{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T21:08:00Z","timestamp":1778533680306,"version":"3.51.4"},"reference-count":0,"publisher":"Universidad de Santander - UDES","issue":"3","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["udes.edu.co"],"crossmark-restriction":true},"short-container-title":["Rev Cuid"],"published-print":{"date-parts":[[2025,12,17]]},"abstract":"El uso intensivo de macr\u00f3lidos, como la azitromicina, durante la pandemia de COVID-19 ha favorecido el desarrollo de resistencia antimicrobiana en bacterias Grampositivas a trav\u00e9s de m\u00faltiples mecanismos de resistencia, como la modificaci\u00f3n del ARN ribosomal, bombas de expulsi\u00f3n e inactivaci\u00f3n enzim\u00e1tica. Objetivo: Describir la prevalencia de genes de resistencia en bacterias aisladas de pacientes con COVID-19 en Santander, Colombia. Materiales y M\u00e9todos: Se realiz\u00f3 un estudio descriptivo de 112 muestras almacenadas de hisopados nasofar\u00edngeos, orofar\u00edngeos y aspirados traqueales de pacientes hospitalizados con COVID-19 en 2020, de las cuales se aislaron 48 cepas Grampositivas. La resistencia a macr\u00f3lidos y la presencia de los genes ermA, ermB, ermT y mef(A\/E) se evaluaron mediante pruebas fenot\u00edpicas y moleculares. Resultados:Staphylococcus aureus fue la especie m\u00e1s prevalente con un 58,33% (28), seguida de Staphylococcus epidermidis con un 31,25% (15). Un 47,92% (23) de las cepas mostr\u00f3 resistencia fenot\u00edpica a la azitromicina, y un 81,25% (39) resistencia genot\u00edpica, con predominancia de ermB con el 58,33% (28) y ermT con el 45,83% (22), sin detecci\u00f3n de mef(A\/E). Discusi\u00f3n: Estos hallazgos muestran una alta prevalencia de resistencia a macr\u00f3lidos, lo cual puede estar relacionado con el uso extensivo de estos antibi\u00f3ticos durante la pandemia. Conclusiones: El aumento en la resistencia a macr\u00f3lidos en bacterias Grampositivas representa un reto cr\u00edtico para la salud p\u00fablica, especialmente en el contexto de pandemias. Estos resultados subrayan la necesidad urgente de implementar medidas de control en el uso de antibi\u00f3ticos.<\/jats:p>","DOI":"10.15649\/cuidarte.4924","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T22:20:42Z","timestamp":1766010042000},"update-policy":"https:\/\/doi.org\/10.15649\/cuidarte.crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Resistencia a macr\u00f3lidos en Staphylococcus de pacientes con COVID-19 en Santander"],"prefix":"10.15649","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2639-1085","authenticated-orcid":false,"given":"Michael J.","family":"Santos-Angarita","sequence":"first","affiliation":[{"name":"Universidad de Santander, Facultad de Ciencias M\u00e9dicas y de la Salud, Instituto de Investigaciones MASIRA. Bucaramanga, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8819-8175","authenticated-orcid":false,"given":"Monica Y.","family":"Arias Guerrero","sequence":"additional","affiliation":[{"name":"Universidad de Santander, Facultad de Ciencias M\u00e9dicas y de la Salud, Instituto de Investigaciones MASIRA. Bucaramanga, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9203-1706","authenticated-orcid":false,"given":"Andrea J.","family":"Parada-Diaz","sequence":"additional","affiliation":[{"name":"Universidad de Santander, Facultad de Ciencias M\u00e9dicas y de la Salud, Instituto de Investigaciones MASIRA. Bucaramanga, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2049-500X","authenticated-orcid":false,"given":"Natalia A.","family":"Bravo Granados","sequence":"additional","affiliation":[{"name":"Universidad de Santander, Colecci\u00f3n Biol\u00f3gica CBUDES. Bucaramanga, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6388-5796","authenticated-orcid":false,"given":"Nadia C. Alfonso Vargas","family":"Alfonso Vargas","sequence":"additional","affiliation":[{"name":"Universidad de Boyac\u00e1, Facultad Ciencias de la Salud. Programa de Bacteriolog\u00eda y Laboratorio Cl\u00ednico. Tunja, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0697-3386","authenticated-orcid":false,"given":"Juanita Trejos-Su\u00e1rez","family":"Trejos-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Universidad de Santander, Facultad de Ciencias M\u00e9dicas y de la Salud, Instituto de Investigaciones MASIRA. Bucaramanga, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6285","published-online":{"date-parts":[[2025,12,17]]},"container-title":["Revista Cuidarte"],"original-title":["Macrolide resistance in Staphylococcus from COVID-19 patients in Santander"],"link":[{"URL":"https:\/\/revistas.udes.edu.co\/cuidarte\/article\/download\/4924\/3599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.udes.edu.co\/cuidarte\/article\/download\/4924\/3600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.udes.edu.co\/cuidarte\/article\/download\/4924\/3610","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.udes.edu.co\/cuidarte\/article\/download\/4924\/3611","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.udes.edu.co\/cuidarte\/article\/download\/4924\/3599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T20:14:57Z","timestamp":1778530497000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistas.udes.edu.co\/cuidarte\/article\/view\/4924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,12,17]]},"published-print":{"date-parts":[[2025,12,17]]}},"URL":"https:\/\/doi.org\/10.15649\/cuidarte.4924","relation":{},"ISSN":["2216-0973","2346-3414"],"issn-type":[{"value":"2216-0973","type":"print"},{"value":"2346-3414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]}}}