{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:30:11Z","timestamp":1760646611710,"version":"3.41.2"},"reference-count":29,"publisher":"American Academy of Implant Dentistry","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Numerous grafting materials have been used to augment the maxillary sinus floor for long-term stability and success for implant-supported prosthesis. To enhance bone formation, adjunctive blood-born growth factor sources have gained popularity during the recent years. The present study compared the use of platelet-rich fibrin (PRF) and bovine-autogenous bone mixture for maxillary sinus floor elevation. A split-face model was used to apply 2 different filling materials for maxillary sinus floor elevation in 22 healthy adult sheep. In group 1, bovine and autogenous bone mixture; and in group 2, PRF was used. The animals were killed at 3, 6, and 9 months. Histologic and histomorphologic examinations revealed new bone formation in group 1 at the third and sixth months. In group 2, new bone formation was observed only at the sixth month, and residual PRF remnants were identified. At the ninth month, host bone and new bone could not be distinguished from each other in group 1, and bone formation was found to be proceeding in group 2. PRF remnants still existed at the ninth month. In conclusion, bovine bone and autogenous bone mixture is superior to PRF as a grafting material in sinus-lifting procedures.<\/jats:p>","DOI":"10.1563\/aaid-joi-d-16-00104","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T11:38:13Z","timestamp":1489405093000},"page":"194-201","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of Bovine Bone-Autogenic Bone Mixture Versus Platelet-Rich Fibrin for Maxillary Sinus Grafting: Histologic and Histomorphologic Study"],"prefix":"10.1563","volume":"43","author":[{"given":"Hakan","family":"Ocak","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes University, Kayseri, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nukhet","family":"Kutuk","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes University, Kayseri, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umut","family":"Demetoglu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Adnan Menderes University, Ayd\u0131n, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Balc\u0131oglu","sequence":"additional","affiliation":[{"name":"Department of Histology, Faculty of Medicine, Erciyes University, Kayseri, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saim","family":"Ozdamar","sequence":"additional","affiliation":[{"name":"Department of Histology, Faculty of Medicine, Erciyes University, Kayseri, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Alkan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"434","reference":[{"key":"i1548-1336-43-3-194-b01","series-title":"J Korean Assoc Oral Maxillofac Surg","first-page":"274","article-title":"Hyun-Young Cho, et al. Assessment of the autogenous bone graft for sinus elevation","volume":"39","author":"Peng \n              W,","year":"2013","unstructured":"Peng \n              W, \n            \n            \n              Il-Kyu \n              Kim, \n            \n          \n          Hyun-Young Cho, et al. Assessment of the autogenous bone graft for sinus elevation. J Korean Assoc Oral Maxillofac Surg. 2013;39:274\u2013282."},{"key":"i1548-1336-43-3-194-b02","series-title":"Int J Oral Maxillofac Implants","first-page":"175","article-title":"A review of survival rates for implants placed in grafted maxillary sinuses using meta-analysis","volume":"13","author":"Tong \n              DC,","year":"1998","unstructured":"Tong \n              DC, \n            \n            \n              Rioux \n              K, \n            \n            \n              Drangsholt \n              M, \n            \n            \n              Beirne \n              OR. \n            \n          \n          A review of survival rates for implants placed in grafted maxillary sinuses using meta-analysis. Int J Oral Maxillofac Implants. 1998;13:175\u2013182."},{"key":"i1548-1336-43-3-194-b03","series-title":"J Oral Maxillofac Surg","first-page":"1098","article-title":"Osteotome sinus floor elevation technique without grafting material and immediate implant placement in atrophic posterior maxilla: report of 2 cases","volume":"67","author":"Nedir \n              R,","year":"2009","unstructured":"Nedir \n              R, \n            \n            \n              Nurdin \n              N, \n            \n            \n              Szmukler-Moncler \n              S, \n            \n            \n              Bischof \n              M. \n            \n          \n          Osteotome sinus floor elevation technique without grafting material and immediate implant placement in atrophic posterior maxilla: report of 2 cases. J Oral Maxillofac Surg2009;67:1098\u20131103."},{"key":"i1548-1336-43-3-194-b04","series-title":"Tissue Eng Part B Rev","first-page":"493","article-title":"A meta-analysis of histomorphometric results and graft healing time of various bio- materials compared to autologous bone used as sinus floor augmentation material in humans","volume":"16","author":"Klijn \n              RJ,","year":"2010","unstructured":"Klijn \n              RJ, \n            \n            \n              Meijer \n              GJ, \n            \n            \n              Bronkhorst \n              EM, \n            \n            \n              Jansen \n              JA. \n            \n          \n          A meta-analysis of histomorphometric results and graft healing time of various bio- materials compared to autologous bone used as sinus floor augmentation material in humans. Tissue Eng Part B Rev. 2010;16:493\u2013507."},{"key":"i1548-1336-43-3-194-b05","series-title":"Clin Implant Dent Relat Res","first-page":"893","article-title":"Nongrafted sinus floor elevation with a space-maintaining titanium mesh: case-series study on four patients","author":"Atef, \n              M,","year":"2014","unstructured":"Atef, \n              M, \n            \n            \n              Hakam \n              M, \n            \n            \n              ElFaramawey \n              MI, \n            \n            \n              Abou-ElFetouh \n              A, \n            \n            \n              Ekram \n              M. \n            \n          \n          Nongrafted sinus floor elevation with a space-maintaining titanium mesh: case-series study on four patients. Clin Implant Dent Relat Res. 2014;893\u2013903."},{"key":"i1548-1336-43-3-194-b06","series-title":"J Oral Maxillofac Res","first-page":"e1","article-title":"Graft-free sinus augmentation procedure: a literature review","volume":"5","author":"Pinchasov \n              G,","year":"2014","unstructured":"Pinchasov \n              G, \n            \n            \n              Juodzbalys \n              G. \n            \n          \n          Graft-free sinus augmentation procedure: a literature review. J Oral Maxillofac Res. 2014;5:e1."},{"key":"i1548-1336-43-3-194-b07","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol","first-page":"583","article-title":"A comparative study of the effectiveness of sinus bone grafting with recombinant human bone morphogenetic protein 2\u2013coated tricalcium phosphate and platelet-rich fibrin\u2013mixed tricalcium phosphate in rabbits","volume":"113","author":"Kim \n              BJ,","year":"2012","unstructured":"Kim \n              BJ, \n            \n            \n              Kwon \n              TK, \n            \n            \n              Baek \n              HS, \n            \n            et al. \n          A comparative study of the effectiveness of sinus bone grafting with recombinant human bone morphogenetic protein 2\u2013coated tricalcium phosphate and platelet-rich fibrin\u2013mixed tricalcium phosphate in rabbits. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:583\u2013592."},{"key":"i1548-1336-43-3-194-b08","series-title":"Int J Periodontics Restorative Dent","first-page":"e41","article-title":"Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial","volume":"32","author":"Jankovic \n              S,","year":"2012","unstructured":"Jankovic \n              S, \n            \n            \n              Aleksic \n              Z, \n            \n            \n              Klokkevold \n              P, \n            \n            et al. \n          Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial. Int J Periodontics Restorative Dent. 2012;32:e41\u2013e50."},{"issue":"2013","key":"i1548-1336-43-3-194-b09","series-title":"ISRN Biomat","first-page":"627367","article-title":"Platelet-rich fibrin as a biofuel for tissue regeneration","author":"Khiste \n              SV,","year":"2013","unstructured":"Khiste \n              SV, \n            \n            \n              Tari \n              RN. \n            \n          \n          Platelet-rich fibrin as a biofuel for tissue regeneration. ISRN Biomat.2013(2013):627367."},{"key":"i1548-1336-43-3-194-b10","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"E51","article-title":"Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates?","volume":"3","author":"Dohan \n              DM,","year":"2006","unstructured":"Dohan \n              DM, \n            \n            \n              Choukroun \n              H, \n            \n            \n              Diss \n              A, \n            \n            et al. \n          Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates?\n          Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101;3:E51\u2013E55."},{"key":"i1548-1336-43-3-194-b11","series-title":"Int J Oral Maxillofac Implants","first-page":"635","article-title":"A clinical and histologic evaluation of implant integration in the posterior maxilla after sinus floor augmentation with autogenous bone, bovine hydroxyapatite, or a 20:80 mixture","volume":"17","author":"Hallman \n              M,","year":"2002","unstructured":"Hallman \n              M, \n            \n            \n              Sennerby \n              L, \n            \n            \n              Lundgren \n              S. \n            \n          \n          A clinical and histologic evaluation of implant integration in the posterior maxilla after sinus floor augmentation with autogenous bone, bovine hydroxyapatite, or a 20:80 mixture. Int J Oral Maxillofac Implants. 2002;17:635\u2013643."},{"key":"i1548-1336-43-3-194-b12","series-title":"Clin Implant Dent Relat Res","first-page":"166","article-title":"A literature review on biomaterials in sinus augmentation procedures","volume":"9","author":"Browaeys \n              H,","year":"2007","unstructured":"Browaeys \n              H, \n            \n            \n              Bouvry \n              P, \n            \n            \n              De Bruyn \n              H. \n            \n          \n          A literature review on biomaterials in sinus augmentation procedures. Clin Implant Dent Relat Res. 2007;9:166\u201377."},{"key":"i1548-1336-43-3-194-b13","series-title":"Int J Oral Maxillofac Implants","first-page":"713","article-title":"Sinus floor elevation using a bovine bone mineral (Bio-Oss) with or without the concomitant use of a bilayered collagen barrier (Bio-Gide): a clinical report of immediate and delayed implant placement","volume":"16","author":"Tawil \n              G,","year":"2001","unstructured":"Tawil \n              G, \n            \n            \n              Mawla \n              M. \n            \n          \n          Sinus floor elevation using a bovine bone mineral (Bio-Oss) with or without the concomitant use of a bilayered collagen barrier (Bio-Gide): a clinical report of immediate and delayed implant placement. Int J Oral Maxillofac Implants.2001;16:713\u2013721."},{"key":"i1548-1336-43-3-194-b14","series-title":"Clin Orthopaed","first-page":"28","article-title":"The biology of bone graft repair","volume":"174","author":"Burchardt \n              H.","year":"1983","unstructured":"Burchardt \n              H. \n            \n          \n          The biology of bone graft repair. Clin Orthopaed. 1983;174:28\u201342."},{"key":"i1548-1336-43-3-194-b15","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"e21","article-title":"Evaluation of sinus bone resorption and marginal bone loss after sinus bone grafting and implant placement","volume":"107","author":"Kim \n              YK,","year":"2009","unstructured":"Kim \n              YK, \n            \n            \n              Yun \n              PY, \n            \n            \n              Kim \n              SG, \n            \n            \n              Kim \n              BS, \n            \n            \n              Ong \n              JL. \n            \n          \n          Evaluation of sinus bone resorption and marginal bone loss after sinus bone grafting and implant placement. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:e21\u2013e28."},{"key":"i1548-1336-43-3-194-b16","series-title":"Clin Oral Implants Res","first-page":"339","article-title":"A clinical long-term radiographic evaluation of graft height changes after maxillary sinus floor augmentation with a 2:1 autogenous bone\/xenograft mixture and simultaneous placement of dental implants","volume":"15","author":"Hatano \n              N,","year":"2004","unstructured":"Hatano \n              N, \n            \n            \n              Shimizu \n              Y, \n            \n            \n              Ooya \n              K. \n            \n          \n          A clinical long-term radiographic evaluation of graft height changes after maxillary sinus floor augmentation with a 2:1 autogenous bone\/xenograft mixture and simultaneous placement of dental implants. Clin Oral Implants Res. 2004;15:339\u2013345."},{"key":"i1548-1336-43-3-194-b17","series-title":"Clin Implant Dent Relat Res","first-page":"11","article-title":"Bone reformation and implant integration following maxillary sinus membrane elevation: an experimental study in primates","volume":"8","author":"Palma \n              VC,","year":"2006","unstructured":"Palma \n              VC, \n            \n            \n              Magro-Filho \n              O, \n            \n            \n              de Oliveria \n              JA, \n            \n            \n              Lundgren \n              S, \n            \n            \n              Salata \n              LA, \n            \n            \n              Sennerby \n              L. \n            \n          \n          Bone reformation and implant integration following maxillary sinus membrane elevation: an experimental study in primates. Clin Implant Dent Relat Res. 2006;8:11\u201324."},{"key":"i1548-1336-43-3-194-b18","series-title":"Clin Implant Dent Relat Res","first-page":"78","article-title":"Spontaneous bone formation in themaxillary sinus after removal of a cyst: coincidence or consequence?","volume":"5","author":"Lundgren \n              S,","year":"2003","unstructured":"Lundgren \n              S, \n            \n            \n              Andersson \n              S, \n            \n            \n              Sennerby \n              L. \n            \n          \n          Spontaneous bone formation in themaxillary sinus after removal of a cyst: coincidence or consequence?\n          Clin Implant Dent Relat Res. 2003;5:78\u201381."},{"key":"i1548-1336-43-3-194-b19","series-title":"Clin Implant Dent Relat Res","first-page":"165","article-title":"Bone reformation with sinus membrane elevation: a new surgical technique for maxillary sinus floor augmentation","volume":"6","author":"Lundgren \n              S,","year":"2004","unstructured":"Lundgren \n              S, \n            \n            \n              Andersson \n              S, \n            \n            \n              Gualini \n              F, \n            \n            \n              Sennerby \n              L. \n            \n          \n          Bone reformation with sinus membrane elevation: a new surgical technique for maxillary sinus floor augmentation. Clin Implant Dent Relat Res. 2004;6:165\u2013173."},{"key":"i1548-1336-43-3-194-b20","series-title":"Calcif Tissue Int","first-page":"138","article-title":"The Schneiderian membrane contains osteoprogenitor cells: in vivo and in vitro study","volume":"84","author":"Srouji \n              S,","year":"2009","unstructured":"Srouji \n              S, \n            \n            \n              Kizhner \n              T, \n            \n            \n              Ben David \n              D, \n            \n            \n              Riminucci \n              M, \n            \n            \n              Bianco \n              P, \n            \n            \n              Livne \n              E. \n            \n          \n          The Schneiderian membrane contains osteoprogenitor cells: in vivo and in vitro study. Calcif Tissue Int. 2009;84:138\u2013145."},{"key":"i1548-1336-43-3-194-b21","series-title":"Int J Oral Maxillofac Surg","first-page":"793","article-title":"The innate osteogenic potential of the maxillary sinus (Schneiderian) membrane: an ectopic tissue transplant model simulating sinus lifting","volume":"39","author":"Srouji \n              S,","year":"2010","unstructured":"Srouji \n              S, \n            \n            \n              Ben-David \n              D, \n            \n            \n              Lotan \n              R, \n            \n            \n              Riminucci \n              M, \n            \n            \n              Livne \n              E, \n            \n            \n              Bianco \n              P. \n            \n          \n          The innate osteogenic potential of the maxillary sinus (Schneiderian) membrane: an ectopic tissue transplant model simulating sinus lifting. Int J Oral Maxillofac Surg. 2010;39:793\u2013801."},{"key":"i1548-1336-43-3-194-b22","series-title":"Anatomic Rec","first-page":"426","article-title":"In vitro modeling of the bone\/implant interface","volume":"245","author":"Dav\u0131es \n              JE.","year":"2006","unstructured":"Dav\u0131es \n              JE. \n            \n          \n          In vitro modeling of the bone\/implant interface. Anatomic Rec. 2006;245:426\u2013445."},{"key":"i1548-1336-43-3-194-b23","series-title":"Clin Oral Implant Res","first-page":"100","article-title":"Use of a titanium device in lateral sinus floor elevation: an experimental study in monkeys","volume":"23","author":"Schweikert \n              M,","year":"2012","unstructured":"Schweikert \n              M, \n            \n            \n              Botticelli \n              D, \n            \n            \n              De Oliveira \n              JA, \n            \n            \n              Scala \n              A, \n            \n            \n              Salata \n              LA, \n            \n            \n              Lang \n              NP. \n            \n          \n          Use of a titanium device in lateral sinus floor elevation: an experimental study in monkeys. Clin Oral Implant Res. 2012;23:100\u2013105."},{"key":"i1548-1336-43-3-194-b24","series-title":"Clin Oral Implants Res","first-page":"175","article-title":"Lack of influence of the Schneiderian membrane in forming new boneapical to implants simultaneously installed with sinus floor elevation: anexperimental study in monkeys","volume":"23","author":"Scala \n              A,","year":"2012","unstructured":"Scala \n              A, \n            \n            \n              Botticelli \n              D, \n            \n            \n              Faeda \n              RS, \n            \n            \n              Garcia Rangel \n              I\n              Jr, \n            \n            \n              Am\u00e9rico de Oliveira \n              J, \n            \n            \n              Lang \n              NP. \n            \n          \n          Lack of influence of the Schneiderian membrane in forming new boneapical to implants simultaneously installed with sinus floor elevation: anexperimental study in monkeys. Clin Oral Implants Res. 2012 ;23:175\u2013181."},{"key":"i1548-1336-43-3-194-b25","series-title":"Implantodontie","first-page":"55","article-title":"Une opportuniteen paro-implantologie: le PRF","volume":"42","author":"Choukroun \n              J,","year":"2001","unstructured":"Choukroun \n              J, \n            \n            \n              Adda \n              F, \n            \n            \n              Schoeffler \n              C, \n            \n            \n              Vervelle \n              A. \n            \n          \n          Une opportuniteen paro-implantologie: le PRF. Implantodontie. 2001;42:55\u201362."},{"key":"i1548-1336-43-3-194-b26","series-title":"J Periodontol","first-page":"2056","article-title":"Dohan Ehrenfest DM. Sinus floor augmentation with simultaneous implant placement using Choukroun's platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months","volume":"80","author":"Mazor \n              Z,","year":"2009","unstructured":"Mazor \n              Z, \n            \n            \n              Horowitz \n              RA, \n            \n            \n              Del Corso \n              M, \n            \n            \n              Prasad \n              HS, \n            \n            \n              Rohrer \n              MD, \n            \n          \n          Dohan Ehrenfest DM. Sinus floor augmentation with simultaneous implant placement using Choukroun's platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J Periodontol. 2009;80:2056\u20132064."},{"key":"i1548-1336-43-3-194-b27","series-title":"Implant Dent","first-page":"2","article-title":"Dohan Ehrenfest DM. Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte- and platelet-rich fibrin as sole grafting material: a six-year experience","volume":"20","author":"Simonpieri \n              A,","year":"2011","unstructured":"Simonpieri \n              A, \n            \n            \n              Choukroun \n              J, \n            \n            \n              Corso \n              MD, \n            \n            \n              Sammartino \n              G, \n            \n          \n          Dohan Ehrenfest DM. Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte- and platelet-rich fibrin as sole grafting material: a six-year experience. Implant Dent. 2011;20:2\u201312."},{"key":"i1548-1336-43-3-194-b28","series-title":"Implant Dent","first-page":"389","article-title":"Bone regeneration in the maxillary sinus using an autologous fibrin-rich block with concentrated growth factors alone","volume":"20","author":"Sohn \n              DS,","year":"2011","unstructured":"Sohn \n              DS, \n            \n            \n              Heo \n              JU, \n            \n            \n              Kwak \n              DH, \n            \n            et al. \n          Bone regeneration in the maxillary sinus using an autologous fibrin-rich block with concentrated growth factors alone. Implant Dent. 2011;20:389\u2013395."},{"key":"i1548-1336-43-3-194-b29","series-title":"J Cranio-Maxillo-Facial Surg","first-page":"990","article-title":"Simultaneous sinus lift and implantation using platelet-rich fibrin as sole grafting material","volume":"42","author":"Jeong \n              S-M,","year":"2014","unstructured":"Jeong \n              S-M, \n            \n            \n              Lee \n              CU, \n            \n            \n              Son \n              JS, \n            \n            et al. \n          Simultaneous sinus lift and implantation using platelet-rich fibrin as sole grafting material. J Cranio-Maxillo-Facial Surg. 2014;42:990\u2013994."}],"container-title":["Journal of Oral Implantology"],"original-title":[],"link":[{"URL":"https:\/\/joi.kglmeridian.com\/view\/journals\/orim\/43\/3\/article-p194.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/joi\/article-pdf\/43\/3\/194\/2038233\/aaid-joi-d-16-00104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/joi.kglmeridian.com\/downloadpdf\/journals\/orim\/43\/3\/article-p194.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/joi.kglmeridian.com\/downloadpdf\/journals\/orim\/43\/3\/article-p194.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:15:00Z","timestamp":1752192900000},"score":1,"resource":{"primary":{"URL":"https:\/\/joi.kglmeridian.com\/view\/journals\/orim\/43\/3\/article-p194.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":29,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1563\/aaid-joi-d-16-00104","relation":{},"ISSN":["0160-6972","1548-1336"],"issn-type":[{"type":"print","value":"0160-6972"},{"type":"electronic","value":"1548-1336"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}