{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T18:52:29Z","timestamp":1758394349030},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Ein 8 Monate alter, m\u00e4nnlicher Afrikanischer Wei\u00dfbauchigel zeigte klinisch einen schwankenden Gang, Anurie, Inappetenz und Apathie, woraufhin die Verdachtsdiagnose Wobbly Hedgehog Syndrome gestellt wurde. Nach Exazerbation wurde der Igel euthanasiert. Der histologisch im Gro\u00dfhirn nachgewiesene Tumor bestand \u00fcberwiegend aus mittelgro\u00dfen, ovoiden Zellen und einer in geringerer Zahl vorhandenen spindelzelligen Zellpopulation. Im Tumor fanden sich Neuropil-Inseln und extrazellul\u00e4res myxoides Material. Immunhistochemisch exprimierten die Tumorzellen sowohl oligodendrogliale (neuritic outgrowth inhibitor, Nogo-A; oligodendrocyte transcription factor, Olig-2) als auch neuronale (neuronenspezifische Enolase, NSE; microtubuleassociated protein-2a, MAP-2a; Synaptophysin) Zellmarker. Anhand der Befunde wurde die Diagnose eines Oligodendroglioms mit neuronaler Differenzierung gestellt, wobei es sich um einen bei Wei\u00dfbauch - igeln bisher nicht beschriebenen Hirntumor handelt. Die bei der Obduktion festgestellte hochgradige F\u00fcllung und Dilatation der Harnblase wurde vermutlich durch eine tumorbedingte zentrale Blockade des Blasenentleerungszentrums hervorgerufen. Auch bei jungen Igeln sollte im Fall neurologischer Symptome an einen prim\u00e4ren Gehirntumor gedacht werden. Differenzialdiagnostisch sind entz\u00fcndlich-infekti\u00f6se (Tollwut, Herpes, Baylisaskariose), degenerative (Kardiomyopathie, Bandscheibenerkrankung), traumatische, aliment\u00e4re (Vitamin-B-Mangel) und metabolisch-toxische (Hitze-K\u00e4lte-Starre, hepatische Enzephalopathie) Noxen auszuschlie\u00dfen.<\/jats:p>","DOI":"10.15654\/tpk-160112","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T07:28:13Z","timestamp":1473146893000},"page":"348-354","source":"Crossref","is-referenced-by-count":5,"title":["Oligodendrogliom mit neuronaler Differenzierung bei einem 8 Monate alten Afrikanischen Wei\u00dfbauchigel (Atelerix albiventris)"],"prefix":"10.15654","volume":"44","author":[{"given":"Iris","family":"V\u00f6lker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Schwarze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina E.","family":"Brezina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"K\u00f6stlinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Hewicker-Trautwein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"key":"10.15654\/TPK-160112-1","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2001.0518"},{"key":"10.15654\/TPK-160112-2","doi-asserted-by":"crossref","unstructured":"Baumg\u00e4rtner W, Wohlsein P. 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