{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:09:16Z","timestamp":1788430156047,"version":"build-2803163510"},"reference-count":85,"publisher":"Informa UK Limited","issue":"9","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Anti-infective Therapy"],"published-print":{"date-parts":[[2014,9,1]]},"DOI":"10.1586\/14787210.2014.945917","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T12:55:10Z","timestamp":1407156910000},"page":"1075-1086","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":16,"title":["New targets in the search for preventive and therapeutic agents for botulism"],"prefix":"10.1586","volume":"12","author":[{"given":"Fabrizio","family":"Anniballi","sequence":"first","affiliation":[{"name":"Department of Veterinary Public Health and Food Safety, National Reference Centre for Botulism, Istituto Superiore di Sanit\u00e0, Viale Regina Elena, 299 \u2013 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Lonati","sequence":"additional","affiliation":[{"name":"Pavia Poison Center and National Toxicology Information Centre, IRCCS Maugeri Foundation and University of Pavia, Via S. Maugeri, 10 \u2013 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonsina","family":"Fiore","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health and Food Safety, National Reference Centre for Botulism, Istituto Superiore di Sanit\u00e0, Viale Regina Elena, 299 \u2013 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Auricchio","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health and Food Safety, National Reference Centre for Botulism, Istituto Superiore di Sanit\u00e0, Viale Regina Elena, 299 \u2013 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"De Medici","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health and Food Safety, National Reference Centre for Botulism, Istituto Superiore di Sanit\u00e0, Viale Regina Elena, 299 \u2013 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Alessandro","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Pavia Poison Center and National Toxicology Information Centre, IRCCS Maugeri Foundation and University of Pavia, Via S. Maugeri, 10 \u2013 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2014,8,4]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1086\/444507"},{"issue":"2","key":"CIT0002","first-page":"134","volume":"45","author":"Fenicia L","year":"2009","journal-title":"Ann Ist Super Sanit\u00e0"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1097\/DMP.0b013e318158c5fd"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.3390\/toxins3050469"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1002\/9780470744307.gat151"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051926"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05261-11"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.08.059"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2012.12.004"},{"key":"CIT0010","first-page":"1057","volume-title":"The microbiological safety and quality of food. (Volume 2)","author":"Lund BM","year":"2000"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2006.02987.x"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2010.03.005"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.8.1059"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2011.12.001"},{"key":"CIT0015","unstructured":"Select agents and toxins list. Available from: www.selectagents.gov"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit449"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit450"},{"key":"CIT0018","first-page":"1","volume":"364","author":"Hill KK","year":"2013","journal-title":"Curr Top Microbiol Immunol"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2013.01.017"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3295"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00449-8"},{"key":"CIT0022","unstructured":"Rummel A. The molecular and structural biology of Clostridium botulinum neurotoxins reveal insights into the sophisticated mechanism of neurotoxicity. In: Clostridium botulinum: a spore forming organism and a challenge to food safety. Rasetti-Escargueil C, Surman-Lee S, editors. Nova Science Publishers Inc; New York, USA: 2012. p. 37-70"},{"key":"CIT0023","author":"Chen S","year":"2013","journal-title":"Curr Protein Pept Sci"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08183.x"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.2.717"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001271"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2013.06.001"},{"key":"CIT0028","first-page":"119","volume-title":"Clostridium botulinum: a spore forming organism and a challenge to food safety","author":"Fujinaga Y","year":"2012"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2911(09)05503-9"},{"key":"CIT0030","first-page":"1","volume-title":"Clostridium botulinum: a spore forming organism and a challenge to food safety","author":"Popoff MR","year":"2012"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01258-09"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2013.02.014"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2014.884066"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2012.05.009"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00382-13"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2010.535003"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2008.05.009"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.4161\/hv.9420"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.03.046"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.064"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00496-09"},{"issue":"8","key":"CIT0042","volume":"10","author":"Yu YZ","year":"2014","journal-title":"Hum Vaccin Immunother"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00166-11"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.3109\/08923971003782327"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087089"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2010.07.003"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1042\/BC20070116"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2013.02.014"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.09.005"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.2174\/187152607780090667"},{"issue":"6","key":"CIT0051","first-page":"839","volume":"25","author":"Shi YL","year":"2004","journal-title":"Acta Pharmacol Sin"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16010202"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)01291-2"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2006.00236.x"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2007.02.002"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.12.042"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.12.030"},{"issue":"1","key":"CIT0058","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0022-3565(25)38691-X","volume":"269","author":"Simpson LL","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1021\/jm4012164"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2009.03.016"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1021\/bi2001483"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.12.001"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1021\/ml100074s"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc04078a"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.02.115"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.10.062"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1021\/cb1002366"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.09.019"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.07.015"},{"key":"CIT0070","first-page":"197","volume":"364","author":"Swaminathan S","year":"2013","journal-title":"Curr Top Microbiol Immunol"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444912003551"},{"issue":"1","key":"CIT0072","first-page":"27","volume":"4","author":"Germer K","year":"2013","journal-title":"Int J Biochem Mol Biol"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1016\/j.meatsci.2004.07.019"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2005.11.003"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2007.12.006"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02572-08"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2010.03.003"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089958"},{"key":"CIT0079","first-page":"111","volume-title":"Foodborne bacterial pathogens","author":"Hauschild AH","year":"1989"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1136\/vr.101184"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.57.12.3423-3428.1991"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.6735"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2013.771632"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1023\/B:EJEP.0000006630.59370.88"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.11.007"}],"container-title":["Expert Review of Anti-infective Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1586\/14787210.2014.945917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T01:59:40Z","timestamp":1746323980000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1586\/14787210.2014.945917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,4]]},"references-count":85,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9,1]]}},"alternative-id":["10.1586\/14787210.2014.945917"],"URL":"https:\/\/doi.org\/10.1586\/14787210.2014.945917","relation":{},"ISSN":["1478-7210","1744-8336"],"issn-type":[{"value":"1478-7210","type":"print"},{"value":"1744-8336","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2014-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}