{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T02:49:23Z","timestamp":1763174963608,"version":"3.45.0"},"reference-count":26,"publisher":"Journal of the ASEAN Federation of Endocrine Societies (JAFES)","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J ASEAN Fed Endocr Soc"],"abstract":"<jats:p>Objectives. Gestational diabetes mellitus (GDM), a pregnancy-induced hyperglycemia, affects approximately 17% of pregnancies globally. Its pathophysiology remains unclear, with inflammation and vascular remodeling playing key roles. CD248, a glycoprotein linked to inflammation and vascular remodeling, has been implicated in various conditions, but its role in GDM is uncertain.\nMethodology. A prospective case-control study was conducted with 169 pregnant women aged 18 to 49 at a tertiary hospital. Serum CD248 levels were assessed at 24 to 28 weeks of gestation prior to the oral glucose tolerance test (OGTT). Statistical analyses evaluated the association between CD248 levels, BMI and GDM status.\nResults. Of the participants, 32 (18.9%) were diagnosed with GDM. CD248 levels were lower in GDM patients (8.15 \u00b1 10.16 ng\/mL) than in controls (11.42 \u00b1 15.44 ng\/mL), but the difference was not statistically significant (p = 0.084). Although CD248 levels did not correlate with OGTT values, it was positively associated with BMI (p &lt;0.001).\nConclusion. Unlike earlier findings associating elevated CD248 levels with early pregnancy GDM risk, this study found no significant relationship during later gestational stages. These results highlight a potentially complex and context-dependent role for CD248 in GDM pathophysiology.<\/jats:p>","DOI":"10.15605\/jafes.040.02.13","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T02:45:23Z","timestamp":1763174723000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluating Serum Endosialin (CD248) Levels as a Diagnostic Marker in Gestational Diabetes"],"prefix":"10.15605","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-6777","authenticated-orcid":false,"given":"Tevfik Berk","family":"Bildaci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Ata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2109-1373","authenticated-orcid":false,"given":"Ufuk","family":"Atlihan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin Aytug","family":"AVSAR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcuk","family":"ERKILINC","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6244","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"77857","doi-asserted-by":"crossref","unstructured":"1. 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Associations of glycemia and lipid levels in pregnancy with dyslipidemia 10-14 years later: The HAPO follow-up study. Diabetes Res Clin Pract. 2022;185:109790. https:\/\/pubmed.ncbi.nlm.nih.gov\/35192911 https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9210945 https:\/\/doi.org\/10.1016\/j.diabres.2022.109790","DOI":"10.1016\/j.diabres.2022.109790"},{"key":"77863","doi-asserted-by":"crossref","unstructured":"4. Bardugo A, Bendor CD, Rotem RS, et al. Glucose intolerance in pregnancy and risk of early-onset type 2 diabetes: a population-based cohort study. Lancet Diabetes Endocrinol. 2023;11(5):333-44. https:\/\/pubmed.ncbi.nlm.nih.gov\/37011646 https:\/\/doi.org\/10.1016\/S2213-8587(23)00062-1","DOI":"10.1016\/S2213-8587(23)00062-1"},{"key":"77865","doi-asserted-by":"crossref","unstructured":"5. Pantham P, Aye IL, Powell TL. Inflammation in maternal obesity and gestational diabetes mellitus. 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Arthritis Rheum. 2012;64(10):3334-43. https:\/\/pubmed.ncbi.nlm.nih.gov\/22674221","DOI":"10.1002\/art.34556"},{"key":"77875","doi-asserted-by":"crossref","unstructured":"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4209224 https:\/\/doi.org\/10.1002\/art.34556","DOI":"10.1002\/art.34556"},{"key":"77877","doi-asserted-by":"crossref","unstructured":"10. Teicher BA. CD248: A therapeutic target in cancer and fibrotic diseases. Oncotarget. 2019;10(9):993-1009. https:\/\/pubmed.ncbi.nlm.nih.gov\/30847027","DOI":"10.18632\/oncotarget.26590"},{"key":"77879","doi-asserted-by":"crossref","unstructured":"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6398180 https:\/\/doi.org\/10.18632\/oncotarget.26590","DOI":"10.18632\/oncotarget.26590"},{"key":"77881","doi-asserted-by":"crossref","unstructured":"11. Ohradanova A, Gradin K, Barathova M, et al. Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2. Br J Cancer. 2008;99(8):1348-56. https:\/\/pubmed.ncbi.nlm.nih.gov\/18813310","DOI":"10.1038\/sj.bjc.6604685"},{"key":"77883","doi-asserted-by":"crossref","unstructured":"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2570523 https:\/\/doi.org\/10.1038\/sj.bjc.6604685","DOI":"10.1038\/sj.bjc.6604685"},{"key":"77885","doi-asserted-by":"crossref","unstructured":"12. Hasanov Z, Ruckdeschel T, K\u00f6nig C, et al. Endosialin promotes atherosclerosis through phenotypic remodeling of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2017;37(3):495-505. https:\/\/pubmed.ncbi.nlm.nih.gov\/28126825 https:\/\/doi.org\/10.1161\/ATVBAHA.116.308455","DOI":"10.1161\/ATVBAHA.116.308455"},{"key":"77887","doi-asserted-by":"crossref","unstructured":"13. Mogler C, Wieland M, K\u00f6nig C, et al. Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage. EMBO Mol Med. 2015;7(3):332-8. https:\/\/pubmed.ncbi.nlm.nih.gov\/25680861","DOI":"10.15252\/emmm.201404246"},{"key":"77889","doi-asserted-by":"crossref","unstructured":"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4364949 https:\/\/doi.org\/10.15252\/emmm.201404246","DOI":"10.15252\/emmm.201404246"},{"key":"77891","doi-asserted-by":"crossref","unstructured":"14. Petrus P, Fernandez TL, Kwon MM, et al. Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation. EBioMedicine. 2019;44:489-501. https:\/\/pubmed.ncbi.nlm.nih.gov\/31221584","DOI":"10.1016\/j.ebiom.2019.05.057"},{"key":"77893","doi-asserted-by":"crossref","unstructured":"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6606747 https:\/\/doi.org\/10.1016\/j.ebiom.2019.05.057","DOI":"10.1016\/j.ebiom.2019.05.057"},{"key":"77895","doi-asserted-by":"crossref","unstructured":"15. Wei Y, He A, Huang Z, Liu J, Li R. Placental and plasma early predictive biomarkers for gestational diabetes mellitus. Proteomics Clin Appl. 2022;16(4):e2200001. https:\/\/pubmed.ncbi.nlm.nih.gov\/35385222 https:\/\/doi.org\/10.1002\/prca.202200001","DOI":"10.1002\/prca.202200001"},{"key":"77897","doi-asserted-by":"crossref","unstructured":"16. Benedet PO, Safikhan NS, Pereira MJ, et al. CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation. EBioMedicine. 2024;99:104906. https:\/\/pubmed.ncbi.nlm.nih.gov\/38061240","DOI":"10.1016\/j.ebiom.2023.104906"},{"key":"77899","doi-asserted-by":"crossref","unstructured":"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10750038 https:\/\/doi.org\/10.1016\/j.ebiom.2023.104906","DOI":"10.1016\/j.ebiom.2023.104906"},{"key":"77901","doi-asserted-by":"crossref","unstructured":"17. Zhang Q, Lu C, Lu F, Liao Y, Cai J, Gao J. Challenges and opportunities in obesity: the role of adipocytes during tissue fibrosis. Front Endocrinol (Lausanne). 2024;15:1365156. https:\/\/pubmed.ncbi.nlm.nih.gov\/38686209","DOI":"10.3389\/fendo.2024.1365156"},{"key":"77903","doi-asserted-by":"crossref","unstructured":"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11056552 https:\/\/doi.org\/10.3389\/fendo.2024.1365156","DOI":"10.3389\/fendo.2024.1365156"},{"key":"77905","doi-asserted-by":"crossref","unstructured":"18. Patrick K, Tian X, Cartwright D, et al. Sex-specific effects of CD248 on metabolism and the adipose tissue lipidome. PLoS One. 2023;18(4):e0284012. https:\/\/pubmed.ncbi.nlm.nih.gov\/37115796","DOI":"10.1371\/journal.pone.0284012"},{"key":"77907","doi-asserted-by":"crossref","unstructured":"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10146461 https:\/\/doi.org\/10.1371\/journal.pone.0284012","DOI":"10.1371\/journal.pone.0284012"}],"container-title":["Journal of the ASEAN Federation of Endocrine Societies"],"original-title":[],"link":[{"URL":"https:\/\/asean-endocrinejournal.org\/index.php\/JAFES\/article\/download\/5017\/5277","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/asean-endocrinejournal.org\/index.php\/JAFES\/article\/download\/5017\/5277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T02:45:27Z","timestamp":1763174727000},"score":1,"resource":{"primary":{"URL":"https:\/\/asean-endocrinejournal.org\/index.php\/JAFES\/article\/view\/5017"}},"subtitle":["A Case-Control Study"],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":26,"URL":"https:\/\/doi.org\/10.15605\/jafes.040.02.13","relation":{},"ISSN":["2308-118X","0857-1074"],"issn-type":[{"value":"2308-118X","type":"electronic"},{"value":"0857-1074","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,14]]}}}