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Eine erh\u00f6hte Gesamtkalzium-Konzentration sollte grunds\u00e4tzlich abgekl\u00e4rt und durch Messung der Konzentration von ionisiertem Kalzium verifiziert werden. Die weitere diagnostische Aufarbeitung richtet sich nach der H\u00f6he der Phosphatkonzentration. Gegebenenfalls sind ein Tumorscreening, die Messung von Parathormon und Parathormon-\u00e4hnlichem Protein sowie eine sonographische Untersuchung der Nebenschilddr\u00fcsen erforderlich. \u00dcberschreitet das Kalzium-Phosphat-Produkt (Werte in mg\/dl) den Wert 60, besteht die Gefahr der Mineralisation von Geweben und eine schnelle Behandlung ist wichtig. Zur Akutbehandlung k\u00f6nnen Infusionen physiologischer Kochsalzl\u00f6sung, Furosemid und Glukokortikoide eingesetzt werden. Glukokortikoide sollten jedoch nur nach strenger Indikation und bereits gestellter Diagnose verwendet werden. Beim Langzeitmanagement kommen zunehmend Bisphosphonate, insbesondere Alendronat, erfolgreich zur Anwendung. Die kausale Therapie des PH erfolgt mittels Parathyreoidektomie, Hitzeablation oder Ethanolablation. Im Anschluss kann, insbesondere bei ausgepr\u00e4gter pr\u00e4operativer Hyperkalz\u00e4mie, eine Hypokalz\u00e4mie auftreten. Zur Behandlung wird Vitamin D3 (Calcitriol) verabreicht (bei starker Hyperkalz\u00e4mie gegebenenfalls bereits pr\u00e4operativ zur Prophylaxe). Eine begleitende orale Kalziumsupplementation mit Kalziumkarbonat als Mittel der Wahl wird kontrovers diskutiert. Aufgrund der Rezidivgefahr nach erfolgreicher Entfernung der bei einem PH betroffenen Nebenschilddr\u00fcse sollte der Serumkalziumspiegel periodisch kontrolliert werden.<\/jats:p>","DOI":"10.15654\/tpk-160923","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T08:14:15Z","timestamp":1490775255000},"page":"122-133","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostische Aufarbeitung und Management der Hyperkalz\u00e4mie des Hundes am Beispiel des prim\u00e4ren Hyperparathyreoidismus"],"prefix":"10.15654","volume":"45","author":[{"given":"Astrid","family":"Wehner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Z\u00f6llner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Hartmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Unterer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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