{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:20:34Z","timestamp":1789914034452,"version":"4.0.1"},"reference-count":52,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Erkrankungen von Milchk\u00fchen im peripartalen Zeitraum gelten als entscheidende Faktoren f\u00fcr eine Beeintr\u00e4chtigung der Milchleistung und sind mittlerweile ein zentraler Aspekt der Herdendiagnostik. In den letzten 40 Jahren wurden anhand von Blutproben erstellte metabolische Profile zur Herdendiagnostik genutzt, wobei die Erfahrungen bez\u00fcglich der diagnostischen Wertigkeit differierten. Die Forschung f\u00fchrte zu umfangreichen Erkenntnissen dar\u00fcber, wie physiologische Mechanismen bei der Kuh, das Management, die Umwelt sowie Interaktionen zwischen diesen Faktoren zur Entwicklung von Erkrankungen im peripartalen Zeitraum beitragen. K\u00fche mit hohem Risiko f\u00fcr eine erforderlich werdende Behandlung lassen sich anhand einer erh\u00f6hten Konzentration an \u03b2-Hydroxybutyrat (BHB) (&gt; 1,2 mmol\/l) in den ersten 7\u201310 Tagen nach dem Kalben identifizieren. Ergeben Herdenkontrollen bei 15\u201320% der Frischabkalber in der ersten Woche post partum erh\u00f6hte BHB-Konzentrationen, weist dies auf ein betr\u00e4chtliches Krankheitsrisiko und Produktionsverluste hin. Auch eine erh\u00f6hte Serumkonzentration freier Fetts\u00e4uren (FFS) ist Hinweis f\u00fcr ein gesteigertes Krankheitsrisiko. In dieser \u00dcbersicht werden gesicherte (BHB, FFS) und weitere potenzielle Parameter erl\u00e4utert, die sich, bei Untersuchung von Einzel- oder Poolproben, dazu eignen, das Risiko f\u00fcr Erkrankungen und den Ern\u00e4hrungszustand der Tiere einzusch\u00e4tzen. Ihre Anwendung in Form metabolischer Profile zur Herdendiagnostik bei bestehenden Risiken oder im Rahmen der Herden\u00fcberwachung wird dargestellt. Eine Poolprobe nach dem modifizierten \u201eCompton Metabolic Profile\u201c erm\u00f6glicht die wirtschaftlichere Nutzung mehrerer Parameter, wenngleich diese Vorgehensweise die Interpreta - tion und die Anwendung in Abh\u00e4ngigkeit von der Herdengr\u00f6\u00dfe einschr\u00e4nken kann. Poolproben von f\u00fcnf bis zehn Individuen repr\u00e4sentieren genau das arithmetische Mittel aus den Werten der einzelnen Tiere. Von gr\u00f6\u00dfter Bedeutung ist, dass die metabolischen Profile im Zusammenhang mit anderen diagnostischen Kennzahlen von Tier- und Betriebsanalysen, der K\u00f6rperkonditionsbeurteilung und der Rationskontrolle genutzt werden. Nur so l\u00e4sst sich ihr Wert im Rahmen der Herdenunter - suchung voll aussch\u00f6pfen.<\/jats:p>","DOI":"10.15653\/tpg-150947","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T07:34:27Z","timestamp":1459409667000},"page":"118-126","source":"Crossref","is-referenced-by-count":16,"title":["Indikatoren f\u00fcr Risiken bei K\u00fchen in der Transitphase \u2013 eine \u00dcbersicht zu metabolischen Profilen"],"prefix":"10.15653","volume":"44","author":[{"given":"R. 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