{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:12:02Z","timestamp":1775016722590,"version":"3.50.1"},"reference-count":62,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Systematische Stoffwechsel\u00fcberwachung begann im deutschsprachigen Raum Ende der 1960er, Anfang der 1970er Jahre wegen der Zunahme von Stoffwechselst\u00f6rungen als Ursache f\u00fcr Infertilit\u00e4t und Mastitiden und hatte das Ziel besserer Prophylaxe durch deren Fr\u00fch diagnostik. Entwicklung eines einheitlichen Stoffwechselstandards: Initiiert von Rossow, G\u00fcrtler, Ehrentraut, Seidel und Furcht wurde in den 1970er Jahren ein Standard \u201eStoffwechsel\u00fcberwachung in der Rinderproduktion\u201d erarbeitet, der auf Betriebsanalyse, klinischen und biochemischen Kontrollen, Prophylaxe und Nachkontrollen basierte. Kernpunkte waren: periodische Screenings stark belasteter, gesunder Indikatortiere 2\u20134 Tage post partum (p. p.), 2\u20138 Wochen p. p. und 1\u20132 Wochen ante partum, maximal 10 Tiere pro Gruppe, Poolproben sind in der Regel sinnvoll, Einzeltierproben optimal, informativstes Probensubstrat und Parameter nutzen, sorgf\u00e4ltiger Umgang mit Proben, sachkundige Auswertung und Nachkontrolle. Bei Stoffwechselkontrollen von 1982 bis 1989 ergaben sich bei ca. 242000 K\u00fchen im Mittel zu 32,9% Ketosen, 20,0% metabolische Azidosen, 21,9% metabolische Alkalosen, 34,2% Stickstoff-Stoffwechselst\u00f6rungen, 17,3% Natriummangel und 23,7% Leberst\u00f6rungen. Weiterentwicklung des Stoffwechselstandards nach 1989: Bearbeitet wurden Referenzwerte bei h\u00f6herer Milchleistung, die Fr\u00fchdiagnose von Krankheiten des Fettmobilisationssyndroms sowie bessere Fr\u00fchdiagnostik durch neue Indikatoren, darunter Kreatinkinase (CK), alkalische Phosphatase (AP) mit Isoenzymen, Akute-Phase-Proteine, Zytokine, Antioxidanzien, Carnitin- und Lipoproteinfraktionen. Optimierte Blut- und Harnscreenings haben gegen\u00fcber Milchanalytik wichtige Vorteile. Sie sind eine wichtige Methode zur Gesundheits- und Leistungsstabilisierung durch exakte Ursachenanalyse und abgeleitete Pr\u00e4vention. Klinische Bedeutung: Als Standardspektrum f\u00fcr Screenings haben sich die fruchtbarkeitsrelevanten Parameter freie Fetts\u00e4uren, \u03b2-Hydroxybutyrat, Harn stoff, anorganisches Phosphat, CK, AP, Natrium, Kalium, Selen, Kupfer, \u03b2-Carotin und Netto-S\u00e4ure- Basen-Ausscheidung bew\u00e4hrt. Sie sollten einmal pro Jahr\/Herde, gegebenenfalls als kosteng\u00fcnstige Poolprobe f\u00fcr ca. 50 \u20ac, untersucht werden.<\/jats:p>","DOI":"10.15653\/tpg-151045","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T15:17:56Z","timestamp":1458573476000},"page":"107-117","source":"Crossref","is-referenced-by-count":6,"title":["Entwicklung und Grundlagen der Stoffwechsel\u00fcberwachung bei Milchk\u00fchen"],"prefix":"10.15653","volume":"44","author":[{"given":"M.","family":"F\u00fcrll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"10.15653\/TPG-151045-1","unstructured":"Baumgartner W. Zur Aussagekraft klinisch-chemischer Laborbefunde in der Krankheitsdiagnostik beim Rind. 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