{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:01:14Z","timestamp":1790917274021,"version":"4.1.0"},"reference-count":0,"publisher":"Paediatrician Publishers LLC","issue":"6","license":[{"start":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T00:00:00Z","timestamp":1449100800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals RAMS"],"abstract":"<jats:p>Aim of study. To evaluate clinical significance of different combinations of gene polymorphisms IL-1b, IL-6, IL-10, TNF, HFE, TGF-b, ATR1, NOS3894, CYBA, AGT, MTHFR, FII, FV, FVII, FXIII, ITGA2, ITGB3, FBG, PAI and their prognostic value for prediction of liver fibrosis progression rate in patients with chronic hepatitis C (CHC).Subjects and methods: 118 patients with CHC were divided into \u00abfast\u00bb and \u00abslow\u00bb (fibrosis rate progression \u22650,13 and 0,13 fibrosis units\/yr; n =64 and n =54) fibrosis groups. Gene polymorphisms were determined. Statistical analysis was performed using Statistica 10.Results. A allele (p =0,012) and genotype AA (p =0,024) of AGT G-6T gene, as well as T allele (p =0,013) and MT+TT genotypes (p =0,005) of AGT 235 M\/T gene were significantly more common in \u00abfast fibrosers\u00bb than in \u00abslow fibrosers\u00bb. Patients with genotype TT of CYBA 242 C\/T had a higher fibrosis progression rate than patients with CC+CT genotype (p =0,02). Our analysis showed a protective effect of TT genotype of ITGA2 807 C\/T on fibrosis progression rate (p =0,03). There was a trend (p 0,15) to higher fibrosis progression rate in patients with mutant alleles and genotypes of TGFb +915 G\/C, FXIII 103 G\/T, PAI -675 5G\/4G genes. Other gene polymorphisms were not associated with enhanced liver fibrosis. To build a mathematical model for prediction of liver fibrosis progression rate we performed coding with scores for genotypes and virus genotype. Total score correlated with the fibrosis progression rate (R =0,39, p =0,000).Conclusion: Determination of genetic profile of the patient and virus genotype allows to predict the course of CHC.\u00a0<\/jats:p>","DOI":"10.15690\/vramn548","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T23:00:47Z","timestamp":1453849247000},"page":"651-661","source":"Crossref","is-referenced-by-count":3,"title":["Mathematic Model for Prediction of Liver Fibrosis Progression Rate in Patients with Chronic Hepatitis C Based on Combination of Genomic Markers"],"prefix":"10.15690","volume":"70","author":[{"given":"Larisa Mikhaylovna","family":"Samokhodskaia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina Evgen'evna","family":"Starostina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Borisovna","family":"Yarovaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tat'yana Nikolaevna","family":"Krasnova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay Alekseevich","family":"Mukhin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vsevolod Arsen'evich","family":"Tkachuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor Antonovich","family":"Sadovnichy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7097","published-online":{"date-parts":[[2015,12,3]]},"container-title":["Annals of the Russian academy of medical sciences"],"original-title":[],"link":[{"URL":"https:\/\/vestnikramn.spr-journal.ru\/jour\/article\/viewFile\/548\/554","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/vestnikramn.spr-journal.ru\/jour\/article\/viewFile\/548\/554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T14:30:10Z","timestamp":1573482610000},"score":1,"resource":{"primary":{"URL":"https:\/\/vestnikramn.spr-journal.ru\/jour\/article\/view\/548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,3]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,12,31]]}},"URL":"https:\/\/doi.org\/10.15690\/vramn548","relation":{},"ISSN":["2414-3545","0869-6047"],"issn-type":[{"value":"2414-3545","type":"electronic"},{"value":"0869-6047","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12,3]]}}}