{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:40:02Z","timestamp":1752194402674,"version":"3.41.2"},"reference-count":20,"publisher":"American Academy of Implant Dentistry","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>The purpose of this nonrandom retrospective cohort study was to evaluate the impact of perioperative antibiotic on early outcomes, including postoperative pain, swelling, bleeding, and cyanosis, in patients undergoing dental implant placement before prosthetic loading. Seventy-five patients (45 men, 30 women) who had completed dental implant placement were included in the study. Patients who used perioperative antibiotics comprised the experimental group, and those who did not comprised the control group. The experimental group received 2 g amoxicillin + clavulanic acid 1 hour before surgery and 1 g amoxicillin + clavulanic acid twice a day for 5 days after surgery. The control group received no perioperative antibiotic therapy. Data on pain, swelling, bleeding, cyanosis, flap dehiscence, suppuration, and implant failure were analyzed on postoperative days 2, 7, and 14 and at week 12. No statistically significant difference was detected between the 2 groups with regard to pain and swelling on postoperative days 2, 7, and 14 and week 12 (<jats:italic>P &gt;<\/jats:italic> .05), while the severity of pain and swelling were greater on day 2 than on days 7 and 14 and week 12 in both groups (<jats:italic>P =<\/jats:italic> .001 and <jats:italic>P &lt;<\/jats:italic> .05, respectively). Similarly, no significant difference was found between the 2 groups with regard to postoperative bleeding and cyanosis. Although flap dehiscence was more severe on day 7 in the experimental group, no significant difference was found between the 2 groups with regard to the percentage of flap dehiscence assessed at other time points. Within the limitations of the study, it has been demonstrated that antibiotic use has no effect on implant failure rates in dental implant surgery with a limited number of implants. We conclude that perioperative antibiotic use may not be required in straightforward implant placement procedures. Further randomized controlled clinical studies with more patients and implants are needed to substantiate our findings.<\/jats:p>","DOI":"10.1563\/aaid-joi-d-19-00282","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T17:02:33Z","timestamp":1594746153000},"page":"135-139","source":"Crossref","is-referenced-by-count":1,"title":["Is Perioperative Antibiotic Necessary in Straightforward Implant Placement Procedures?"],"prefix":"10.1563","volume":"47","author":[{"given":"El\u00e7in","family":"Bedelo\u011flu","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Istanbul Ayd\u0131n University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Gaziantep University, Gaziantep, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cenker Zeki","family":"Koyuncuo\u011flu","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology, \u0130stanbul Ayd\u0131n University, Istanbul Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"434","reference":[{"key":"i1548-1336-47-2-135-b01","series-title":"J Oral Implantol","first-page":"691","article-title":"one A, Brgnami F. 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A systematic review and network meta-analysis","volume":"46","author":"Romandini","year":"2019","unstructured":"Romandini\n              M,\n            \n            \n              Tullio\n              ID,\n            \n            \n              Congedi\n              F,\n            \n            et al.\n\t\t\t\t\t\n          Antibiotic prophylaxis at dental implant placement: Which is the best protocol? A systematic review and network meta-analysis.\n\t\t\t\t\tJ Clin Periodontol.\n\t\t\t\t\t2019:\n\t\t\t\t\t46:\n\t\t\t\t\t382\u2013\n\t\t\t\t\t395."},{"key":"i1548-1336-47-2-135-b11","series-title":"Clin Oral Investig","first-page":"1525","article-title":"Antibiotic prophylaxis may not be indicated for prevention of dental implant infections in healthy patients. A systematic review and meta-analysis","volume":"23","author":"Khouly","year":"2019","unstructured":"Khouly\n              I,\n            \n            \n              Braun\n              RS,\n            \n            \n              Chambrone\n              L.\n            \n          \n          Antibiotic prophylaxis may not be indicated for prevention of dental implant infections in healthy patients. 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A prospective double blind randomized controlled clinical trial","volume":"25","author":"Nolan","year":"2014","unstructured":"Nolan\n              R,\n            \n            \n              Kemmoona\n              M,\n            \n            \n              Polyzois\n              I,\n            \n            \n              Claffey\n              N.\n            \n          \n          The influence of prophylactic antibiotic administration on post-operative morbidity in dental implant surgery. A prospective double blind randomized controlled clinical trial.\n\t\t\t\t\tClin Oral Implants Res.\n\t\t\t\t\t2014;\n\t\t\t\t\t25:\n\t\t\t\t\t252\u2013\n\t\t\t\t\t259."},{"key":"i1548-1336-47-2-135-b18","series-title":"J Craniomaxillofac Surg","first-page":"722","article-title":"Which antibiotic regimen prevents implant failure or infection after dental implant surgery? A systematic review and meta-analysis","volume":"46","author":"S\u00e1nchez","year":"2018","unstructured":"S\u00e1nchez\n              FR,\n            \n            \n              Andr\u00e9s\n              CR,\n            \n            \n              Arteagoitia\n              I.\n            \n          \n          Which antibiotic regimen prevents implant failure or infection after dental implant surgery? A systematic review and meta-analysis.\n\t\t\t\t\tJ Craniomaxillofac Surg.\n\t\t\t\t\t2018;\n\t\t\t\t\t46:\n\t\t\t\t\t722\u2013\n\t\t\t\t\t736."},{"key":"i1548-1336-47-2-135-b19","series-title":"J Clin Med Res","first-page":"1","article-title":"Effects of antibiotics on dental implants: a review","volume":"4","author":"Ahmad","year":"2012","unstructured":"Ahmad\n              N,\n            \n            \n              Saad\n              N.\n            \n          \n          Effects of antibiotics on dental implants: a review.\n\t\t\t\t\tJ Clin Med Res.\n\t\t\t\t\t2012;\n\t\t\t\t\t4:\n\t\t\t\t\t1."},{"issue":"(suppl 1)","key":"i1548-1336-47-2-135-b20","series-title":"J Pharm Bioallied Sci","first-page":"S28","article-title":"Antibiotics in dental implants: a review of literature","volume":"8","author":"Surapaneni","year":"2016","unstructured":"Surapaneni\n              H,\n            \n            \n              Yalamanchili\n              PS,\n            \n            \n              Basha\n              MH,\n            \n            \n              Potluri\n              S,\n            \n            \n              Elisetti\n              N,\n            \n            \n              Kumar\n              MK.\n            \n          \n          Antibiotics in dental implants: a review of literature.\n\t\t\t\t\tJ Pharm Bioallied Sci.\n\t\t\t\t\t2016;\n\t\t\t\t\t8(suppl 1):\n\t\t\t\t\tS28\u2013\n\t\t\t\t\tS31."}],"container-title":["Journal of Oral Implantology"],"original-title":[],"link":[{"URL":"https:\/\/joi.kglmeridian.com\/view\/journals\/orim\/47\/2\/article-p135.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/joi\/article-pdf\/47\/2\/135\/2831526\/i1548-1336-47-2-135.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/joi.kglmeridian.com\/downloadpdf\/journals\/orim\/47\/2\/article-p135.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/joi.kglmeridian.com\/downloadpdf\/journals\/orim\/47\/2\/article-p135.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:17:42Z","timestamp":1752193062000},"score":1,"resource":{"primary":{"URL":"https:\/\/joi.kglmeridian.com\/view\/journals\/orim\/47\/2\/article-p135.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":20,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1563\/aaid-joi-d-19-00282","relation":{},"ISSN":["1548-1336","0160-6972"],"issn-type":[{"type":"electronic","value":"1548-1336"},{"type":"print","value":"0160-6972"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}