{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:21:47Z","timestamp":1787905307643,"version":"build-2784847793"},"reference-count":37,"publisher":"Journal of the ASEAN Federation of Endocrine Societies (JAFES)","issue":"2","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J ASEAN Fed Endocr Soc"],"abstract":"<jats:p>Objective. To evaluate the quality of life (QoL) of patients with pituitary adenoma following Endoscopic Endonasal Transsphenoidal Surgery (EETS) and identify factors influencing long-term outcomes.\nMethodology. A cross-sectional study was conducted at the National Brain Center Hospital, Indonesia. Secondary data were obtained from medical records and the pituitary registry, while primary data were collected through patient interviews using the validated Indonesian version of the SF-36 questionnaire. Statistical analyses included univariate, bivariate, and multivariate linear regression with the backward method to identify independent predictors of QoL.\nResults. Among 90 patients (45 males, 45 females), visual disturbances (85.6%) and hormonal deficiencies (93.3%) were common. Most had macroadenomas (95.6%) and received combined EETS and medical therapy (62.2%). Physical component scores (PCS) exceeded mental component scores (MCS). The highest domain scores were in physical functioning and role-emotional functioning; vitality and mental health had the lowest scores. Gender was significantly associated with four QoL domains, and hormonal deficiency affected the role-emotional domain. Multivariate analysis identified gender and hormonal deficiency as predictors of MCS (R\u00b2 = 74%); no factors significantly influenced PCS.\nConclusion. Postoperative QoL after EETS is generally good in physical aspects but suboptimal in mental health. Gender and hormonal deficiency affect mental QoL, highlighting the need for holistic, long-term care strategies.<\/jats:p>","DOI":"10.15605\/jafes.041.02.6141","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:15:23Z","timestamp":1787904923000},"source":"Crossref","is-referenced-by-count":0,"title":["Factors Affecting Long-Term Outcomes and Quality of Life of Patients with Pituitary Adenoma After Endoscopic Endonasal Transsphenoidal Surgery (EETS) Using the SF-36 Questionnaire (Indonesian Version)"],"prefix":"10.15605","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1189-4886","authenticated-orcid":false,"given":"Novie Rahmawati","family":"Zirta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Tri Juli Edi Tarigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Rudi Putranto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Murdani Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Budiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Arya Govinda Roosheroe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Edy Rizal Wahyudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6244","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"87217","doi-asserted-by":"crossref","unstructured":"1. 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Laryngoscope Investig Otolaryngol. 2023;8(1):7-15. https:\/\/pubmed.ncbi.nlm.nih.gov\/36846430 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9948581 https:\/\/doi.org\/10.1002\/lio2.1004","DOI":"10.1002\/lio2.1004"},{"key":"87232","unstructured":"16. Salim S, Yamin M, Alwi I, Setiati S. Validity and reliability of the Indonesian version of SF-36 quality of life questionnaire on patients with permanent pacemakers. Acta Med Indones. 2017;49(1):10-6. https:\/\/pubmed.ncbi.nlm.nih.gov\/28450649"},{"key":"87233","doi-asserted-by":"crossref","unstructured":"17. Arovah NI, Heesch KC. Verification of the reliability and validity of the Short Form-36 scale in Indonesian middle-aged and older adults. 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Endocr Pathol. 2022;33(1):6-26. https:\/\/pubmed.ncbi.nlm.nih.gov\/35291028 https:\/\/doi.org\/10.1007\/s12022-022-09703-7","DOI":"10.1007\/s12022-022-09703-7"},{"key":"87236","doi-asserted-by":"crossref","unstructured":"20. Melmed S, Kaiser UB, Lopes MB, , et al. Clinical biology of the pituitary adenoma. Endocr Rev. 2022;43(6):1003-37. https:\/\/pubmed.ncbi.nlm.nih.gov\/35395078 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9695123 https:\/\/doi.org\/10.1210\/endrev\/bnac010","DOI":"10.1210\/endrev\/bnac010"},{"key":"87237","unstructured":"21. Perkumpulan Endokrinologi Indonesia. Konsensus Pendekatan Diagnosis Adenoma Hipofisis. Jakarta, Indonesia: Perkumpulan Endokrinologi Indonesia; 2024. https:\/\/pbperkeni.or.id\/uncategorized\/konsensus-pendekatan-diagnosis-adenoma-hipofisis_final-revision-1-okt-2024-1"},{"key":"87238","doi-asserted-by":"crossref","unstructured":"22. Vega-Beyhart A, Enriquez-Estrada VM, Bello-Chavolla OY, et al. 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Acta Neurochir (Wien). 2012;154(10):1895\u20131902. https:\/\/doi.org\/10.1007\/s00701-012-1473-3","DOI":"10.1007\/s00701-012-1473-3"}],"container-title":["Journal of the ASEAN Federation of Endocrine Societies"],"original-title":[],"link":[{"URL":"https:\/\/asean-endocrinejournal.org\/index.php\/JAFES\/article\/download\/6141\/5358","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/asean-endocrinejournal.org\/index.php\/JAFES\/article\/download\/6141\/5358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:15:33Z","timestamp":1787904933000},"score":1,"resource":{"primary":{"URL":"https:\/\/asean-endocrinejournal.org\/index.php\/JAFES\/article\/view\/6141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,8,6]]}},"URL":"https:\/\/doi.org\/10.15605\/jafes.041.02.6141","relation":{},"ISSN":["2308-118X","0857-1074"],"issn-type":[{"value":"2308-118X","type":"electronic"},{"value":"0857-1074","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}