{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T14:48:21Z","timestamp":1777819701550,"version":"3.51.4"},"reference-count":35,"publisher":"International Society of Endovascular Specialists","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endovascular Therapy"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1583\/08-2385.1","type":"journal-article","created":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T16:17:41Z","timestamp":1217607461000},"page":"399-407","source":"Crossref","is-referenced-by-count":14,"title":["Homocysteine, the Cholesterol of the 21\n                    <sup>st<\/sup>\n                    Century. Impact of Hyperhomocysteinemia on Patency and Amputation-Free Survival After Intervention for Critical Limb Ischemia"],"prefix":"10.1583","volume":"15","author":[{"given":"Helen M.","family":"Heneghan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif","family":"Sultan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"527","reference":[{"key":"i1545-1550-15-4-399-b1","unstructured":"M. Naruszewicz, E. Mirkiewicz, and A. J. Olszewski .et al.Thiolation of low-density lipoprotein by homocysteine thiolactone causes increased aggregation and altered interaction with cultured macrophages., Nutr Metab Cardiovasc Dis, 1994 .4 :70 \u201377 ."},{"key":"i1545-1550-15-4-399-b2","unstructured":"K. S. McCully, Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis., Am J Pathol, 1969 .56 :111 \u2013128 ."},{"key":"i1545-1550-15-4-399-b3","doi-asserted-by":"crossref","unstructured":"C. J. Boushey, S. A. Beresford, and G. S. Omenn .et al.A quantitative assessment of plasma homocysteine as a risk factor for vascular disease., JAMA, 1995 .274 :1049 \u20131057 .","DOI":"10.1001\/jama.1995.03530130055028"},{"key":"i1545-1550-15-4-399-b4","doi-asserted-by":"crossref","unstructured":"K. S. McCully, Homocysteine and vascular disease., Nat Med, 1996 .2 :386 \u2013389 .","DOI":"10.1038\/nm0496-386"},{"key":"i1545-1550-15-4-399-b5","doi-asserted-by":"crossref","unstructured":"E. Laxdal, J. Wirsching, and G. Pedersen .et al.Homocysteine levels, haemostatic risk factors and patency rates after endovascular treatment of the common iliac arteries., Eur J Vasc Endovasc Surg, 2006 .31 :244 \u2013250 .","DOI":"10.1016\/j.ejvs.2005.06.032"},{"key":"i1545-1550-15-4-399-b6","doi-asserted-by":"crossref","unstructured":"E. K. Hoogeveen, P. J. Kostense, and C. Jakobs .et al.Hyperhomocysteinaemia is not associated with isolated crural arterial occlusive disease: the Hoorn Study., J Intern Med, 2000 .247 :442 \u2013448 .","DOI":"10.1046\/j.1365-2796.2000.00623.x"},{"key":"i1545-1550-15-4-399-b7","doi-asserted-by":"crossref","unstructured":"L. Norgren, W. R. Hiatt, and J. A. Dormandy .et al.Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)., J Vasc Surg, 2007 .45 Suppl S :S5 \u201367 .","DOI":"10.1016\/j.jvs.2006.12.037"},{"key":"i1545-1550-15-4-399-b8","doi-asserted-by":"crossref","unstructured":"A. B. Guttormsen, J. Schneede, and T. Fiskerstrand .et al.Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy subjects., J Nutr, 1994 .124 :1934 \u20131941 .","DOI":"10.1093\/jn\/124.10.1934"},{"key":"i1545-1550-15-4-399-b9","doi-asserted-by":"crossref","unstructured":"T. Fiskerstrand, H. Refsum, and G. Kvalheim .et al.Homocysteine and other thiols in plasma and urine: automated determination and sample stability., Clin Chem, 1993 .39 :263 \u2013271 .","DOI":"10.1093\/clinchem\/39.2.263"},{"key":"i1545-1550-15-4-399-b10","doi-asserted-by":"crossref","unstructured":"J. Moller, and K. Rasmussen .Homocysteine in plasma: stabilization of blood samples with fluoride., Clin Chem, 1995 .41 :758 \u2013759 .","DOI":"10.1093\/clinchem\/41.5.758"},{"key":"i1545-1550-15-4-399-b11","doi-asserted-by":"crossref","unstructured":"U. C. Garg, Z. J. Zheng, and A. R. Folsom .et al.Short-term and long-term variability of plasma homocysteine measurement., Clin Chem, 1997 .43 :141 \u2013145 .","DOI":"10.1093\/clinchem\/43.1.141"},{"key":"i1545-1550-15-4-399-b12","unstructured":"H. M. Heneghan, W. Tawfick, and S. Sultan .Prevalence and correlation of hyperhomocysteinemia to amputation-free survival, major adverse events and mortality after intervention for critical lower limb ischemia in patients with peripheral vascular disease [abstract]., J Vasc Interv Radiol, 2007 .18 :1615 ."},{"key":"i1545-1550-15-4-399-b13","unstructured":"H. M. Heneghan, W. Tawfick, and S. Sultan .Prevalence and correlation of hyperhomocysteinemia to major adverse events, amputation free survival and mortality in patients managed by endovascular intervention or bypass surgery for critical lower limb ischaemia [abstract]., Ir J Med Sci, 2007 .176 :(S2).70 ."},{"key":"i1545-1550-15-4-399-b14","doi-asserted-by":"crossref","unstructured":"R. B. Rutherford, J. D. Baker, and C. Ernst .et al.Recommended standards for reports dealing with lower extremity ischemia: revised version., J Vasc Surg, 1997 .26 :517 \u2013538 .","DOI":"10.1016\/S0741-5214(97)70045-4"},{"key":"i1545-1550-15-4-399-b15","doi-asserted-by":"crossref","unstructured":"M. A. Allison, E. Ho, and J. O. Denenberg .et al.Ethnic-specific prevalence of peripheral arterial disease in the United States., Am J Prev Med, 2007 .32 :328 \u2013333 .","DOI":"10.1016\/j.amepre.2006.12.010"},{"key":"i1545-1550-15-4-399-b16","doi-asserted-by":"crossref","unstructured":"D. S. Wald, M. Law, and J. K. Morris .Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis., BMJ, 2002 .325 :1202 .","DOI":"10.1136\/bmj.325.7374.1202"},{"key":"i1545-1550-15-4-399-b17","doi-asserted-by":"crossref","unstructured":"S. J. Lewis, S. Ebrahim, and G. Davey Smith .Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? BMJ, 2005 .331 :1053 .","DOI":"10.1136\/bmj.38611.658947.55"},{"key":"i1545-1550-15-4-399-b18","unstructured":"E. Lonn, Homocysteine in the prevention of ischemic heart disease, stroke, and venous thromboembolism: therapeutic target or just another distraction? Curr Opin Hematol, 2007 .14 :481 \u2013487 ."},{"key":"i1545-1550-15-4-399-b19","doi-asserted-by":"crossref","unstructured":"M. Hansrani, and G. Stansby .Homocysteine lowering interventions for peripheral arterial disease and bypass grafts., Cochrane Database Syst Rev, 2002 .3 :CD003285 .","DOI":"10.1002\/14651858.CD003285"},{"key":"i1545-1550-15-4-399-b20","doi-asserted-by":"crossref","unstructured":"D. S. Wald, N. J. Wald, and J. K. Morris .et al.Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence., BMJ, 2006 .333 :1114 \u20131117 .","DOI":"10.1136\/bmj.39000.486701.68"},{"key":"i1545-1550-15-4-399-b21","doi-asserted-by":"crossref","unstructured":"P. K. Lindenauer, P. Pekow, and K. Wang .et al.Lipid-lowering therapy and in-hospital mortality following major noncardiac surgery., JAMA, 2004 .291 :2092 \u20132099 .","DOI":"10.1001\/jama.291.17.2092"},{"key":"i1545-1550-15-4-399-b22","doi-asserted-by":"crossref","unstructured":"P. K. Lindenauer, P. Pekow, and K. Wang .et al.Peri-operative beta-blocker therapy and mortality after major noncardiac surgery., N Eng J Med, 2005 .353 :349 \u2013361 .","DOI":"10.1056\/NEJMoa041895"},{"key":"i1545-1550-15-4-399-b23","doi-asserted-by":"crossref","unstructured":"A. Raghunathan, J. H. Rapp, and F. Littooy .et al.Postoperative outcomes for patients undergoing elective revascularization for critical limb ischemia and intermittent claudication: a subanalysis of the Coronary Artery Revascularization Prophylaxis (CARP) trial., J Vasc Surg, 2006 .43 :1175 \u20131182 .","DOI":"10.1016\/j.jvs.2005.12.069"},{"key":"i1545-1550-15-4-399-b24","unstructured":"K. Oaikhinan, and S. Sultan .An observational parallel group comparative study with and without the \u201cmagic bullet\u201d (aspirin, cardioselective beta-blocker, pravastatin, and clopidogrel) in the perioperative and postoperative period for abdominal aortic aneurysms surgery and femoropopliteal segment revascularization. Does the \u201cMagic Bullet\u201d improve the 30-day morbidity and mortality outcome? Br J Surg, 2004 .91;1 :113 \u2013114 ."},{"key":"i1545-1550-15-4-399-b25","doi-asserted-by":"crossref","unstructured":"J. I. Spark, P. Laws, and R. Fitridge .The incidence of hyperhomocysteinaemia in vascular patients., Eur J Vasc Endovasc Surg, 2003 .26 :558 \u2013561 .","DOI":"10.1016\/S1078-5884(03)00381-2"},{"key":"i1545-1550-15-4-399-b26","unstructured":"J. Nilsson, J. Regnstrom, and J. Frostegard .et al.Lipid oxidation and atherosclerosis., Herz, 1992 .17 :263 \u2013269 ."},{"key":"i1545-1550-15-4-399-b27","doi-asserted-by":"crossref","unstructured":"I. M. Graham, and P. O'Callaghan .Vitamins, homocysteine and cardiovascular risk., Cardiovasc Drugs Ther, 2002 .16 :383 \u2013389 .","DOI":"10.1023\/A:1022126100625"},{"key":"i1545-1550-15-4-399-b28","doi-asserted-by":"crossref","unstructured":"H. Refsum, E. Nurk, and A. D. Smith .et al.The Hordaland Homocysteine Study: a community based study of homocysteine, its determinants, and associations with disease., J Nutr, 2006 .136 :1731S \u20131740S .","DOI":"10.1093\/jn\/136.6.1731S"},{"key":"i1545-1550-15-4-399-b29","doi-asserted-by":"crossref","unstructured":"L. M. Taylor, G. L. Moneta, and G. J. Sexton .et al.Prospective blinded study of the relationship between plasma homocysteine and progression of symptomatic peripheral arterial disease., J Vasc Surg, 1999 .29 :8 \u201321 .","DOI":"10.1016\/S0741-5214(99)70345-9"},{"key":"i1545-1550-15-4-399-b30","doi-asserted-by":"crossref","unstructured":"H. C. Looker, A. Fagot-Campagna, and E. W. Gunter .et al.Homocysteine and vitamin B12 concentrations and mortality rates in type 2 diabetes., Diabetes Metab Res Rev, 2005 .23 :193 \u2013201 .","DOI":"10.1002\/dmrr.660"},{"key":"i1545-1550-15-4-399-b31","doi-asserted-by":"crossref","unstructured":"A. Mazza, E. Bossone, and F. Mazza .et al.Reduced serum homocysteine levels in type 2 diabetes., Nutr Metab Cardiovasc Dis, 2005 .Apr;15 :118 \u2013124 .","DOI":"10.1016\/j.numecd.2004.03.001"},{"key":"i1545-1550-15-4-399-b32","doi-asserted-by":"crossref","unstructured":"M. Emoto, H. Kanda, and T. Shoji .et al.Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes., Diabetes Care, 2001 .24 :533 \u2013538 .","DOI":"10.2337\/diacare.24.3.533"},{"key":"i1545-1550-15-4-399-b33","doi-asserted-by":"crossref","unstructured":"M. Buysschaert, A. S. Dramais, and P. E. Wallemacq .et al.Hyperhomocysteinemia in type 2 diabetes., Diabetes Care, 2000 .23 :1816 \u20131822 .","DOI":"10.2337\/diacare.23.12.1816"},{"key":"i1545-1550-15-4-399-b34","doi-asserted-by":"crossref","unstructured":"Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration., BMJ, 1998 .316 :894 \u2013898 .","DOI":"10.1136\/bmj.316.7135.894"},{"key":"i1545-1550-15-4-399-b35","doi-asserted-by":"crossref","unstructured":"W. Herrmann, Homocysteine research: alive and kicking!, Clin Chem Lab Med, 2007 .45 :1571 \u20131574 .","DOI":"10.1515\/CCLM.2007.359"}],"container-title":["Journal of Endovascular Therapy"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:28:51Z","timestamp":1777498131000},"score":1,"resource":{"primary":{"URL":"http:\/\/jet.sagepub.com\/lookup\/doi\/10.1583\/08-2385.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1583\/08-2385.1"],"URL":"https:\/\/doi.org\/10.1583\/08-2385.1","relation":{},"ISSN":["1526-6028","1545-1550"],"issn-type":[{"value":"1526-6028","type":"print"},{"value":"1545-1550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}