{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:11:18Z","timestamp":1789495878007,"version":"build-2803163510"},"reference-count":75,"publisher":"American Academy of Implant Dentistry","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>The goal of this retrospective study was to evaluate the survival rates of dental implants placed in sinuses grafted with a 50:50 composite ratio of autogenous bone and a natural flourohydroxyapatite (FHA) combined with platelet-rich plasma (PRP) using an immediate-load protocol. The authors hypothesized that a 50:50 composite ratio of FHA and autogenous bone combined with PRP would permit immediate loading without compromising implant survival rates. Eleven patients with bilateral partial edentulism of the posterior maxilla were enrolled in this retrospective study. Autogenous bone used in the graft procedure was harvested from the tibia of the left lower extremity. Each patient was grafted with a 50:50 composite ratio of autogenous bone and FHA. Membranes were not used to cover the lateral wall osteotomy site. Platelet-rich plasma was added to the graft material to accelerate and enhance bone regeneration. Four to 6 months after the grafting procedure, 37 hydroxyapatite-coated dental implants were surgically placed and immediately loaded between 72 hours and 5 days later with custom titanium abutments and acrylic provisional restorations placed out of functional occlusion. Six months later, definitive ceramometal restorations were cemented on to the custom abutments. Patients were observed over a 52-week period. The overall implant survival rate was 97.3%. Histologic and histomorphometric analysis of core samples revealed formation of new vital bone in different graft specimens ranging from 23% to 34%. In each core bone sample, 100% of the bone sample was determined to be vital. In the grafted maxillary sinus, the natural FHA combined with autogenous bone in a 50:50 composite ratio with PRP is a suitable graft material permitting immediate load without compromising implant survival rates while decreasing the overall healing time.<\/jats:p>","DOI":"10.1563\/1548-1336-35.4.164","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T11:16:04Z","timestamp":1252062964000},"page":"164-175","source":"Crossref","is-referenced-by-count":14,"title":["Sinus Grafting With a Natural Flourohydroxyapatite for Immediate Load: A Study With Histologic Analysis and Histomorphometry"],"prefix":"10.1563","volume":"35","author":[{"given":"Cameron Y. S.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari S.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Stover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon B.","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"434","reference":[{"key":"i1548-1336-35-4-164-b01","series-title":"J Oral Surg.","first-page":"613","article-title":"Grafting of the maxillary sinus floor with autogenous marrow and bone.","volume":"38","author":"Boyne, P. J.","year":"1980","unstructured":"Boyne, P. J. and R. A.James. 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Effect of maxillary sinus augmentation on the survival of endosseous implants: a systematic review.Ann Periodontol.2003. 8:328\u2013343."},{"key":"i1548-1336-35-4-164-b14","series-title":"Int J Periodontics Restor Dent.","first-page":"565","article-title":"Systematic review of survival rates for implants placed in the grafted maxillary sinus.","volume":"24","author":"Del Fabbro, M.","year":"2004","unstructured":"Del Fabbro, M., T.Testori, and L.Francetti. et al. Systematic review of survival rates for implants placed in the grafted maxillary sinus.Int J Periodontics Restor Dent.2004. 24:565\u2013578."},{"key":"i1548-1336-35-4-164-b15","series-title":"Maxillary Sinus Augmentation.","author":"Wallace, S. S.","year":"2005","unstructured":"Wallace, S. 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Augmentation of the maxillary sinus floor with particulated mandible: a histologic and histomorphometric study.Int J Oral Maxillofac Implants.1996. 11:760\u2013769."},{"key":"i1548-1336-35-4-164-b21","series-title":"Int J Oral Maxillofac Implants.","first-page":"69","article-title":"Bone augmentation of the inferior floor of the maxillary sinus with autogenous bone or composite bone grafts: a histologic- histomorphometric preliminary report.","volume":"13","author":"Lorenzetti, M.","year":"1998","unstructured":"Lorenzetti, M., M.Mozzatti, and P. P.Campanino. et al. Bone augmentation of the inferior floor of the maxillary sinus with autogenous bone or composite bone grafts: a histologic- histomorphometric preliminary report.Int J Oral Maxillofac Implants.1998. 13:69\u201376."},{"key":"i1548-1336-35-4-164-b22","series-title":"Int J Oral Maxillofac Implants.","first-page":"233","article-title":"Maxillary sinus grafting with anorganic bovine bone: a clinical report of long term results.","volume":"17","author":"Valenti, P.","year":"1997","unstructured":"Valenti, P. and D. J.Abensur. Maxillary sinus grafting with anorganic bovine bone: a clinical report of long term results.Int J Oral Maxillofac Implants.1997. 17:233\u2013241."},{"key":"i1548-1336-35-4-164-b23","series-title":"Int J Periodontics Restor Dent.","first-page":"529","article-title":"Sinus floor elevation using anorganic bovine bone matrix (Osteograf\/N) with and without autogenous bone: a clinical, histologic, radiographic and histomorphometric analysis.","volume":"18","author":"Froum, S. J.","year":"1998","unstructured":"Froum, S. J., D. P.Tarnow, and S. S.Wallace. Sinus floor elevation using anorganic bovine bone matrix (Osteograf\/N) with and without autogenous bone: a clinical, histologic, radiographic and histomorphometric analysis.Int J Periodontics Restor Dent.1998. 18:529\u2013543."},{"key":"i1548-1336-35-4-164-b24","series-title":"Compend.","first-page":"259","article-title":"The use of mineralized allograft for sinus augmentation: an interim histological case report from a prospective clinical study.","volume":"26","author":"Froum, S. J.","year":"2005","unstructured":"Froum, S. J., D. P.Tarnow, and S. S.Wallace. et al. 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Mesenchymal stem cells: clinical applications and biological characterization.Int J Biochem Cell Biol.2004. 36:568\u2013584."},{"key":"i1548-1336-35-4-164-b44","series-title":"J Oral Maxillofac Surg.","first-page":"443","article-title":"Effects of platelet-rich plasma on the healing of autogenous bone grafted mandibular defects in dogs.","volume":"64","author":"Gerard, D.","year":"2006","unstructured":"Gerard, D., E. R.Carlson, and J. E.Gotcher. et al. Effects of platelet-rich plasma on the healing of autogenous bone grafted mandibular defects in dogs.J Oral Maxillofac Surg.2006. 64:443\u2013451."},{"key":"i1548-1336-35-4-164-b45","series-title":"Int J Oral Maxillofac Implants.","first-page":"535","article-title":"Immunohistochemical analysis of cortical and cancellous bone after radiation and the effect of platelet-rich plasma on autogenous bone grafting.","volume":"21","author":"Aghaloo, T. L.","year":"2006","unstructured":"Aghaloo, T. L., A. D.Le, and E. G.Freymiller. et al. 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Use of particulate dentin-Plaster of Paris combination with\/without platelet rich plasma in the treatment of bone defects around implants.Int J Oral Maxillofac Implants.2002. 17:86\u201394."},{"key":"i1548-1336-35-4-164-b49","series-title":"Int J Oral Maxillofac Surg.","first-page":"56","article-title":"Effect of platelet-rich plasma on bone regeneration in autogenous bone graft.","volume":"33","author":"Choi, B. K.","year":"2004","unstructured":"Choi, B. K., C. J.Im, and J. Y.Huh. et al. Effect of platelet-rich plasma on bone regeneration in autogenous bone graft.Int J Oral Maxillofac Surg.2004. 33:56\u201359."},{"key":"i1548-1336-35-4-164-b50","series-title":"J Orthop Res.","first-page":"653","article-title":"Platelet rich plasma and fresh frozen bone allograft as enhancement of implant fixation: an experimental study in dogs.","volume":"22","author":"Jensen, T. B.","year":"2004","unstructured":"Jensen, T. B., O.Rahbek, and S.Overgaard. et al. 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