{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:36:54Z","timestamp":1777106214851,"version":"3.51.4"},"reference-count":30,"publisher":"Journal of the ASEAN Federation of Endocrine Societies (JAFES)","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J ASEAN Fed Endocr Soc"],"abstract":"<jats:p>Objective. To explore the impact of chronic kidney disease (CKD) on hospitalized patients with diabetic foot ulcers (DFU) at a tertiary diabetes center in Thailand.\nMethodology. A retrospective study reviewed hospitalized DFU admissions at Vimut-Theptarin Hospital from 2019 to 2023. Ulcer-related outcomes included complete wound healing at 12 months, major and minor amputations, and 1-year mortality.\nResults. A total of 265 DFU admissions from 225 patients were included (male 60.4%; age 66.7 \u00b1 13.4 years; A1C 8.2 \u00b1 2.3%; advanced CKD 26.1%; peripheral arterial disease 54.7%). Severe DFU (Wagner grade \u22653) comprised 60.0% of all DFUs, and almost one-third of patients had prior amputations. Complete healing occurred in 69.8%; major amputation in 4.9%; minor amputation in 30.9%; and the 1-year mortality rate after discharge was 11.7%. Advanced CKD (stages 4\u20135) increased the odds of non-healed ulcers (odds ratio [OR] 2.69; 95% confidence interval [CI] 1.46\u20134.98; P = 0.002) and 1-year mortality (21.7% vs 8.4%; P = 0.004).\nConclusion. Advanced chronic kidney disease (CKD) is associated with poorer ulcer-related outcomes in hospitalized patients with diabetic foot ulcers (DFU). Proactive foot care and early referral to multidisciplinary teams, particularly for dialysis-dependent patients, remain essential. Despite ongoing advances in DFU management, these patients continue to face higher rates of non-healing ulcers and mortality, underscoring the need for coordinated inter-institutional care and enhanced public education efforts.<\/jats:p>","DOI":"10.15605\/jafes.041.01.5197","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:49:26Z","timestamp":1777103366000},"source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Chronic Kidney Disease on Ulcer-Related Outcomes in Hospitalized Diabetic Foot Ulcers"],"prefix":"10.15605","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8853-0782","authenticated-orcid":false,"given":"Jeeraphan","family":"Sripatpong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirinate","family":"Krittiyawong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0880-6693","authenticated-orcid":false,"given":"Waralee","family":"Chatchomchuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekgaluck","family":"Wanothayaroj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taweesak","family":"Srikummoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poovasit","family":"Klinoubol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4714-790X","authenticated-orcid":false,"given":"Phawinpon","family":"Chotwanvirat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriwan","family":"Butadej","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5032-8296","authenticated-orcid":false,"given":"Soontaree","family":"Nakasatien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thep","family":"Himathongkam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2317-4041","authenticated-orcid":false,"given":"Yotsapon","family":"Thewjitcharoen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6244","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"key":"84303","doi-asserted-by":"crossref","unstructured":"Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376(24):2367-75. https:\/\/pubmed.ncbi.nlm.nih.gov\/28614678 DOI: 10.1056\/NEJMra1615439","DOI":"10.1056\/NEJMra1615439"},{"key":"84304","doi-asserted-by":"crossref","unstructured":"Hoffstad O, Mitra N, Walsh J et al. Diabetes, lower-extremity amputation, and death. Diabetes Care. 2015;38(10):1852-7. https:\/\/pubmed.ncbi.nlm.nih.gov\/26203063 DOI: 10.2337\/dc15-0536","DOI":"10.2337\/dc15-0536"},{"key":"84305","doi-asserted-by":"crossref","unstructured":"Morbach S, Furchert H, Gr\u00f6blinghoff U et al. Long-term prognosis of diabetic foot patients and their limbs: Amputation and death over the course of a decade. Diabetes Care. 2012;35(10):2021-7. https:\/\/pubmed.ncbi.nlm.nih.gov\/22815299 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3447849 https:\/\/doi.org\/10.2337\/dc12-0200","DOI":"10.2337\/dc12-0200"},{"key":"84306","doi-asserted-by":"crossref","unstructured":"Wolf G, M\u00fcller N, Busch M et al. Diabetic foot syndrome and renal function in type 1 and 2 diabetes mellitus show close association. Nephrol Dial Transplant. 2009;24(6):1896-901. https:\/\/pubmed.ncbi.nlm.nih.gov\/19131351 https:\/\/doi.org\/10.1093\/ndt\/gfn724","DOI":"10.1093\/ndt\/gfn724"},{"key":"84307","doi-asserted-by":"crossref","unstructured":"Otte J, van Netten JJ, Woittiez AJJ. The association of chronic kidney disease and dialysis treatment with foot ulceration and major amputation. J Vasc Surg. 2015;62(2):406-11. https:\/\/pubmed.ncbi.nlm.nih.gov\/25937604 https:\/\/doi.org\/10.1016\/j.jvs.2015.02.051","DOI":"10.1016\/j.jvs.2015.02.051"},{"key":"84308","doi-asserted-by":"crossref","unstructured":"Bonnet JB, Sultan A. Narrative review of the relationship between CKD and diabetic foot ulcer. Kidney Int Rep. 2021;7(3):381-8. https:\/\/pubmed.ncbi.nlm.nih.gov\/35257052 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8897302 https:\/\/doi.org\/10.1016\/j.ekir.2021.12.018","DOI":"10.1016\/j.ekir.2021.12.018"},{"key":"84309","doi-asserted-by":"crossref","unstructured":"Salim M. Clinical outcomes among patients with chronic kidney disease hospitalized with diabetic foot disorders: A nationwide retrospective study. Endocrinol Diabetes Metab. 2021;4(3):e00277. https:\/\/pubmed.ncbi.nlm.nih.gov\/34277993 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8279616 https:\/\/doi.org\/10.1002\/edm2.277","DOI":"10.1002\/edm2.277"},{"key":"84310","doi-asserted-by":"crossref","unstructured":"Gershater MA, L\u00f6ndahl M, Nyberg P et al. Complexity of factors related to outcome of neuropathic and neuroischaemic\/ischaemic diabetic foot ulcers: A cohort study. 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