{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:03:18Z","timestamp":1777420998896,"version":"3.51.4"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Acht eng verwandte Mitglieder einer Linie von Working Kelpies zeigten Symptome einer Dermatomyositis in Form von Alopezie, Krusten, Ulzerationen der Haut, Depigmentation von Nasenspiegel und Lefzen, Onychodystrophie und Muskelatrophie, vor allem der Kaumuskeln. Die Symptome waren bei den betroffenen Tieren unterschiedlich stark oder nur teilweise ausgepr\u00e4gt. Die klinische Diagnose wurde bei drei Hunden durch histologische Untersuchung von Hautbioptaten, nicht jedoch Muskelbioptaten best\u00e4tigt. Therapeutisch kamen verschiedene immunmodulatorische Medikamente (Steroide, Ciclosporin, Mycophenolat-Mofetil, Pentoxifyllin, Doxycylin\/Niacinamid, Omega-3-Fetts\u00e4uren, Vitamin E) mit unterschiedlichem Erfolg zum Einsatz. Bei der Dermatomyositis handelt es sich um eine immunvermittelte Erkrankung mit genetischem Hintergrund bei Mensch und Hund. Die verantwortlichen Gene sind weitgehend unbekannt. F\u00fcr die Hunderassen Collie und Shetland Sheepdog besteht eine Pr\u00e4disposition. Zudem wird eine famili\u00e4re H\u00e4ufung beim Beauceron beschrieben. Da die Rasse Working Kelpie im 19. Jahrhundert aus schottischen Hunden des Collie-Typs entstanden ist, w\u00e4re eine genetische Pr\u00e4disposition f\u00fcr die Dermatomyositis erkl\u00e4rbar.<\/jats:p>","DOI":"10.15654\/tpk-141112","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T08:24:21Z","timestamp":1435134261000},"page":"331-336","source":"Crossref","is-referenced-by-count":3,"title":["Famili\u00e4res Auftreten der Dermatomyositis bei Working Kelpies"],"prefix":"10.15654","volume":"43","author":[{"given":"S.","family":"R\u00fcfenacht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Welle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Thom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"R\u00f6thig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"10.15654\/TPK-141112-1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-011-0167-9"},{"key":"10.15654\/TPK-141112-2","first-page":"125","volume":"173","author":"Bensignor","year":"1997","journal-title":"Rec Med Vet"},{"key":"10.15654\/TPK-141112-3","unstructured":"Campbell KL, Lowe AD, Lichtensteiger CA. Dermatomyositis in three Portuguese water dog littermates. 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