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Die Studie \u00fcberpr\u00fcfte anhand klinischer Symptomatik sowie zytologischer und bakteriologischer\/mykologischer Befunde die In-vivo-Wirksamkeit eines mit Wirkstoffen angereicherten Gelpr\u00e4parats mit Marbofloxacin, Dexamethason und Enilconazol im Vergleich zu einem kommerziellen, Marbofloxacin, Dexamethason und Clotrimazol enthaltenden Otologikum. Material und Methoden: Bei 41 Hunden mit OE kam das Gelpr\u00e4parat (Gruppe A) bzw. ein zugelassenes Otologikum (Gruppe B) zum Einsatz. Ausgewertet wurden 50 Ohren (je 25 pro Gruppe). Das Gelpr\u00e4parat wurde an Tag 0 und 5 eingebracht und das Kombinationspr\u00e4parat t\u00e4glich nach Herstellerangaben appliziert. Klinische und zytologische Kontrollen fanden nach 5 und 10 Tagen statt. Zu Beginn und nach 10 Tagen wurden Tupferproben bakteriologisch sowie mykologisch untersucht. Ergebnisse: Klinisch und zytologisch lie\u00df sich zwischen den Gruppen kein signifikanter Unterschied feststellen. In beiden Gruppen war die Steigerung negativer bakteriologischer Befunde vergleichbar. In Gruppe A wurden nach 10 Tagen signifikant mehr marbofloxacinresistente Isolate identifiziert, obwohl der Wirkstoff Marbofloxacin in vitro \u00fcber einen Zeitraum von 15 Tagen noch zu \u00fcber 98% verf\u00fcgbar war. Schlussfolgerung: Die zweimalige Anwendung des mit definierten Wirkstoffen angefertigten Gels kann klinisch und zytologisch als vergleichbar mit der t\u00e4glichen Anwendung eines zugelassenen Otologikums angesehen werden. Die Gefahr einer Resistenzentwicklung gegen Fluorchinolone ist bei Anwendung des Gels im Vergleich zu dem zugelassenen Otologikum eher vorhanden. Lokale Nebenwirkungen k\u00f6nnten bei Anwendung des Gels auftreten. Klinische Relevanz: Ein mit Wirkstoffen versehenes Gelatinepr\u00e4parat kann bei Otitis externa des Hundes eine Alternative zur t\u00e4glichen Applikation von Lokaltherapeutika sein. Die Entwicklung von Resistenzen ist m\u00f6glich.<\/jats:p>","DOI":"10.15654\/tpk-160234","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T09:55:41Z","timestamp":1496915741000},"page":"235-244","source":"Crossref","is-referenced-by-count":1,"title":["In-vivo-Wirksamkeit eines Ohrmedikaments mit Gelatinepulver als Wirkstofftr\u00e4ger bei der Therapie kaniner Otitis externa"],"prefix":"10.15654","volume":"45","author":[{"given":"Ralf","family":"Mueller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosima","family":"Bouassiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"10.15654\/TPK-160234-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2003.10.005"},{"key":"10.15654\/TPK-160234-2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(01)50072-8"},{"issue":"15","key":"10.15654\/TPK-160234-3","first-page":"399","volume":"177","author":"Anonymous","year":"2015","journal-title":"The Vet Rec"},{"key":"10.15654\/TPK-160234-4","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.56.67"},{"key":"10.15654\/TPK-160234-5","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(88)50076-1"},{"issue":"1","key":"10.15654\/TPK-160234-6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00405-002-0494-6","volume":"260","author":"Bahadior","year":"2003","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.15654\/TPK-160234-7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1996.tb13774.x"},{"key":"10.15654\/TPK-160234-8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2003.10.013"},{"issue":"K","key":"10.15654\/TPK-160234-9","first-page":"161","volume":"40","author":"Bouassiba","year":"2012","journal-title":"Tier\u00e4rztl Prax"},{"issue":"K","key":"10.15654\/TPK-160234-10","first-page":"7","volume":"41","author":"Bouassiba","year":"2013","journal-title":"Tier\u00e4rztl Prax"},{"key":"10.15654\/TPK-160234-11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01075.x"},{"key":"10.15654\/TPK-160234-12","unstructured":"Bundesamt f\u00fcr Verbraucherschutz und Lebensmittelsicherheit. 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