3):303-9. https:\/\/pubmed.ncbi.nlm.nih.gov\/34118794 https:\/\/doi.org\/10.1515\/hmbci-2020-0032","DOI":"10.1515\/hmbci-2020-0032"},{"key":"71231","unstructured":"14. Hossein Rashidi B, Amanlou M, Behrouzi Lak T, et al. The association between bisphenol A and polycystic ovarian syndrome: A case-control study. Acta Med Iran. 2017;55(12):759-64. https:\/\/pubmed.ncbi.nlm.nih.gov\/29373882"},{"key":"71233","doi-asserted-by":"crossref","unstructured":"15. Konieczna A, Racho\u0144 D, Owczarek K, et al. Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome. Reprod Toxicol. 2018;82:32-7. https:\/\/pubmed.ncbi.nlm.nih.gov\/30266220 https:\/\/doi.org\/10.1016\/j.reprotox.2018.09.006","DOI":"10.1016\/j.reprotox.2018.09.006"},{"key":"71235","doi-asserted-by":"crossref","unstructured":"16. Hu Y, Wen S, Yuan D, et al. The association between the environmental endocrine disruptor bisphenol A and polycystic ovary syndrome: A systematic review and meta-analysis. Gynecol Endocrinol. 2018;34(5):370-7. https:\/\/pubmed.ncbi.nlm.nih.gov\/29191127 https:\/\/doi.org\/ 10.1080\/09513590.2017.1405931","DOI":"10.1080\/09513590.2017.1405931"},{"key":"71237","unstructured":"17. Li TT, Xu LZ, Chen YH, et al. Effects of eight environmental endocrine disruptors on insulin resistance in patients with polycystic ovary syndrome: A preliminary investigation. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31(10):1753-6. https:\/\/pubmed.ncbi.nlm.nih.gov\/ 22027783"},{"key":"71239","doi-asserted-by":"crossref","unstructured":"18. Vagi SJ, Azziz-Baumgartner E, Sj\u00f6din A, et al. Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol A in polycystic ovary syndrome: A case-control study. BMC Endocr Disord. 2014;14:86. https:\/\/pubmed.ncbi.nlm.nih.gov\/25348326 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4287339 https:\/\/doi.org\/10.1186\/1472-6823-14-86","DOI":"10.1186\/1472-6823-14-86"},{"key":"71241","doi-asserted-by":"crossref","unstructured":"19. Tarantino G, Valentino R, Di Somma C, et al. Bisphenol A in polycystic ovary syndrome and its association with liver-spleen axis. Clin Endocrinol (Oxf). 2013;78(3):447-53. https:\/\/pubmed.ncbi.nlm.nih.gov\/22805002 https:\/\/doi.org\/10.1111\/j.1365-2265.2012.04500.x","DOI":"10.1111\/j.1365-2265.2012.04500.x"},{"key":"71243","doi-asserted-by":"crossref","unstructured":"20. Tsutsumi O. Assessment of human contamination of estrogenic endocrine-disrupting chemicals and their risk for human reproduction. J Steroid Biochem Mol Biol 2005;93(2-5):325\u201330. https:\/\/pubmed.ncbi.nlm.nih.gov\/15860277 https:\/\/doi.org\/10.1016\/j.jsbmb.2004.12.008","DOI":"10.1016\/j.jsbmb.2004.12.008"},{"key":"71245","doi-asserted-by":"crossref","unstructured":"21. Takai Y, Tsutsumi O, Ikezuki Y, et al. Estrogen receptor-mediated effects of a xenoestrogen, bisphenol A, on preimplantation mouse embryos. Biochem Biophys Res Commun. 2000;270(3):918-21. https:\/\/pubmed.ncbi.nlm.nih.gov\/10772925 https:\/\/doi.org\/10.1006\/bbrc.2000.2548","DOI":"10.1006\/bbrc.2000.2548"},{"key":"71247","doi-asserted-by":"crossref","unstructured":"22. Jurewicz J, Majewska J, Berg A, et al. Serum bisphenol A analogues in women diagnosed with the polycystic ovary syndrome - is there an association? Environ Pollut. 2021;272:115962. https:\/\/pubmed.ncbi.nlm.nih.gov\/33223334 https:\/\/doi.org\/10.1016\/j.envpol.2020.115962","DOI":"10.1016\/j.envpol.2020.115962"},{"key":"71249","doi-asserted-by":"crossref","unstructured":"23. Akg\u00fcl S, Sur \u00dc, D\u00fcz\u00e7eker Y, et al. Bisphenol A and phthalate levels in adolescents with polycystic ovary syndrome. Gynecol Endocrinol. 2019;35(12):1084-7. https:\/\/pubmed.ncbi.nlm.nih.gov\/31219355 https:\/\/doi.org\/10.1080\/09513590.2019.1630608","DOI":"10.1080\/09513590.2019.1630608"},{"key":"71251","doi-asserted-by":"crossref","unstructured":"24. Kawa IA, Masood A, Ganie MA, et al. Bisphenol A (BPA) acts as an endocrine disruptor in women with polycystic ovary syndrome: Hormonal and metabolic evaluation. Obes Med. 2019;14(2019):100090. https:\/\/doi.org\/10.1016\/j.obmed.2019.100090.","DOI":"10.1016\/j.obmed.2019.100090"},{"key":"71253","doi-asserted-by":"crossref","unstructured":"25. Milanovi\u0107 M, Milo\u0161evi\u0107 N, Sudji J, et al. Can environmental pollutant bisphenol A increase metabolic risk in polycystic ovary syndrome? Clin Chim Acta. 2020;507:257-63. https:\/\/pubmed.ncbi.nlm.nih.gov\/32387634 https:\/\/doi.org\/10.1016\/j.cca.2020.05.009","DOI":"10.1016\/j.cca.2020.05.009"}],"container-title":["Journal of the ASEAN Federation of Endocrine Societies"],"original-title":[],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T07:40:00Z","timestamp":1745912400000},"score":1,"resource":{"primary":{"URL":"https:\/\/asean-endocrinejournal.org\/index.php\/JAFES\/article\/view\/4905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,27]]},"references-count":25,"URL":"https:\/\/doi.org\/10.15605\/jafes.040.01.14","relation":{},"ISSN":["2308-118X","0857-1074"],"issn-type":[{"value":"2308-118X","type":"electronic"},{"value":"0857-1074","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,27]]}}}