{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:56:46Z","timestamp":1793923006343,"version":"4.8.0"},"reference-count":60,"publisher":"American Academy of Implant Dentistry","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>Socket preservation (SP) with bone grafting is often used to maintain alveolar ridge dimensions following tooth extraction. However, healing in compromised patients, such as tobacco smokers and patients with type 2 diabetes mellitus (DM), is compromised. Oxygen-releasing hydrogels have emerged as potential adjuncts to enhance osseous healing by improving angiogenesis and osteogenesis. This case report presents 6-month follow-up clinical results of SP using an oxygen-releasing hydrogel dressing in a male smoker with type 2 DM. A 51-year-old male habitual cigarette smoker with a history of type-2 DM presented for the replacement of a grossly carious left maxillary second premolar. Following atraumatic extraction, the socket was irrigated with an oxygen-enriched solution and treated with a topical oxygen-releasing gel before bone grafting with a corticocancellous allograft mixed with the gel. The site was sutured with resorbable sutures, and the healing process was monitored at 2 weeks and 6 months. Clinical and radiographic evaluations were conducted to assess bone regeneration before implant placement. Healing was uneventful, and at the 6-month follow-up, a bone-level dental implant was successfully placed with adequate primary stability. The application of a topical oxygen-rich gel during SP appears to facilitate osseous healing; however, further power-adjusted, long-term randomized controlled trials and histologic investigations are needed to confirm this relationship.<\/jats:p>","DOI":"10.1563\/aaid-joi-d-25-00121","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:30:57Z","timestamp":1754008257000},"page":"500-505","source":"Crossref","is-referenced-by-count":3,"title":["Effect of a Topical Oxygen-Releasing Gel on Osseous-Augmentation Following Socket Preservation in a Male Smoker With Type-2 Diabetes Mellitus: A Case Report"],"prefix":"10.1563","volume":"51","author":[{"given":"Hajer A.","family":"Aldulaijan","sequence":"first","affiliation":[{"name":"Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11433, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haya","family":"Alayadi","sequence":"additional","affiliation":[{"name":"Dental Health Department, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arwa Ameen","family":"Talakey","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11433, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayan B.","family":"Alkurdi","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11433, Saudi Arabia"},{"name":"Department of Dentistry, Riyadh Third Health Cluster, Ministry of Health, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa Y.","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11433, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"434","reference":[{"key":"i1548-1336-51-6-500-b01","series-title":"J Clin Periodontol","first-page":"212","article-title":"Dimensional ridge alterations following tooth extraction. An experimental study in the dog","volume":"32","author":"Ara\u00fajo","year":"2005","unstructured":"Ara\u00fajo MG,\nLindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005;32:212\u2013218."},{"issue":"suppl 21","key":"i1548-1336-51-6-500-b02","series-title":"J Clin Periodontol","first-page":"195","article-title":"Effect of alveolar ridge preservation interventions following tooth extraction: a systematic review and meta-analysis","volume":"46","author":"Avila-Ortiz","year":"2019","unstructured":"Avila-Ortiz G,\nChambrone L,\nVignoletti F. Effect of alveolar ridge preservation interventions following tooth extraction: a systematic review and meta-analysis. J Clin Periodontol. 2019;46(suppl 21):195\u2013223."},{"key":"i1548-1336-51-6-500-b03","series-title":"Dermatol Surg","first-page":"1159","article-title":"The role of oxygen in wound healing: a review of the literature","volume":"34","author":"Rodriguez","year":"2008","unstructured":"Rodriguez PG,\nFelix FN,\nWoodley DT,\nShim EK. The role of oxygen in wound healing: a review of the literature. Dermatol Surg. 2008;34:1159\u20131169."},{"key":"i1548-1336-51-6-500-b04","series-title":"J Clin Periodontol","first-page":"222","article-title":"Periodontal wound healing responses to varying oxygen concentrations and atmospheric pressures","volume":"15","author":"Shannon","year":"1988","unstructured":"Shannon MD,\nHallmon WW,\nMills MP,\nLane JJ,\nNewell DH. Periodontal wound healing responses to varying oxygen concentrations and atmospheric pressures. J Clin Periodontol. 1988;15:222\u2013226."},{"key":"i1548-1336-51-6-500-b05","series-title":"Bioengineering (Basel)","article-title":"A narrative review on means to promote oxygenation and angiogenesis in oral wound healing","volume":"9","author":"Ngeow","year":"2022","unstructured":"Ngeow WC,\nTan CC,\nGoh YC,\nDeliberador TM,\nCheah CW. A narrative review on means to promote oxygenation and angiogenesis in oral wound healing. Bioengineering (Basel). 2022;9."},{"key":"i1548-1336-51-6-500-b06","series-title":"Medicina (Kaunas)","article-title":"The impact of a topical oxygen-releasing gel (blue(\u00ae)m) on deep periodontal pockets: a case report","volume":"60","author":"Alayadi","year":"2024","unstructured":"Alayadi H,\nTalakey A,\nAldulaijan H,\nShaheen MY. The impact of a topical oxygen-releasing gel (blue(\u00ae)m) on deep periodontal pockets: a case report. Medicina (Kaunas). 2024;60."},{"key":"i1548-1336-51-6-500-b07","series-title":"Clin Exp Dent Res","first-page":"376","article-title":"The impact of vaping on periodontitis: a systematic review","volume":"7","author":"Figueredo","year":"2021","unstructured":"Figueredo CA,\nAbdelhay N,\nFigueredo CM,\nCatunda R,\nGibson MP. The impact of vaping on periodontitis: a systematic review. Clin Exp Dent Res. 2021;7:376\u2013384."},{"key":"i1548-1336-51-6-500-b08","series-title":"BMC Oral Health","first-page":"60","article-title":"The impact of smoking on periodontitis patients\u2019 GCF\/serum cytokine profile both before and after periodontal therapy: a meta-analysis","volume":"23","author":"Hao","year":"2023","unstructured":"Hao CP,\nCao NJ,\nZhu YH,\nWang W. The impact of smoking on periodontitis patients\u2019 GCF\/serum cytokine profile both before and after periodontal therapy: a meta-analysis. BMC Oral Health. 2023;23:60."},{"key":"i1548-1336-51-6-500-b09","series-title":"Am J Med","first-page":"22s","article-title":"Smoking and wound healing","volume":"93","author":"Silverstein","year":"1992","unstructured":"Silverstein P. Smoking and wound healing. Am J Med. 1992;93:22s\u201324s."},{"key":"i1548-1336-51-6-500-b10","series-title":"Odontology","first-page":"1","article-title":"Tobacco smoking and chronic destructive periodontal disease","volume":"92","author":"Bergstr\u00f6m","year":"2004","unstructured":"Bergstr\u00f6m J. Tobacco smoking and chronic destructive periodontal disease. Odontology. 2004;92:1\u20138."},{"key":"i1548-1336-51-6-500-b11","series-title":"Tob Induc Dis","article-title":"Cigarette smoke and nicotine effect on human mesenchymal stromal cell wound healing and osteogenic differentiation capacity","volume":"22","author":"Heikkinen","year":"2024","unstructured":"Heikkinen J,\nTanner T,\nBergmann U,\nPalosaari S,\nLehenkari P. Cigarette smoke and nicotine effect on human mesenchymal stromal cell wound healing and osteogenic differentiation capacity. Tob Induc Dis. 2024;22."},{"key":"i1548-1336-51-6-500-b12","series-title":"Crit Rev Oral Biol Med","first-page":"356","article-title":"Smoking and periodontal disease","volume":"11","author":"Kinane","year":"2000","unstructured":"Kinane DF,\nChestnutt IG. Smoking and periodontal disease. Crit Rev Oral Biol Med. 2000;11:356\u2013365."},{"key":"i1548-1336-51-6-500-b13","series-title":"Periodontol 2000","first-page":"50","article-title":"Smoking and periodontal disease","volume":"32","author":"Rivera-Hidalgo","year":"2003","unstructured":"Rivera-Hidalgo F. Smoking and periodontal disease. Periodontol 2000. 2003;32:50\u201358."},{"key":"i1548-1336-51-6-500-b14","series-title":"Clin Calcium","first-page":"1445","article-title":"Smoking & Bone","volume":"26","author":"Watanabe","year":"2016","unstructured":"Watanabe R,\nInoue D. Smoking & Bone. Clin Calcium. 2016;26:1445\u20131450."},{"key":"i1548-1336-51-6-500-b15","series-title":"Int J Immunopathol Pharmacol","first-page":"21","article-title":"Impact of smoking on guided tissue regeneration using a biocomposite poly (lactic-co-glycolic) acid\/sub-micron size hydroxyapatite with a rubber dam as an alternative barrier","volume":"28","author":"Stramazzotti","year":"2015","unstructured":"Stramazzotti D,\nCoiana C,\nZizzi A, et al. Impact of smoking on guided tissue regeneration using a biocomposite poly (lactic-co-glycolic) acid\/sub-micron size hydroxyapatite with a rubber dam as an alternative barrier. Int J Immunopathol Pharmacol. 2015;28:21\u201328."},{"key":"i1548-1336-51-6-500-b16","series-title":"J Clin Invest","first-page":"1219","article-title":"Cellular and molecular basis of wound healing in diabetes","volume":"117","author":"Brem","year":"2007","unstructured":"Brem H,\nTomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest. 2007;117:1219\u20131222."},{"key":"i1548-1336-51-6-500-b17","series-title":"J Dent Res","first-page":"15","article-title":"Diabetes-enhanced inflammation and apoptosis\u2013impact on periodontal pathology","volume":"85","author":"Graves","year":"2006","unstructured":"Graves DT,\nLiu R,\nAlikhani M,\nAl-Mashat H,\nTrackman PC. Diabetes-enhanced inflammation and apoptosis\u2013impact on periodontal pathology. J Dent Res. 2006;85:15\u201321."},{"key":"i1548-1336-51-6-500-b18","series-title":"J Dent Sci","first-page":"268","article-title":"Quercetin ameliorates advanced glycation end product-induced wound healing impairment and inflammaging in human gingival fibroblasts","volume":"19","author":"Huang","year":"2024","unstructured":"Huang CY,\nNg MY,\nLin T, et al. Quercetin ameliorates advanced glycation end product-induced wound healing impairment and inflammaging in human gingival fibroblasts. J Dent Sci. 2024;19:268\u2013275."},{"key":"i1548-1336-51-6-500-b19","series-title":"J Wound Care","first-page":"S4","article-title":"Role of oxygen in wound healing","volume":"29","author":"Younis","year":"2020","unstructured":"Younis I. Role of oxygen in wound healing. J Wound Care. 2020;29:S4\u2013s10."},{"key":"i1548-1336-51-6-500-b20","series-title":"BMC Oral Health","first-page":"242","article-title":"Does smoking cessation affect postoperative healing following oral surgery among smokers?\u2014a systematic review","volume":"24","author":"Olsson","year":"2024","unstructured":"Olsson M,\nNordendahl E,\nKlinge B, et al. Does smoking cessation affect postoperative healing following oral surgery among smokers?\u2014a systematic review. BMC Oral Health. 2024;24:242."},{"key":"i1548-1336-51-6-500-b21","series-title":"Antioxidants (Basel)","article-title":"Flavored and nicotine-containing e-cigarettes induce impaired angiogenesis and diabetic wound healing via increased endothelial oxidative stress and reduced NO bioavailability","volume":"11","author":"Liu","year":"2022","unstructured":"Liu Z,\nZhang Y,\nYoun JY, et al. Flavored and nicotine-containing e-cigarettes induce impaired angiogenesis and diabetic wound healing via increased endothelial oxidative stress and reduced NO bioavailability. Antioxidants (Basel). 2022;11."},{"key":"i1548-1336-51-6-500-b22","series-title":"Curr Diabetes Rev","first-page":"355","article-title":"Advanced glycation end products: a link between periodontitis and diabetes mellitus","volume":"9","author":"Gurav","year":"2013","unstructured":"Gurav AN. Advanced glycation end products: a link between periodontitis and diabetes mellitus? Curr Diabetes Rev. 2013;9:355\u2013361."},{"key":"i1548-1336-51-6-500-b23","series-title":"Nat Rev Endocrinol","first-page":"738","article-title":"Diabetes mellitus and periodontitis: a tale of two common interrelated diseases","volume":"7","author":"Lalla","year":"2011","unstructured":"Lalla E,\nPapapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol. 2011;7:738\u2013748."},{"key":"i1548-1336-51-6-500-b24","series-title":"J Clin Periodontol","first-page":"138","article-title":"Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology","volume":"45","author":"Sanz","year":"2018","unstructured":"Sanz M,\nCeriello A,\nBuysschaert M, et al. Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. J Clin Periodontol. 2018;45:138\u2013149."},{"key":"i1548-1336-51-6-500-b25","series-title":"J Periodontol","first-page":"440","article-title":"Advanced glycation end products upregulate the endoplasmic reticulum stress in human periodontal ligament cells","volume":"86","author":"Xu","year":"2015","unstructured":"Xu J,\nXiong M,\nHuang B,\nChen H. Advanced glycation end products upregulate the endoplasmic reticulum stress in human periodontal ligament cells. J Periodontol. 2015;86:440\u2013447."},{"key":"i1548-1336-51-6-500-b26","series-title":"Periodontol 2000","first-page":"214","article-title":"The impact of diabetes on periodontal diseases","volume":"82","author":"Graves","year":"2020","unstructured":"Graves DT,\nDing Z,\nYang Y. The impact of diabetes on periodontal diseases. Periodontol 2000. 2020;82:214\u2013224."},{"key":"i1548-1336-51-6-500-b27","series-title":"J Periodontal Res","first-page":"334","article-title":"Advanced glycation end-products increase IL-6 and ICAM-1 expression via RAGE, MAPK and NF-\u03baB pathways in human gingival fibroblasts","volume":"53","author":"Nonaka","year":"2018","unstructured":"Nonaka K,\nKajiura Y,\nBando M, et al. Advanced glycation end-products increase IL-6 and ICAM-1 expression via RAGE, MAPK and NF-\u03baB pathways in human gingival fibroblasts. J Periodontal Res. 2018;53:334\u2013344."},{"key":"i1548-1336-51-6-500-b28","series-title":"Healthcare (Basel)","article-title":"Glycemic control and implant stability in patients with type II diabetes: narrative review","volume":"13","author":"Cosola","year":"2025","unstructured":"Cosola S,\nButera A,\nHailu Zergaw A, et al. Glycemic control and implant stability in patients with type II diabetes: narrative review. Healthcare (Basel). 2025;13."},{"key":"i1548-1336-51-6-500-b29","series-title":"Curr Diabetes Rev","first-page":"e060821195367","article-title":"Should the quality of glycemic control guide dental implant therapy in patients with diabetes? Focus on implant survival","volume":"18","author":"Nourah","year":"2022","unstructured":"Nourah D,\nAldahlawi S,\nAndreana S. Should the quality of glycemic control guide dental implant therapy in patients with diabetes? Focus on implant survival. Curr Diabetes Rev. 2022;18:e060821195367."},{"key":"i1548-1336-51-6-500-b30","series-title":"Braz Oral Res","first-page":"e074","article-title":"The impact of maintenance on peri-implant health","volume":"33","author":"R\u00f6sing","year":"2019","unstructured":"R\u00f6sing CK,\nFiorini T,\nHaas AN,\nMuniz F,\nOppermann RV,\nSusin C. The impact of maintenance on peri-implant health. Braz Oral Res. 2019;33:e074."},{"key":"i1548-1336-51-6-500-b01","series-title":"J Clin Periodontol","first-page":"212","article-title":"Dimensional ridge alterations following tooth extraction. An experimental study in the dog","volume":"32","author":"Ara\u00fajo","year":"2005","unstructured":"Ara\u00fajo MG,\nLindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005;32:212\u2013218."},{"issue":"suppl 21","key":"i1548-1336-51-6-500-b02","series-title":"J Clin Periodontol","first-page":"195","article-title":"Effect of alveolar ridge preservation interventions following tooth extraction: a systematic review and meta-analysis","volume":"46","author":"Avila-Ortiz","year":"2019","unstructured":"Avila-Ortiz G,\nChambrone L,\nVignoletti F. Effect of alveolar ridge preservation interventions following tooth extraction: a systematic review and meta-analysis. J Clin Periodontol. 2019;46(suppl 21):195\u2013223."},{"key":"i1548-1336-51-6-500-b03","series-title":"Dermatol Surg","first-page":"1159","article-title":"The role of oxygen in wound healing: a review of the literature","volume":"34","author":"Rodriguez","year":"2008","unstructured":"Rodriguez PG,\nFelix FN,\nWoodley DT,\nShim EK. The role of oxygen in wound healing: a review of the literature. Dermatol Surg. 2008;34:1159\u20131169."},{"key":"i1548-1336-51-6-500-b04","series-title":"J Clin Periodontol","first-page":"222","article-title":"Periodontal wound healing responses to varying oxygen concentrations and atmospheric pressures","volume":"15","author":"Shannon","year":"1988","unstructured":"Shannon MD,\nHallmon WW,\nMills MP,\nLane JJ,\nNewell DH. Periodontal wound healing responses to varying oxygen concentrations and atmospheric pressures. J Clin Periodontol. 1988;15:222\u2013226."},{"key":"i1548-1336-51-6-500-b05","series-title":"Bioengineering (Basel)","article-title":"A narrative review on means to promote oxygenation and angiogenesis in oral wound healing","volume":"9","author":"Ngeow","year":"2022","unstructured":"Ngeow WC,\nTan CC,\nGoh YC,\nDeliberador TM,\nCheah CW. A narrative review on means to promote oxygenation and angiogenesis in oral wound healing. Bioengineering (Basel). 2022;9."},{"key":"i1548-1336-51-6-500-b06","series-title":"Medicina (Kaunas)","article-title":"The impact of a topical oxygen-releasing gel (blue(\u00ae)m) on deep periodontal pockets: a case report","volume":"60","author":"Alayadi","year":"2024","unstructured":"Alayadi H,\nTalakey A,\nAldulaijan H,\nShaheen MY. The impact of a topical oxygen-releasing gel (blue(\u00ae)m) on deep periodontal pockets: a case report. Medicina (Kaunas). 2024;60."},{"key":"i1548-1336-51-6-500-b07","series-title":"Clin Exp Dent Res","first-page":"376","article-title":"The impact of vaping on periodontitis: a systematic review","volume":"7","author":"Figueredo","year":"2021","unstructured":"Figueredo CA,\nAbdelhay N,\nFigueredo CM,\nCatunda R,\nGibson MP. The impact of vaping on periodontitis: a systematic review. Clin Exp Dent Res. 2021;7:376\u2013384."},{"key":"i1548-1336-51-6-500-b08","series-title":"BMC Oral Health","first-page":"60","article-title":"The impact of smoking on periodontitis patients\u2019 GCF\/serum cytokine profile both before and after periodontal therapy: a meta-analysis","volume":"23","author":"Hao","year":"2023","unstructured":"Hao CP,\nCao NJ,\nZhu YH,\nWang W. The impact of smoking on periodontitis patients\u2019 GCF\/serum cytokine profile both before and after periodontal therapy: a meta-analysis. BMC Oral Health. 2023;23:60."},{"key":"i1548-1336-51-6-500-b09","series-title":"Am J Med","first-page":"22s","article-title":"Smoking and wound healing","volume":"93","author":"Silverstein","year":"1992","unstructured":"Silverstein P. Smoking and wound healing. Am J Med. 1992;93:22s\u201324s."},{"key":"i1548-1336-51-6-500-b10","series-title":"Odontology","first-page":"1","article-title":"Tobacco smoking and chronic destructive periodontal disease","volume":"92","author":"Bergstr\u00f6m","year":"2004","unstructured":"Bergstr\u00f6m J. Tobacco smoking and chronic destructive periodontal disease. Odontology. 2004;92:1\u20138."},{"key":"i1548-1336-51-6-500-b11","series-title":"Tob Induc Dis","article-title":"Cigarette smoke and nicotine effect on human mesenchymal stromal cell wound healing and osteogenic differentiation capacity","volume":"22","author":"Heikkinen","year":"2024","unstructured":"Heikkinen J,\nTanner T,\nBergmann U,\nPalosaari S,\nLehenkari P. Cigarette smoke and nicotine effect on human mesenchymal stromal cell wound healing and osteogenic differentiation capacity. Tob Induc Dis. 2024;22."},{"key":"i1548-1336-51-6-500-b12","series-title":"Crit Rev Oral Biol Med","first-page":"356","article-title":"Smoking and periodontal disease","volume":"11","author":"Kinane","year":"2000","unstructured":"Kinane DF,\nChestnutt IG. Smoking and periodontal disease. Crit Rev Oral Biol Med. 2000;11:356\u2013365."},{"key":"i1548-1336-51-6-500-b13","series-title":"Periodontol 2000","first-page":"50","article-title":"Smoking and periodontal disease","volume":"32","author":"Rivera-Hidalgo","year":"2003","unstructured":"Rivera-Hidalgo F. Smoking and periodontal disease. Periodontol 2000. 2003;32:50\u201358."},{"key":"i1548-1336-51-6-500-b14","series-title":"Clin Calcium","first-page":"1445","article-title":"Smoking & Bone","volume":"26","author":"Watanabe","year":"2016","unstructured":"Watanabe R,\nInoue D. Smoking & Bone. Clin Calcium. 2016;26:1445\u20131450."},{"key":"i1548-1336-51-6-500-b15","series-title":"Int J Immunopathol Pharmacol","first-page":"21","article-title":"Impact of smoking on guided tissue regeneration using a biocomposite poly (lactic-co-glycolic) acid\/sub-micron size hydroxyapatite with a rubber dam as an alternative barrier","volume":"28","author":"Stramazzotti","year":"2015","unstructured":"Stramazzotti D,\nCoiana C,\nZizzi A, et al. Impact of smoking on guided tissue regeneration using a biocomposite poly (lactic-co-glycolic) acid\/sub-micron size hydroxyapatite with a rubber dam as an alternative barrier. Int J Immunopathol Pharmacol. 2015;28:21\u201328."},{"key":"i1548-1336-51-6-500-b16","series-title":"J Clin Invest","first-page":"1219","article-title":"Cellular and molecular basis of wound healing in diabetes","volume":"117","author":"Brem","year":"2007","unstructured":"Brem H,\nTomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest. 2007;117:1219\u20131222."},{"key":"i1548-1336-51-6-500-b17","series-title":"J Dent Res","first-page":"15","article-title":"Diabetes-enhanced inflammation and apoptosis\u2013impact on periodontal pathology","volume":"85","author":"Graves","year":"2006","unstructured":"Graves DT,\nLiu R,\nAlikhani M,\nAl-Mashat H,\nTrackman PC. Diabetes-enhanced inflammation and apoptosis\u2013impact on periodontal pathology. J Dent Res. 2006;85:15\u201321."},{"key":"i1548-1336-51-6-500-b18","series-title":"J Dent Sci","first-page":"268","article-title":"Quercetin ameliorates advanced glycation end product-induced wound healing impairment and inflammaging in human gingival fibroblasts","volume":"19","author":"Huang","year":"2024","unstructured":"Huang CY,\nNg MY,\nLin T, et al. Quercetin ameliorates advanced glycation end product-induced wound healing impairment and inflammaging in human gingival fibroblasts. J Dent Sci. 2024;19:268\u2013275."},{"key":"i1548-1336-51-6-500-b19","series-title":"J Wound Care","first-page":"S4","article-title":"Role of oxygen in wound healing","volume":"29","author":"Younis","year":"2020","unstructured":"Younis I. Role of oxygen in wound healing. J Wound Care. 2020;29:S4\u2013s10."},{"key":"i1548-1336-51-6-500-b20","series-title":"BMC Oral Health","first-page":"242","article-title":"Does smoking cessation affect postoperative healing following oral surgery among smokers?\u2014a systematic review","volume":"24","author":"Olsson","year":"2024","unstructured":"Olsson M,\nNordendahl E,\nKlinge B, et al. Does smoking cessation affect postoperative healing following oral surgery among smokers?\u2014a systematic review. BMC Oral Health. 2024;24:242."},{"key":"i1548-1336-51-6-500-b21","series-title":"Antioxidants (Basel)","article-title":"Flavored and nicotine-containing e-cigarettes induce impaired angiogenesis and diabetic wound healing via increased endothelial oxidative stress and reduced NO bioavailability","volume":"11","author":"Liu","year":"2022","unstructured":"Liu Z,\nZhang Y,\nYoun JY, et al. Flavored and nicotine-containing e-cigarettes induce impaired angiogenesis and diabetic wound healing via increased endothelial oxidative stress and reduced NO bioavailability. Antioxidants (Basel). 2022;11."},{"key":"i1548-1336-51-6-500-b22","series-title":"Curr Diabetes Rev","first-page":"355","article-title":"Advanced glycation end products: a link between periodontitis and diabetes mellitus","volume":"9","author":"Gurav","year":"2013","unstructured":"Gurav AN. Advanced glycation end products: a link between periodontitis and diabetes mellitus? Curr Diabetes Rev. 2013;9:355\u2013361."},{"key":"i1548-1336-51-6-500-b23","series-title":"Nat Rev Endocrinol","first-page":"738","article-title":"Diabetes mellitus and periodontitis: a tale of two common interrelated diseases","volume":"7","author":"Lalla","year":"2011","unstructured":"Lalla E,\nPapapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol. 2011;7:738\u2013748."},{"key":"i1548-1336-51-6-500-b24","series-title":"J Clin Periodontol","first-page":"138","article-title":"Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology","volume":"45","author":"Sanz","year":"2018","unstructured":"Sanz M,\nCeriello A,\nBuysschaert M, et al. Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. J Clin Periodontol. 2018;45:138\u2013149."},{"key":"i1548-1336-51-6-500-b25","series-title":"J Periodontol","first-page":"440","article-title":"Advanced glycation end products upregulate the endoplasmic reticulum stress in human periodontal ligament cells","volume":"86","author":"Xu","year":"2015","unstructured":"Xu J,\nXiong M,\nHuang B,\nChen H. Advanced glycation end products upregulate the endoplasmic reticulum stress in human periodontal ligament cells. J Periodontol. 2015;86:440\u2013447."},{"key":"i1548-1336-51-6-500-b26","series-title":"Periodontol 2000","first-page":"214","article-title":"The impact of diabetes on periodontal diseases","volume":"82","author":"Graves","year":"2020","unstructured":"Graves DT,\nDing Z,\nYang Y. The impact of diabetes on periodontal diseases. Periodontol 2000. 2020;82:214\u2013224."},{"key":"i1548-1336-51-6-500-b27","series-title":"J Periodontal Res","first-page":"334","article-title":"Advanced glycation end-products increase IL-6 and ICAM-1 expression via RAGE, MAPK and NF-\u03baB pathways in human gingival fibroblasts","volume":"53","author":"Nonaka","year":"2018","unstructured":"Nonaka K,\nKajiura Y,\nBando M, et al. Advanced glycation end-products increase IL-6 and ICAM-1 expression via RAGE, MAPK and NF-\u03baB pathways in human gingival fibroblasts. J Periodontal Res. 2018;53:334\u2013344."},{"key":"i1548-1336-51-6-500-b28","series-title":"Healthcare (Basel)","article-title":"Glycemic control and implant stability in patients with type II diabetes: narrative review","volume":"13","author":"Cosola","year":"2025","unstructured":"Cosola S,\nButera A,\nHailu Zergaw A, et al. Glycemic control and implant stability in patients with type II diabetes: narrative review. Healthcare (Basel). 2025;13."},{"key":"i1548-1336-51-6-500-b29","series-title":"Curr Diabetes Rev","first-page":"e060821195367","article-title":"Should the quality of glycemic control guide dental implant therapy in patients with diabetes? Focus on implant survival","volume":"18","author":"Nourah","year":"2022","unstructured":"Nourah D,\nAldahlawi S,\nAndreana S. Should the quality of glycemic control guide dental implant therapy in patients with diabetes? Focus on implant survival. Curr Diabetes Rev. 2022;18:e060821195367."},{"key":"i1548-1336-51-6-500-b30","series-title":"Braz Oral Res","first-page":"e074","article-title":"The impact of maintenance on peri-implant health","volume":"33","author":"R\u00f6sing","year":"2019","unstructured":"R\u00f6sing CK,\nFiorini T,\nHaas AN,\nMuniz F,\nOppermann RV,\nSusin C. The impact of maintenance on peri-implant health. Braz Oral Res. 2019;33:e074."}],"container-title":["Journal of Oral Implantology"],"original-title":[],"link":[{"URL":"https:\/\/joi.kglmeridian.com\/view\/journals\/orim\/51\/6\/article-p500.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joi.kglmeridian.com\/downloadpdf\/journals\/orim\/51\/6\/article-p500.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/joi.kglmeridian.com\/downloadpdf\/journals\/orim\/51\/6\/article-p500.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:52:04Z","timestamp":1770771124000},"score":1,"resource":{"primary":{"URL":"https:\/\/joi.kglmeridian.com\/view\/journals\/orim\/51\/6\/article-p500.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":60,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1563\/aaid-joi-d-25-00121","relation":{},"ISSN":["1548-1336","0160-6972"],"issn-type":[{"value":"1548-1336","type":"electronic"},{"value":"0160-6972","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]}}}