{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T05:41:38Z","timestamp":1772343698510,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T00:00:00Z","timestamp":1177891200000},"content-version":"vor","delay-in-days":425,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Repetitive exposure of the skin to UV radiation induces various harmful changes, such as thickening, wrinkle formation, inflammation and carcinogenesis. A variety of natural compounds and synthetic compounds have been studied to determine whether they can prevent W\u2010induced harmful effects. In this study, we investigated the effect of a novel compound, Melanocin A, which was isolated from <jats:italic>Eupenicillium shearii<\/jats:italic> F80695, on UV\u2010induced premature skin aging. First, we studied the effect of Melanocin A on UV\u2010induced matrix metalloproteinase (MMP)\u20109 expression in an immortalized human keratinocyte cell line, HaCaT, <jats:italic>in vitro<\/jats:italic>. Acute UV irradiation induced MMP\u20109 expression at both the mRNA and protein levels and Melanocin A suppressed this expression in a dose\u2010dependent manner. We then investigated the effect of Melanocin A on UV\u2010induced skin changes in hairless mice <jats:italic>in vivo<\/jats:italic>. Chronic exposure of hairless mouse dorsal skin to UV increased skin thickness and induced wrinkle formation and the gelatinase activities of MMP\u20102 and MMP\u20109. Moreover, Melanocin A significantly suppressed UV\u2010induced morphologic skin changes and MMP\u20102 and MMP\u20109 expression. Taken together, these results show that Melanocin A can prevent the harmful effects of UV that lead to skin aging. Therefore, we suggest that Melanocin A should be viewed as a potential therapeutic agent for preventing and\/or treating premature skin aging.<\/jats:p>","DOI":"10.1562\/2005-07-26-ra-623","type":"journal-article","created":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T19:26:11Z","timestamp":1133292371000},"page":"574-578","source":"Crossref","is-referenced-by-count":32,"title":["Prevention of UV Radiation\u2010Induced Premature Skin Aging in Hairless Mice by the Novel Compound Melanocin A"],"prefix":"10.1111","volume":"82","author":[{"given":"Chi\u2010Hyun","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Pyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ick Dong","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Ho","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(99)00076-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-1637(02)00024-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1001\/jama.1969.03160390039008","article-title":"Early destructive effect of sunlight on human skin","volume":"210","author":"Kligrnan A. 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