{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:06:53Z","timestamp":1777630013126,"version":"3.51.4"},"reference-count":20,"publisher":"Journal of the ASEAN Federation of Endocrine Societies (JAFES)","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J ASEAN Fed Endocr Soc"],"abstract":"<jats:p>Persistent hypoaldosteronism post-adrenalectomy for unilateral primary aldosteronism is not uncommon and should be anticipated in patients with risk factors for development of such condition. Most cases of hypoaldosteronism post-adrenalectomy are transient. However, persistent hypoaldosteronism may occur as a result of delayed recovery of contralateral zona glomerulosa suppression, requiring mineralocorticoid replacement for the prevention or treatment of life-threatening hyperkalemia.<\/jats:p>","DOI":"10.15605\/jafes.041.01.5151","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:45:45Z","timestamp":1777430745000},"source":"Crossref","is-referenced-by-count":0,"title":["The Lingering Battle of Persistent Hypoaldosteronism Following Adrenalectomy for Primary Aldosteronism:"],"prefix":"10.15605","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2290-0987","authenticated-orcid":false,"given":"Jie En","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nor Shaffinaz","family":"Yusoff Azmi Merican","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shartiyah","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor Rafhati Adyani","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6244","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"84778","doi-asserted-by":"crossref","unstructured":"Insufficiency causing hyperkalemia in primary aldosteronism after adrenalectomy. J Clin Endocrinol Metab. 2012;97(11):3965-73. https:\/\/pubmed.ncbi.nlm.nih.gov\/22893716 https:\/\/doi.org\/10.1210\/jc.2012-2234","DOI":"10.1210\/jc.2012-2234"},{"key":"84779","doi-asserted-by":"crossref","unstructured":"Park KS, Kim JH, Ku EJ, et al. Clinical risk factors of postoperative hyperkalemia after adrenalectomy in patients with aldosterone-producing adenoma. Eur J Endocrinol. 2015;172(6):725-31. https:\/\/pubmed.ncbi.nlm.nih.gov\/25766046 https:\/\/doi.org\/10.1530\/EJE-15-0074","DOI":"10.1530\/EJE-15-0074"},{"key":"84780","doi-asserted-by":"crossref","unstructured":"Chiang WF, Cheng CJ, Wu ST, et al. Incidence and factors of post-adrenalectomy hyperkalemia in patients with aldosterone producing adenoma. Clin Chim Acta. 2013;424:114-8. https:\/\/pubmed.ncbi.nlm.nih.gov\/23727469 https:\/\/doi.org\/10.1016\/j.cca.2013.05.017","DOI":"10.1016\/j.cca.2013.05.017"},{"key":"84781","doi-asserted-by":"crossref","unstructured":"Funder JW, Carey RM, Mantero F, et al. The management of primary aldosteronism: Case detection, diagnosis, and treatment: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2016;101(5):1889-916. https:\/\/pubmed.ncbi.nlm.nih.gov\/2693439 https:\/\/doi.org\/10.1210\/jc.2015-4061","DOI":"10.1210\/jc.2015-4061"},{"key":"84782","doi-asserted-by":"crossref","unstructured":"Biglieri EG, Slaton PE Jr, Silen WS, Galante M, Forsham PH. Postoperative studies of adrenal function in primary aldosteronism. J Clin Endocrinol Metab. 1966;26(5):553-8. https:\/\/pubmed.ncbi.nlm.nih.gov\/4287160 https:\/\/doi.org\/10.1210\/jcem-26-5-553","DOI":"10.1210\/jcem-26-5-553"},{"key":"84783","doi-asserted-by":"crossref","unstructured":"Mermejo LM, Elias PCL, Molina CAF, et al. Early renin recovery after adrenalectomy in aldosterone-producing adenomas: A prospective study. Horm Metab Res. 2022;54(4):224-31. https:\/\/pubmed.ncbi.nlm.nih.gov\/35413743 https:\/\/doi.org\/10.1055\/a-1778-4002","DOI":"10.1055\/a-1778-4002"},{"key":"84784","unstructured":"Hajmomenian HR. Hyperkalemia following unilateral adrenalectomy for adrenal adenoma. Proc UCLA Health. 2013;17. https:\/\/escholarship.org\/uc\/item\/2n7208zw"},{"key":"84785","unstructured":"Mustaqeem R, Arif A. Renal tubular acidosis. StatPearls. Treasure Island (FL): StatPearls Publishing; 2026."},{"key":"84786","doi-asserted-by":"crossref","unstructured":"Hyland K, Perkins J. Persistent hyperkalemia status post-adrenalectomy for primary aldosteronism. Endocr Pract. https:\/\/doi.org\/10.4158\/EP15812.CR","DOI":"10.4158\/EP15812.CR"},{"key":"84787","doi-asserted-by":"crossref","unstructured":"Angus LM, Yang J, Cheung AS. Persistent hypoaldosteronism post-adrenalectomy for primary aldosteronism: A role for pre-operative spironolactone? Endocrinol Diabetes Metab Case Rep. 2021;2021:21-0137. https:\/\/pubmed.ncbi.nlm.nih.gov\/34695011","DOI":"10.1530\/EDM-21-0137"},{"key":"84788","doi-asserted-by":"crossref","unstructured":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8558879 https:\/\/doi.org\/10.1530\/EDM-21-0137","DOI":"10.1530\/EDM-21-0137"},{"key":"84789","doi-asserted-by":"crossref","unstructured":"Wada N, Baba S, Sugawara H, et al. Prolonged postoperative hypoaldosteronism related to hyperkalemia in patients with aldosterone-producing adenoma. Endocr J. 2023;70(9):917-24. https:\/\/pubmed.ncbi.nlm.nih.gov\/37423737 https:\/\/doi.org\/10.1507\/endocrj.EJ23-0174","DOI":"10.1507\/endocrj.EJ23-0174"},{"key":"84790","doi-asserted-by":"crossref","unstructured":"Tahir A, McLaughlin K, Kline G. Severe hyperkalemia following adrenalectomy for aldosteronoma: Prediction, pathogenesis and approach to clinical management: A case series. BMC Endocr Disord. 2016;16(1):43. https:\/\/pubmed.ncbi.nlm.nih.gov\/27460219","DOI":"10.1186\/s12902-016-0121-y"},{"key":"84791","doi-asserted-by":"crossref","unstructured":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4962422 https:\/\/doi.org\/10.1186\/s12902-016-0121-y Rossi GP, Bernini G, Desideri G, et al. Renal damage in primary aldosteronism: Results of the PAPY Study. Hypertension. 2006;48(2):232-8. https:\/\/pubmed.ncbi.nlm.nih.gov\/16801482 https:\/\/doi.org\/10.1161\/01.HYP.0000230444.01215.6a","DOI":"10.1161\/01.HYP.0000230444.01215.6a"},{"key":"84792","doi-asserted-by":"crossref","unstructured":".Shariq OA, Bancos I, Cronin PA, et al. Contralateral suppression of aldosterone at adrenal venous sampling predicts hyperkalemia following adrenalectomy for primary aldosteronism. Surgery. 2018;163(1):183-90. https:\/\/pubmed.ncbi.nlm.nih.gov\/29129366 https:\/\/doi.org\/10.1016\/j.surg.2017.07.034","DOI":"10.1016\/j.surg.2017.07.034"},{"key":"84793","doi-asserted-by":"crossref","unstructured":".Mai X, Kometani M, Yoneda T. Spontaneous remission of primary aldosteronism with mineralocorticoid receptor antagonist therapy: A review. Int J Mol Sci. 2022;23(22):13821. https:\/\/pubmed.ncbi.nlm.nih.gov\/36430298 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9698409 https:\/\/doi.org\/10.3390\/ijms232213821","DOI":"10.3390\/ijms232213821"},{"key":"84794","doi-asserted-by":"crossref","unstructured":"Gadallah MF, Kayyas Y, Boules F. Reversible suppression of the renin-aldosterone axis after unilateral adrenalectomy for adrenal adenoma. Am J Kidney Dis. 1998;32(1):160-3. https:\/\/pubmed.ncbi.nlm.nih.gov\/9669438 https:\/\/doi.org\/10.1053\/ajkd.1998.v32.pm9669438","DOI":"10.1053\/ajkd.1998.v32.pm9669438"},{"key":"84795","doi-asserted-by":"crossref","unstructured":"Starker LF, Christakis I, St Julien J, et al. Considering postoperative functional hypoaldosteronism after unilateral adrenalectomy. Am Surg. 2017;83(6):598-604. https:\/\/pubmed.ncbi.nlm.nih.gov\/28637561","DOI":"10.1177\/000313481708300624"},{"key":"84796","doi-asserted-by":"crossref","unstructured":"Yorke E, Stafford S, Holmes D, et al. Aldosterone deficiency after unilateral adrenalectomy for Conn's syndrome: A case report and literature review. Int J Surg Case Rep. 2015;7C:141-4. https:\/\/pubmed.ncbi.nlm.nih.gov\/25604311 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4336421 https:\/\/doi.org\/10.1016\/j.ijscr.2015.01.013","DOI":"10.1016\/j.ijscr.2015.01.013"},{"key":"84797","doi-asserted-by":"crossref","unstructured":"Taniguchi R, Koshiyama H, Yamauchi M, et al. A case of aldosterone-producing adenoma with severe postoperative hyperkalemia. Tohoku J Exp Med. 1998;186(3):215-23. https:\/\/pubmed.ncbi.nlm.nih.gov\/10348217 https:\/\/doi.org\/10.1620\/tjem.186.215","DOI":"10.1620\/tjem.186.215"}],"container-title":["Journal of the ASEAN Federation of Endocrine Societies"],"original-title":[],"link":[{"URL":"https:\/\/asean-endocrinejournal.org\/index.php\/JAFES\/article\/download\/5151\/5329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/asean-endocrinejournal.org\/index.php\/JAFES\/article\/download\/5151\/5329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:46:05Z","timestamp":1777430765000},"score":1,"resource":{"primary":{"URL":"https:\/\/asean-endocrinejournal.org\/index.php\/JAFES\/article\/view\/5151"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":20,"URL":"https:\/\/doi.org\/10.15605\/jafes.041.01.5151","relation":{},"ISSN":["2308-118X","0857-1074"],"issn-type":[{"value":"2308-118X","type":"electronic"},{"value":"0857-1074","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,27]]}}}