{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:09:02Z","timestamp":1774361342652,"version":"3.50.1"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Bei einem aus anderen Gr\u00fcnden vorgestellten 12 Jahre alten Labrador-Retriever-R\u00fcden bestand als Nebenbefund eine Hyperadrenokortizismus-Symptomatik (Polyurie\/Polydipsie, tonniges Abdomen, Muskelatrophie). Abweichende Laborbefunde und sonographische Ver\u00e4nderungen der Nebennieren, aber negative Befunde in Low-Dose-Dexamethason-Suppressionstests bei niedriger Basalkortisolkonzentration, ein negativer ACTH-Stimulationstest und Ausschluss eines iatrogenen Hyperadrenokortizismus lie\u00dfen den Verdacht auf einen atypischen Hype radrenokortizismus (AHAC) aufkommen. Die Ergebnisse weiterf\u00fchrender Untersuchungen, insbesondere die Stimulation der Progesteronbildung durch ACTH (0-h-Wert: 0,21 ng\/ml; 1-h-Wert: 4,9 ng\/ml), und das Ansprechen auf die Trilostan-Therapie sprachen ebenfalls f\u00fcr diese Diagnose. Es muss jedoch kritisch hinterfragt werden, ob und inwiefern zus\u00e4tzlich vorliegende Erkrankungen (Arthrosen, Umfangsvermehrung in einem Hoden) hinsichtlich Symptomatik und Laborbefunden eine Rolle gespielt haben. Dieser Fall verdeutlicht die Schwierigkeiten bei der Diagnostik eines AHAC.<\/jats:p>","DOI":"10.15654\/tpk-160255","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T12:12:53Z","timestamp":1493295173000},"page":"186-192","source":"Crossref","is-referenced-by-count":1,"title":["Atypisches Cushing-Syndrom bei einem Hund"],"prefix":"10.15654","volume":"45","author":[{"given":"Stefanie","family":"Hoffrogge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Fels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Schmicke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Mischke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"10.15654\/TPK-160255-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2009.11.002"},{"issue":"3","key":"10.15654\/TPK-160255-2","first-page":"681","volume":"25","author":"Behrend","year":"2011","journal-title":"J Vet Intern Med"},{"issue":"3","key":"10.15654\/TPK-160255-3","first-page":"681","volume":"25","author":"Behrend","year":"2011","journal-title":"J Vet Intern Med"},{"key":"10.15654\/TPK-160255-4","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12192"},{"key":"10.15654\/TPK-160255-5","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.1095"},{"key":"10.15654\/TPK-160255-6","doi-asserted-by":"publisher","DOI":"10.2460\/javma.236.11.1208"},{"key":"10.15654\/TPK-160255-7","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.214"},{"key":"10.15654\/TPK-160255-8","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-35-3-200"},{"key":"10.15654\/TPK-160255-9","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90559-P"},{"issue":"11","key":"10.15654\/TPK-160255-10","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.2460\/javma.1979.174.11.1211","volume":"174","author":"Ling","year":"1979","journal-title":"J Am Vet Med Assoc"},{"key":"10.15654\/TPK-160255-11","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(02)00100-5"},{"key":"10.15654\/TPK-160255-12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.00959.x"},{"key":"10.15654\/TPK-160255-13","unstructured":"Nelson RW. 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