{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T07:27:26Z","timestamp":1710401246933},"reference-count":0,"publisher":"Paediatrician Publishers LLC","issue":"5","license":[{"start":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T00:00:00Z","timestamp":1449100800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals RAMS"],"abstract":"<jats:p>Until now, there is no systematic information on the role of endothelial dysfunction in the mechanisms of disorders of blood coagulation potential and\u00a0microcirculation in different organs and tissues in preeclampsia.Objective: Our aim was to extend the existing principles of diagnosis of pre-eclampsia\u00a0by establishing the role of endothelial dysfunction in the mechanisms of blood coagulation potential violations. Methods: A prospective comparative\u00a0study was performed. Condition of coagulation processes studied by conventional techniques, parameters of a functional endothelium (nitric oxide\u00a0metabolites, endothelin 1, thrombospondin, thrombomodulin and intercellular adhesion molecules in blood plasma) \u2014 by ELISA.Results: The study\u00a0group included 55 patients with moderate preeclampsia and 49 pregnant women with severe pre-eclampsia, in the control group \u2014 40 women with\u00a0physiological pregnancy. In patients with pre-eclampsia moderate observed increase in plasma endothelin-1 (p 0.001), thrombospondin (p 0.001),\u00a0intercellular adhesion molecules (p 0.001) while reducing the level of nitrogen oxide (p 0.001), increase in time of fibrinolysis (p 0.050) and\u00a0decreased international normalized ratio (p 0.050) compared with the control group. With increasing severity of preeclampsia the researchers\u00a0detected in blood plasma of patients a progressive increase in endothelin 1 (p1 0.020), thrombospondin (p1 0.001), intercellular adhesion molecules\u00a0(p1 0.001) and decrease of nitric oxide metabolites (p1 0.001) and thrombomodulin (p1 0.001); the last combined with the activation of procoagulant\u00a0hemostasis.Conclusion: There is a pathogenetic relationship between the development of endothelial dysfunction, impaired blood coagulation\u00a0potential and the severity of clinical signs of preeclampsia. To widen the number of existing techniques to diagnose the severity of pre-eclampsia we\u00a0recommende to mesure endothelin 1, thrombomodulin, thrombospondin, intercellular adhesion molecules and nitric oxide metabolites in the blood\u00a0plasma, and use traditional indicators to assess the hemostatic system.<\/jats:p>","DOI":"10.15690\/vramn.v70.i5.1448","type":"journal-article","created":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T10:36:53Z","timestamp":1450003013000},"page":"599-603","source":"Crossref","is-referenced-by-count":7,"title":["Pathogenetic Relationship between Endothelial Dysfunction and Disorders of Blood Coagulation Potential in Pregnancy Complicated by Pre-Eclampsia"],"prefix":"10.15690","volume":"70","author":[{"given":"O. N.","family":"Sergeeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. P.","family":"Chesnokova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. V.","family":"Ponukalina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. E.","family":"Rogozhina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. N.","family":"Glukhova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7097","published-online":{"date-parts":[[2015,12,3]]},"container-title":["Annals of the Russian academy of medical sciences"],"original-title":[],"link":[{"URL":"https:\/\/vestnikramn.spr-journal.ru\/jour\/article\/viewFile\/554\/494","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/vestnikramn.spr-journal.ru\/jour\/article\/viewFile\/554\/494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T14:30:07Z","timestamp":1573482607000},"score":1,"resource":{"primary":{"URL":"https:\/\/vestnikramn.spr-journal.ru\/jour\/article\/view\/554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,3]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,12,3]]}},"URL":"https:\/\/doi.org\/10.15690\/vramn.v70.i5.1448","relation":{},"ISSN":["2414-3545","0869-6047"],"issn-type":[{"value":"2414-3545","type":"electronic"},{"value":"0869-6047","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12,3]]}}}