{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:59:41Z","timestamp":1790762381104,"version":"4.1.0"},"reference-count":0,"publisher":"Shared Science Publishers OG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CST"],"abstract":"<jats:p>In a recent issue in Nature Cell Biology, Sung Min Son et al. unveil a novel layer in the regulation of the mTORC1\/autophagy axis by EP300 which can undergo nucleocytoplasmic shuttling in response to alterations in nutrient availability. The study highlights that, in Hutchinson-Gilford progeria syndrome, overabundant cytoplasmic EP300 results in mTORC1 hyperactivation and impaired autophagy, potentially contributing to premature and accelerated aging.<\/jats:p>","DOI":"10.15698\/cst2024.04.295","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T12:33:56Z","timestamp":1714394036000},"page":"51-55","source":"Crossref","is-referenced-by-count":2,"title":["Pathogenic hyperactivation of mTORC1 by cytoplasmic EP300 in Hutchinson-Gilford progeria syndrome"],"prefix":"10.15698","volume":"08","author":[{"given":"Lucille","family":"Ferret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Kroemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Djavaheri-Mergny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6394","published-online":{"date-parts":[[2024,4,30]]},"container-title":["Cell Stress"],"original-title":[],"link":[{"URL":"http:\/\/www.cell-stress.com\/wp-content\/uploads\/2024A-Ferret-Cell-Stress.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T12:33:58Z","timestamp":1714394038000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.cell-stress.com\/researcharticles\/2024a-ferret-cell-stress\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.15698\/cst2024.04.295","relation":{},"ISSN":["2523-0204"],"issn-type":[{"value":"2523-0204","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,30]]}}}