{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:42:35Z","timestamp":1784130155999,"version":"3.55.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Ziel der Studie war, die H\u00e4ufigkeit der verschiedenen sonographischen Milzver\u00e4nderungen bei den einzelnen anatomischen Formen des kaninen malignen Lymphoms zu ermitteln. Ferner sollte eruiert werden, inwieweit das in der Literatur beim Lymphom beschriebene Mottenfra\u00dfmuster bei Patienten ohne Lymphom auftritt.<\/jats:p><jats:p>Retrospektive Auswertung der Patientendaten von Hunden, bei denen zytologisch oder histologisch ein malignes Lymphom diagnostiziert wurde und eine vor der Therapie erfolgte Ultraschalluntersuchung des Abdomens dokumentiert war. Die Patientendaten von Hunden mit einem Mottenfra\u00dfmuster der Milz unterlagen einer gesonderten Auswertung. Als Ausschlusskriterium galt die Gabe eines Zytostatikums vor der Diagnostik.<\/jats:p><jats:p>Bei 137 (84%) der ermittelten 164 Hunde mit einem malignen Lymphom bestanden sonographische Milzver\u00e4nderungen. Von diesen 137 Tieren zeigten 94 ein Mottenfra\u00dfmuster des Milzparenchyms und 43 Hunde Auff\u00e4lligkeiten in Form von Splenomegalie, grobk\u00f6rniger Echotextur oder sonstiger Parenchymver\u00e4nderungen. Beim Befund des Mottenfra\u00dfmusters lag signifikant h\u00e4ufiger ein multizentrisches Lymphom (95%) als ein Lymphom anderer anatomischer Klassifikation vor. Lediglich ein Hund wies ein Mottenfra\u00dfmuster des Milzparenchyms auf, ohne an einem malignen Lymphom erkrankt zu sein. Damit ergab sich der positive pr\u00e4diktive Wert des Mottenfra\u00dfmusters f\u00fcr das maligne Lymphom mit 99% und speziell f\u00fcr das multizentrische Lymphom mit 95%. Insgesamt hatten 84% der 164 Hunde ein multizentrisches Lymphom, jeweils 5% ein mediastinales bzw. kutanes Lymphom, 4% ein gastrointestinales Lymphom und jeweils ein Tier ein okul\u00e4res bzw. renales Lymphom.<\/jats:p><jats:p>Sonographische Milzver\u00e4nderungen kommen beim malignen Lymphom des Hundes unabh\u00e4ngig von dessen anatomischer Form h\u00e4ufig vor. Bei sonographischem Nachweis eines Mottenfra\u00dfmusters der Milz kann mit sehr hoher Wahrscheinlichkeit davon ausgegangen werden, dass der betroffene Hund an einem malignen Lymphom leidet, wobei es sich \u00fcberwiegend um ein multizentrisches Lymphom handelt.<\/jats:p>","DOI":"10.15654\/tpk-140881","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T10:59:22Z","timestamp":1434452362000},"page":"215-220","source":"Crossref","is-referenced-by-count":2,"title":["Sonographisch erfassbare Milzver\u00e4nderungen bei Hunden mit malignem Lymphom"],"prefix":"10.15654","volume":"43","author":[{"given":"C.","family":"K\u00f6hler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Krastel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Winter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alef","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kiefer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Eberhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"10.15654\/TPK-140881-1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1182\/blood.V63.2.380.380","volume":"63","author":"Bell","year":"1984","journal-title":"Blood"},{"key":"10.15654\/TPK-140881-2","first-page":"291","volume":"7","author":"Couto","year":"1985","journal-title":"Comp Cont Educ Pract Vet"},{"key":"10.15654\/TPK-140881-3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01725.x"},{"key":"10.15654\/TPK-140881-4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2004.04095.x"},{"key":"10.15654\/TPK-140881-5","unstructured":"Day MJ, Dobson JM. 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