{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:01:07Z","timestamp":1752278467431,"version":"3.41.2"},"reference-count":21,"publisher":"American Academy of Implant Dentistry","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>The purpose of this case report was to present a rare clinical case of successful new dental implant installation in the site of previously healed medication-related osteonecrosis of the jaw (MRONJ). An 80-year-old female patient with history of oral bisphosphonate (BP) therapy presented with pain and swelling of gingiva in the right posterior mandible. One of the 3 implants placed 15 years ago in the right mandibular posterior area was removed 6 months before the visit to our hospital, which led to worsening of the symptoms. After clinical and radiographic examination, the patient was diagnosed with stage 2 MRONJ. Along with antibiotic therapy, the patient underwent surgical intervention via sequestrectomy and removal of the remaining 2 implants. Adequate soft and hard tissue healing without any complications and signs of recurrence was confirmed, and implant installation with simultaneous bone grafting and prosthesis fabrication were done in the explantation sites of MRONJ. By the 7-year follow-up, no implant failure has been observed, and installation of implants was successful in the previously healed MRONJ site. Dental implant installation is possible in a patient with history of failed implant due to MRONJ. However, a careful treatment planning is needed before implantation in a previously healed site of MRONJ to reduce the potential risks of MRONJ recurrence and implant failure.<\/jats:p>","DOI":"10.1563\/aaid-joi-d-20-00295","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T01:20:02Z","timestamp":1680830402000},"page":"117-123","source":"Crossref","is-referenced-by-count":4,"title":["Successful New Dental Implant Installation in a Healed Site of Medication-Related Osteonecrosis of the Jaw: A Case Report"],"prefix":"10.1563","volume":"49","author":[{"given":"Ju-Young","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je-Uk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"434","reference":[{"key":"i1548-1336-49-2-117-b01","series-title":"Eur J Oral Implantol","first-page":"S155","article-title":"A systematic review of survival of single implants as presented in longitudinal studies with a follow-up of at least 10 years","volume":"9","author":"Hjalmarsson","year":"2016","unstructured":"Hjalmarsson\n              L\n            ,\n\t\t\t\t\t\tGheisarifarM,\n\t\t\t\t\t\tJemtT.\n\t\t\t\t\t\n          A systematic review of survival of single implants as presented in longitudinal studies with a follow-up of at least 10 years.\n\t\t\t\t\tEur J Oral Implantol.\n\t\t\t\t\t2016;9:\n\t\t\t\t\tS155\u2013S162."},{"key":"i1548-1336-49-2-117-b02","series-title":"J Craniofac Surg","first-page":"697","article-title":"Medication-related osteonecrosis of the jaw around dental implants: implant surgery-triggered or implant presence-triggered osteonecrosis?","volume":"27","author":"Giovannacci","year":"2016","unstructured":"Giovannacci\n              I\n            ,\n\t\t\t\t\t\tMeletiM,\n\t\t\t\t\t\tManfrediM,\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n          Medication-related osteonecrosis of the jaw around dental implants: implant surgery-triggered or implant presence-triggered osteonecrosis?\n          \n            J Craniofac Surg\n          .\n\t\t\t\t\t2016;27:\n\t\t\t\t\t697\u2013701."},{"key":"i1548-1336-49-2-117-b03","series-title":"Clin Oral Implants Res","first-page":"943","article-title":"Dental implants treatment outcomes in patient under active therapy with alendronate: 3-year follow-up results of a multicenter prospective observational study","volume":"27","author":"Tallarico","year":"2016","unstructured":"Tallarico\n              M\n            ,\n\t\t\t\t\t\tCanulloL,\n\t\t\t\t\t\tXhanariE,\n\t\t\t\t\t\tMeloniSM.\n\t\t\t\t\t\n          Dental implants treatment outcomes in patient under active therapy with alendronate: 3-year follow-up results of a multicenter prospective observational study.\n\t\t\t\t\tClin Oral Implants Res.\n\t\t\t\t\t2016;27:\n\t\t\t\t\t943\u2013949."},{"key":"i1548-1336-49-2-117-b04","series-title":"Int J Implant Dent","first-page":"9","article-title":"Dental implants in patients treated with antiresorptive medication\u2014a systematic literature review","volume":"2","author":"Walter","year":"2016","unstructured":"Walter\n              C\n            ,\n\t\t\t\t\t\tAl-NawasB,\n\t\t\t\t\t\tWolffT,\n\t\t\t\t\t\tSchiegnitzE,\n\t\t\t\t\t\tGr\u00f6tzKA.\n\t\t\t\t\t\n          Dental implants in patients treated with antiresorptive medication\u2014a systematic literature review.\n\t\t\t\t\tInt J Implant Dent.\n\t\t\t\t\t2016;2:\n\t\t\t\t\t9."},{"key":"i1548-1336-49-2-117-b05","series-title":"Implant Dent","first-page":"353","article-title":"Medical contraindications to implant therapy: part I: absolute contraindications","volume":"15","author":"Hwang","year":"2006","unstructured":"Hwang\n              D\n            ,\n\t\t\t\t\t\tWangHL.\n\t\t\t\t\t\n          Medical contraindications to implant therapy: part I: absolute contraindications.\n\t\t\t\t\tImplant Dent.\n\t\t\t\t\t2006;15:\n\t\t\t\t\t353\u2013360."},{"key":"i1548-1336-49-2-117-b06","series-title":"J Oral Maxillofac Surg","first-page":"1938","article-title":"American Association of Oral and Maxillofacial Surgeons. 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A retrospective study","volume":"27","author":"Memon","year":"2012","unstructured":"Memon\n              S\n            ,\n\t\t\t\t\t\tWeltmanRL,\n\t\t\t\t\t\tKatancikJA.\n\t\t\t\t\t\n          Oral bisphosphonates: early endosseous dental implant success and crestal bone changes. 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A systematic review","volume":"20","author":"Madrid","year":"2009","unstructured":"Madrid\n              C\n            ,\n\t\t\t\t\t\tSanzM.\n\t\t\t\t\t\n          What impact do systemically administrated bisphosphonates have on oral implant therapy? A systematic review.\n\t\t\t\t\tClin Oral Implants Res.\n\t\t\t\t\t2009;20:\n\t\t\t\t\t87\u201395."},{"key":"i1548-1336-49-2-117-b16","series-title":"Clin Oral Implants Res","first-page":"e38","article-title":"What is the impact of bisphosphonate therapy upon dental implant survival? A systematic review and meta-analysis","volume":"27","author":"Ata-Ali","year":"2014","unstructured":"Ata-Ali\n              J\n            ,\n\t\t\t\t\t\tAta-AliF,\n\t\t\t\t\t\tPenarrocha-OltraD,\n\t\t\t\t\t\tGalindo-MorenoP.\n\t\t\t\t\t\n          What is the impact of bisphosphonate therapy upon dental implant survival? 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A cross-sectional study in a matched collective","volume":"19","author":"Wagner","year":"2017","unstructured":"Wagner\n              F\n            ,\n\t\t\t\t\t\tSchuderK,\n\t\t\t\t\t\tHofM,\n\t\t\t\t\t\tHeubererS,\n\t\t\t\t\t\tSeemannR,\n\t\t\t\t\t\tDvorakG.\n\t\t\t\t\t\n          Does osteoporosis influence the marginal peri-implant bone level in female patients? 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