{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:13:38Z","timestamp":1777886018747,"version":"3.51.4"},"reference-count":23,"publisher":"Journal of the ASEAN Federation of Endocrine Societies (JAFES)","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J ASEAN Fed Endocr Soc"],"abstract":"<jats:p>Background. Leukocyte telomere length (LTL) is considered a biomarker of cellular senescence. Previous studies have reported the associations between shortened telomere length and type 2 diabetes mellitus (T2DM). However, the role of underlying factors remained unclear. While Ramadan fasting has consistently been shown to improve anthropometric and metabolic parameters in T2DM, its effect on cellular senescence has scarcely been reported.\nObjective. We sought to determine whether Ramadan Fasting affect leukocyte telomere length in persons with T2DM.\nMethodology. An interventional before-and-after study was conducted on 40 to 60-year-old subjects with T2DM consecutively recruited before Ramadan fasting (May 2018 and May 2019) from the Internal Medicine Outpatient Clinic at Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. Relative LTL was compared between 48 subjects before Ramadan fasting and after at least 14 days of fasting and then adjusted with key clinical and biochemical parameters.\nResults. The relative rLTL in subjects with T2DM was comparable between before and after at least 14 days of Ramadan fasting. (0.391 [0.021\u20131.515] vs 1.117 [0.528\u20131.741], p = 0.112).\nConclusion. No significant difference was found in relative leukocyte telomere length among subjects with type 2 diabetes who have undergone Ramadan fasting for at least 14 days. However, this study showed a tendency to have an increase in relative LTL.<\/jats:p>","DOI":"10.15605\/jafes.041.01.5071","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:21:34Z","timestamp":1777605694000},"source":"Crossref","is-referenced-by-count":0,"title":["The Association of Ramadan Fasting on Relative Leukocyte Telomere Length in Type 2 Diabetes Mellitusc"],"prefix":"10.15605","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3277-5225","authenticated-orcid":false,"given":"Mona","family":"Hardika","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0265-9883","authenticated-orcid":false,"given":"Farid","family":"Kurniawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5889-7581","authenticated-orcid":false,"given":"Purwita Wijaya","family":"Laksmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syahidatul","family":"Wafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0700-5195","authenticated-orcid":false,"given":"Rheza Meida","family":"Marliau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agian Jeffilano","family":"Barinda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dante","family":"Harbuwono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4048-5159","authenticated-orcid":false,"given":"Dicky","family":"Tahapary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6244","published-online":{"date-parts":[[2026,4,26]]},"reference":[{"key":"84813","unstructured":"International Diabetes Federation. 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Diabetes. 2015;64(7):2289\u201398. https:\/\/pubmed.ncbi.nlm.nih.gov\/26106186 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4477358 https:\/\/doi.org\/10.2337\/db14-1820","DOI":"10.2337\/db14-1820"},{"key":"84818","doi-asserted-by":"crossref","unstructured":"Jeanclos E, Krolewski A, Skurnick J, Kimura M, Aviv H, Warram JH, et al. Shortened telomere length in white blood cells of patients with IDDM. Diabetes. 1998;47(3):482\u20136. https:\/\/pubmed.ncbi.nlm.nih.gov\/9519758 https:\/\/doi.org\/10.2337\/diabetes.47.3.482","DOI":"10.2337\/diabetes.47.3.482"},{"key":"84819","doi-asserted-by":"crossref","unstructured":"Zhao J, Miao K, Wang H, Ding H, Wang DW. Association between telomere length and type 2 diabetes mellitus: A meta-analysis. PLoS One. 2013;8(11):e79993. https:\/\/pubmed.ncbi.nlm.nih.gov\/24278229 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3836967 https:\/\/doi.org\/10.1371\/journal.pone.0079993","DOI":"10.1371\/journal.pone.0079993"},{"key":"84820","doi-asserted-by":"crossref","unstructured":"Cheng F, Luk AO, Tam CHT, et al. Shortened relative leukocyte telomere length is associated with prevalent and incident cardiovascular complications in type 2 diabetes: Analysis from the Hong Kong Diabetes Register. Diabetes Care. 2020;43(9):2257\u201365. https:\/\/pubmed.ncbi.nlm.nih.gov\/32661111 https:\/\/doi.org\/10.2337\/dc20-0028","DOI":"10.2337\/dc20-0028"},{"key":"84821","doi-asserted-by":"crossref","unstructured":"Burton DGA, Faragher RGA. Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing. 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