{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T13:41:05Z","timestamp":1777038065495,"version":"3.51.4"},"reference-count":128,"publisher":"Shared Science Publishers OG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title id=\"abstract-title-5b9e3a4796a62eb8c706b57257N65750\">Abstract<\/jats:title>\n                  <jats:p id=\"paragraph-5b9e3a4796a62eb8c706b57258N65752\">Fungal infections pose a significant global health threat with rising morbidity and mortality rates. However, the repertoire of effective antifungal drugs remains narrow, a challenge that is further exacerbated by the increasing emergence of (multi)drug-resistant strains. This underscores the urgent need for novel therapeutic strategies. Among them, antifungal peptides (AFPs) have emerged as a promising alternative. AFPs are small, naturally occurring peptides produced by a wide range of organisms, including plants, animals, fungi, and bacteria, as part of their innate immune defense. In addition, synthetic and semisynthetic variants have also been engineered. We here underscore the potential of AFPs as viable candidates for the development of next-generation antifungal therapies. In particular, we advocate their multimodal advantage that spans beyond standalone activity, including their synergistic and immune-regulatory potential.<\/jats:p>","DOI":"10.15698\/cst2026.01.315","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:35:21Z","timestamp":1770150921000},"page":"9-18","source":"Crossref","is-referenced-by-count":1,"title":["Antifungal peptides: From modes of action to synergistic and immunologic potential"],"prefix":"10.15698","volume":"10","author":[{"given":"Didac","family":"Carmona-Gutierrez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Kainz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin N.","family":"Odabas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Madeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6394","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"issue":"6","key":"b00690","doi-asserted-by":"crossref","first-page":"143","DOI":"10.15698\/mic2020.06.718","article-title":"Fungal infections in humans: the silent crisis","volume":"7","author":"Kainz","year":"2020","journal-title":"Microbial Cell"},{"issue":"7","key":"b00710","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.1016\/S1473-3099(23)00692-8","article-title":"Global incidence and mortality of severe fungal disease","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect Dis"},{"issue":"9","key":"b00769","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3390\/genes9090461","article-title":"Evolutionary emergence of drug resistance in Candida opportunistic pathogens","volume":"9","author":"Ksiezopolska","year":"2018","journal-title":"Genes"},{"issue":"9","key":"b007cc","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41579-022-00720-1","article-title":"Tackling the emerging threat of antifungal resistance to human health","volume":"20","author":"Fisher","year":"2022","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"b0091c","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s12281-010-0035-5","article-title":"Fungal biofilms: relevance in the setting of human disease","volume":"4","author":"Martinez","year":"2010","journal-title":"Curr Fungal Infect Rep"},{"issue":"suppl_3","key":"b00982","doi-asserted-by":"crossref","first-page":"S431","DOI":"10.1093\/infdis\/jix179","article-title":"Antifungal resistance: an emerging reality and a global challenge","volume":"216","author":"Kontoyiannis","year":"2017","journal-title":"J Infect Dis"},{"issue":"4","key":"b009db","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01397-19","article-title":"On the emergence of Candida auris: climate change azoles, swamps, and birds","volume":"10","author":"Casadevall","year":"2019","journal-title":"mBio"},{"issue":"8","key":"b00a49","doi-asserted-by":"crossref","first-page":"141","DOI":"10.15698\/mic2022.08.782","article-title":"The rise of Candida auris: from unique traits to co-infection potential","volume":"9","author":"Egger","year":"2022","journal-title":"Microbial Cell"},{"key":"b00ae3","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/615958","article-title":"Non-albicans Candida infection: an emerging threat","volume":"2014","author":"Deorukhkar","year":"2014","journal-title":"Interdiscip Perspect Infect Dis"},{"key":"b00b4e","unstructured":"WHO fungal priority pathogens list to guide research, development and public health action. 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