{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:51:01Z","timestamp":1783003861669,"version":"3.54.5"},"reference-count":50,"publisher":"Shared Science Publishers OG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title id=\"abstract-title-7e0c074272a94389bd50d3271f6fc80c\">Abstract<\/jats:title>\n               <jats:p id=\"paragraph-b1d14f292aac4835af1bb77c7770beec\">Alcohol-associated liver disease is highly prevalent worldwide, with alcohol-associated hepatitis as a severe form characterized by substantial morbidity, mortality, and economic burden. Gut bacterial dysbiosis has been linked to progression of alcohol-associated hepatitis. Fecal cytolysin secreted by the pathobiont <jats:italic>Enterococcus faecalis<\/jats:italic> (<jats:italic>E. faecalis<\/jats:italic>) is associated with increased mortality in patients with alcohol-associated hepatitis. Although gelatinase is considered a virulence factor in <jats:italic>E. faecalis<\/jats:italic>, its prevalence and impact on alcohol-associated hepatitis patient outcomes remains unclear. In this study, 20 out of 65 (30.8%) patients with alcohol-associated hepatitis tested positive for gelatinase in their stool. There were no significant differences in 30-day and 90-day mortality between gelatinase-positive and gelatinase-negative patients (p=0.97 and p=0.48, respectively). Fecal gelatinase had a low discriminative ability for 30-day mortality (area under the curve [AUC] 0.50 vs fibrosis-4 Index (FIB-4) 0.75) and 90-day mortality compared with other established liver disease markers (AUC 0.57 vs FIB-4 0.79 or \u2018age, serum bilirubin, INR, and serum creatinine\u2019 (ABIC) score 0.78). Furthermore, fecal gelatinase was not an important feature for 30-day or 90-day mortality per random forest analysis. Finally, gelatinase-positive patients with alcohol-associated hepatitis did not exhibit more severe liver disease compared with gelatinase-negative patients. In conclusion, fecal gelatinase does not predict mortality or disease severity in patients with alcohol-associated hepatitis from our cohort.<\/jats:p>","DOI":"10.15698\/mic2024.08.836","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T14:05:47Z","timestamp":1729692347000},"page":"328-338","source":"Crossref","is-referenced-by-count":1,"title":["Fecal gelatinase does not predict mortality in patients with alcohol-associated 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