{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:47:07Z","timestamp":1787669227816,"version":"build-2736575974"},"reference-count":27,"publisher":"American Academy of Implant Dentistry","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>No well-established evidence supporting safe use of bisphosphonates (BPs) or other antiresorptive agents prior, during, or after dentoalveolar surgery, are currently available; moreover, the real risk of osteonecrosis of the jaw (ONJ) development is still unknown. The aim of the present systematic review was to assess the scientific literature concerning the implants placement in antiresorptive agent users and the related risk of implants failure and ONJ development. English papers published from January 2003 until December 2014 were identified on the MEDLINE database. Titles and abstracts retrieved form electronic search were screened separately by 2 examiners; thus, original studies dealing with dental implants placement during or before bone antiresorptive agent therapy and the relative risk of implant failure or development of osteonecrosis were evaluated. Due to the heterogeneity of the included studies and the high risk of bias, there is no evidence of the safe use of oral antiresorptive agents prior or after dental implant surgery. Indeed, implant failure and ONJ development can occur and represent a devastating side effect that should be considered during treatment. Within the limitation of the present systematic review, high quality studies are needed to provide an adequate level of evidence regarding the safety of dentoalveolar surgery during or before bone resorption inhibition therapy and the increase predisposition to osteonecrosis of the jaw (ONJ) development. Therefore, antiresorptive agent therapy should be considered a risk factor until further evidence is prospectively obtained.<\/jats:p>","DOI":"10.1563\/aaid-joi-16-00057","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T15:04:37Z","timestamp":1487862277000},"page":"51-57","source":"Crossref","is-referenced-by-count":31,"title":["Medication-Related Osteonecrosis of the Jaw and Dental Implants Failures: A Systematic Review"],"prefix":"10.1563","volume":"43","author":[{"given":"Riccardo","family":"Guazzo","sequence":"first","affiliation":[{"name":"Department of Neurosciences, University of Padova, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Sbricoli","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of Padova, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of Padova, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriberto","family":"Bressan","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of Padova, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Piattelli","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences, University \u201cG. d'Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Iaculli","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences, University \u201cG. d'Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"434","reference":[{"key":"i1548-1336-43-1-51-Marx1","series-title":"J Oral Maxillofac Surg","first-page":"1115","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx \n              RE.","year":"2003","unstructured":"Marx \n              RE. \n            \n          \n          Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003;61:1115\u20131117."},{"key":"i1548-1336-43-1-51-Vescovi1","series-title":"Clin Cases Miner Bone Metab","first-page":"142","article-title":"Bisphosphonates and osteonecrosis: an open matter","volume":"9","author":"Vescovi \n              P.","year":"2012","unstructured":"Vescovi \n              P. \n            \n          \n          Bisphosphonates and osteonecrosis: an open matter. Clin Cases Miner Bone Metab. 2012;9:142\u2013144."},{"key":"i1548-1336-43-1-51-Vescovi2","series-title":"J Oral Pathol Med","first-page":"214","article-title":"Bisphosphonates-related osteonecrosis of the jaws: a concise review of the literature and a report of a single-center experience with 151 patients","volume":"41","author":"Vescovi \n              P,","year":"2012","unstructured":"Vescovi \n              P, \n            \n            \n              Merigo \n              E, \n            \n            \n              Meleti \n              M, \n            \n            \n              Manfredi \n              M, \n            \n            \n              Guidotti \n              R, \n            \n            \n              Nammour \n              S. \n            \n          \n          Bisphosphonates-related osteonecrosis of the jaws: a concise review of the literature and a report of a single-center experience with 151 patients. J Oral Pathol Med. 2012,41:214\u2013221."},{"key":"i1548-1336-43-1-51-Ruggiero1","series-title":"J Oral Maxillofac Surg","article-title":"American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws\u20142009 update","author":"Ruggiero \n              SL,","unstructured":"Ruggiero \n              SL, \n            \n            \n              Dodson \n              TB, \n            \n            \n              Assael \n              LA, \n            \n            \n              Landesberg \n              R, \n            \n            \n              Marx \n              RE, \n            \n            \n              Mehrotra \n              B. \n            \n          \n          American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws\u20142009 update. J Oral Maxillofac Surg. 2009,67:2\u201312."},{"key":"i1548-1336-43-1-51-Troeltzsch1","series-title":"J Can Dent Assoc","article-title":"Physiology and pharmacology of non-bisphosphonate drugs implicated in osteonecrosis of the jaw","author":"Troeltzsch \n              M,","year":"2012","unstructured":"Troeltzsch \n              M, \n            \n            \n              Woodlock \n              T, \n            \n            \n              Kriegelstein \n              S, \n            \n            \n              Steiner \n              T, \n            \n            \n              Messlinger \n              K, \n            \n            \n              Troeltzsch \n              M. \n            \n          \n          Physiology and pharmacology of non-bisphosphonate drugs implicated in osteonecrosis of the jaw. J Can Dent Assoc. 2012,78:c85."},{"key":"i1548-1336-43-1-51-Ikebe1","series-title":"Oral Science International","first-page":"1","article-title":"Pathophysiology of BRONJ: Drug-related osteoclastic disease of the jaw","volume":"10","author":"Ikebe \n              T.","year":"2013","unstructured":"Ikebe \n              T. \n            \n          \n          Pathophysiology of BRONJ: Drug-related osteoclastic disease of the jaw. Oral Science International. 2013;10:1\u20138."},{"key":"i1548-1336-43-1-51-Schipmann1","series-title":"J Oral Pathol Med","first-page":"587","article-title":"Osteopathology associated with bone resorption inhibitors \u2013 which role does Actinomyces play? A presentation of 51 cases with systematic review of the literature","volume":"42","author":"Schipmann \n              S,","year":"2013","unstructured":"Schipmann \n              S, \n            \n            \n              Metzler \n              P, \n            \n            \n              R\u00f6ssle \n              M, \n            \n            et al. \n          Osteopathology associated with bone resorption inhibitors \u2013 which role does Actinomyces play? A presentation of 51 cases with systematic review of the literature. J Oral Pathol Med. 2013;42:587\u2013593."},{"key":"i1548-1336-43-1-51-Stockmann1","series-title":"J Craniomaxillofac Surg","first-page":"71","article-title":"Major histocompatibility complex class II polymorphisms are associated with the development of anti-resorptive agent-induced osteonecrosis of the jaw","volume":"41","author":"Stockmann \n              P,","year":"2013","unstructured":"Stockmann \n              P, \n            \n            \n              Nkenke \n              E, \n            \n            \n              Englbrecht \n              M, \n            \n            et al. \n          Major histocompatibility complex class II polymorphisms are associated with the development of anti-resorptive agent-induced osteonecrosis of the jaw. J Craniomaxillofac Surg. 2013;41:71\u201375."},{"key":"i1548-1336-43-1-51-Ruggiero2","series-title":"J Oral Maxillofac Surg","first-page":"1938","article-title":"American Association of Oral and Maxillofacial Surgeons. Position paper on Medication-Related Osteonecrosis of the Jaw\u20142014 Update","volume":"72","author":"Ruggiero \n              SL,","year":"2014","unstructured":"Ruggiero \n              SL, \n            \n            \n              Dodson \n              TB, \n            \n            \n              Fantasia \n              J, \n            \n            et al. \n          American Association of Oral and Maxillofacial Surgeons. Position paper on Medication-Related Osteonecrosis of the Jaw\u20142014 Update. J Oral Maxillofac Surg. 2014;72:1938\u20131956."},{"key":"i1548-1336-43-1-51-Lo1","series-title":"J Oral Maxillofac Surg","first-page":"243","article-title":"Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure","volume":"68","author":"Lo \n              JC,","year":"2010","unstructured":"Lo \n              JC, \n            \n            \n              O'Ryan \n              FS, \n            \n            \n              Gordon \n              NP, \n            \n            et al. \n          Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure. J Oral Maxillofac Surg. 2010;68:243\u2013253."},{"key":"i1548-1336-43-1-51-Bell1","series-title":"J Oral Maxillofac Surg","first-page":"1022","article-title":"Oral bisphosphonates and dental implants: a retrospective study","volume":"66","author":"Bell \n              BM,","year":"2008","unstructured":"Bell \n              BM, \n            \n            \n              Bell \n              RE. \n            \n          \n          Oral bisphosphonates and dental implants: a retrospective study. J Oral Maxillofac Surg. 2008;66:1022\u20131024."},{"key":"i1548-1336-43-1-51-Goss1","series-title":"J Oral Maxillofac Surg","first-page":"337","article-title":"The nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in dental implant patients: a South Australian case series","volume":"68","author":"Goss \n              A,","year":"2010","unstructured":"Goss \n              A, \n            \n            \n              Bartold \n              M, \n            \n            \n              Sambrook \n              P, \n            \n            \n              Hawker \n              P. \n            \n          \n          The nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in dental implant patients: a South Australian case series. J Oral Maxillofac Surg. 2010;68:337\u2013343."},{"key":"i1548-1336-43-1-51-Grant1","series-title":"J Oral Maxillofac Surg","first-page":"223","article-title":"Outcomes of placing dental implants in patients taking oral bisphosphonates: a review of 115 cases","volume":"66","author":"Grant \n              BT,","year":"2008","unstructured":"Grant \n              BT, \n            \n            \n              Amenedo \n              C, \n            \n            \n              Freeman \n              K, \n            \n            \n              Kraut \n              RA. \n            \n          \n          Outcomes of placing dental implants in patients taking oral bisphosphonates: a review of 115 cases. J Oral Maxillofac Surg. 2008;66:223\u2013230."},{"key":"i1548-1336-43-1-51-Zahid1","series-title":"J Oral Implantol","first-page":"335","article-title":"Influence of bisphosphonates on alveolar bone loss around osseointegrated implants","volume":"37","author":"Zahid \n              TM,","year":"2011","unstructured":"Zahid \n              TM, \n            \n            \n              Wang \n              BY, \n            \n            \n              Cohen \n              RE. \n            \n          \n          Influence of bisphosphonates on alveolar bone loss around osseointegrated implants. J Oral Implantol. 2011;37:335\u2013346."},{"key":"i1548-1336-43-1-51-Shabestari1","series-title":"Clin Implant Dent Relat Res","first-page":"175","article-title":"Implant placement in patients with oral bisphosphonate therapy: a case series","volume":"12","author":"Shabestari \n              GO,","year":"2010","unstructured":"Shabestari \n              GO, \n            \n            \n              Shayesteh \n              YS, \n            \n            \n              Khojasteh \n              A, \n            \n            et al. \n          Implant placement in patients with oral bisphosphonate therapy: a case series. Clin Implant Dent Relat Res. 2010;12:175\u2013180."},{"key":"i1548-1336-43-1-51-Koka1","series-title":"J Prosthodont Res","first-page":"108","article-title":"Survival of dental implants in post-menopausal bisphosphonate users","volume":"54","author":"Koka \n              S,","year":"2010","unstructured":"Koka \n              S, \n            \n            \n              Babu \n              NM, \n            \n            \n              Norell \n              A. \n            \n          \n          Survival of dental implants in post-menopausal bisphosphonate users. J Prosthodont Res. 2010;54:108\u2013111."},{"key":"i1548-1336-43-1-51-Yip1","series-title":"J Clin Periodontol","first-page":"408","article-title":"Association between oral bisphosphonate use and dental implant failure among middle-aged women","volume":"39","author":"Yip \n              JK,","year":"2012","unstructured":"Yip \n              JK, \n            \n            \n              Borrell \n              LN, \n            \n            \n              Cho \n              SC, \n            \n            \n              Francisco \n              H, \n            \n            \n              Tarnow \n              DP. \n            \n          \n          Association between oral bisphosphonate use and dental implant failure among middle-aged women. J Clin Periodontol. 2012;39:408\u2013414."},{"key":"i1548-1336-43-1-51-Lazarovici1","series-title":"J Oral Maxillofac Surg","first-page":"790","article-title":"Bisphosphonate-related osteonecrosis of the jaw associated with dental implants","volume":"68","author":"Lazarovici \n              TS,","year":"2010","unstructured":"Lazarovici \n              TS, \n            \n            \n              Yahalom \n              R, \n            \n            \n              Taicher \n              S, \n            \n            \n              Schwartz-Arad \n              D, \n            \n            \n              Peleg \n              O, \n            \n            \n              Yarom \n              N. \n            \n          \n          Bisphosphonate-related osteonecrosis of the jaw associated with dental implants. J Oral Maxillofac Surg. 2010;68:790\u2013796."},{"key":"i1548-1336-43-1-51-Martin1","series-title":"J Oral Maxillofac Surg","first-page":"508","article-title":"Characteristics of implant failures in patients with a history of oral bisphosphonate therapy","volume":"68","author":"Martin \n              DC,","year":"2010","unstructured":"Martin \n              DC, \n            \n            \n              O'Ryan \n              FS, \n            \n            \n              Indresano \n              AT, \n            \n            et al. \n          Characteristics of implant failures in patients with a history of oral bisphosphonate therapy. J Oral Maxillofac Surg. 2010;68:508\u2013514."},{"key":"i1548-1336-43-1-51-Jeffcoat1","series-title":"J Oral Maxillofac Surg","first-page":"349","article-title":"Safety of oral bisphosphonates: controlled studies on alveolar bone","volume":"21","author":"Jeffcoat \n              MK.","year":"2006","unstructured":"Jeffcoat \n              MK. \n            \n          \n          Safety of oral bisphosphonates: controlled studies on alveolar bone. J Oral Maxillofac Surg. 2006;21:349\u2013353."},{"key":"i1548-1336-43-1-51-Madrid1","series-title":"Clin Oral Implants Res","first-page":"87","article-title":"What impact do systemically administrated bisphosphonates have on oral implant therapy? A systematic review","volume":"4","author":"Madrid \n              C,","year":"2009","unstructured":"Madrid \n              C, \n            \n            \n              Sanz \n              M. \n            \n          \n          What impact do systemically administrated bisphosphonates have on oral implant therapy? A systematic review. Clin Oral Implants Res. 2009;4:87\u201395."},{"key":"i1548-1336-43-1-51-Vahtsevanos1","series-title":"J Clin Oncol","first-page":"5356","article-title":"Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw","volume":"27","author":"Vahtsevanos \n              K,","year":"2009","unstructured":"Vahtsevanos \n              K, \n            \n            \n              Kyrgidis \n              A, \n            \n            \n              Verrou \n              E, \n            \n            et al. \n          Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw. J Clin Oncol. 2009;27:5356\u20135362."},{"key":"i1548-1336-43-1-51-Saad1","series-title":"Ann Oncol","first-page":"1341","article-title":"Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases","volume":"23","author":"Saad \n              F,","year":"2012","unstructured":"Saad \n              F, \n            \n            \n              Brown \n              JE, \n            \n            \n              Van Poznak \n              C, \n            \n            et al. \n          Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases. Ann Oncol. 2012;23:1341\u20131347."},{"key":"i1548-1336-43-1-51-Allen1","series-title":"J Oral Maxillofac Surg","first-page":"61","article-title":"The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data","volume":"67","author":"Allen \n              MR,","year":"2009","unstructured":"Allen \n              MR, \n            \n            \n              Burr \n              DB. \n            \n          \n          The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data. J Oral Maxillofac Surg. 2009;67:61\u201370."},{"key":"i1548-1336-43-1-51-Landesberg1","series-title":"Ann N Y Acad Sci","first-page":"62","article-title":"Potential pathophysiological mechanisms in osteonecrosis of the jaw","volume":"1218","author":"Landesberg \n              R,","year":"2011","unstructured":"Landesberg \n              R, \n            \n            \n              Woo \n              V, \n            \n            \n              Cremers \n              S, \n            \n            et al. \n          Potential pathophysiological mechanisms in osteonecrosis of the jaw. Ann N Y Acad Sci. 2011;1218:62\u201379."},{"key":"i1548-1336-43-1-51-Favia1","series-title":"Clin Implant Dent Relat Res","first-page":"58","article-title":"Osteonecrosis of the jaws after implant insertion. A clinical and histological case report","volume":"13","author":"Favia \n              G,","year":"2011","unstructured":"Favia \n              G, \n            \n            \n              Piattelli \n              A, \n            \n            \n              Sportelli \n              P, \n            \n            \n              Capodiferro \n              S, \n            \n            \n              Iezzi \n              G. \n            \n          \n          Osteonecrosis of the jaws after implant insertion. A clinical and histological case report. Clin Implant Dent Relat Res. 2011;13:58\u201363."},{"key":"i1548-1336-43-1-51-Degidi1","series-title":"J Osseointegr","article-title":"Histology of peri-implant bone in a failed implant retrieved from an area of osteonecrosis of the jaw in a patient suffering from multiple myeloma and treated with intravenous bisphosphonates","author":"Degidi \n              M,","year":"2012","unstructured":"Degidi \n              M, \n            \n            \n              Piattelli \n              A, \n            \n            \n              Marchetti \n              C, \n            \n            \n              Perrotti \n              V, \n            \n            \n              Iezzi \n              G. \n            \n          \n          Histology of peri-implant bone in a failed implant retrieved from an area of osteonecrosis of the jaw in a patient suffering from multiple myeloma and treated with intravenous bisphosphonates. J Osseointegr. 2012;1:15\u201320."}],"container-title":["Journal of Oral Implantology"],"original-title":[],"link":[{"URL":"https:\/\/joi.kglmeridian.com\/view\/journals\/orim\/43\/1\/article-p51.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/joi\/article-pdf\/43\/1\/51\/2058118\/aaid-joi-16-00057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/joi.kglmeridian.com\/downloadpdf\/journals\/orim\/43\/1\/article-p51.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/joi.kglmeridian.com\/downloadpdf\/journals\/orim\/43\/1\/article-p51.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:13:06Z","timestamp":1752192786000},"score":1,"resource":{"primary":{"URL":"https:\/\/joi.kglmeridian.com\/view\/journals\/orim\/43\/1\/article-p51.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":27,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1563\/aaid-joi-16-00057","relation":{},"ISSN":["0160-6972","1548-1336"],"issn-type":[{"value":"0160-6972","type":"print"},{"value":"1548-1336","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}