{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:22:52Z","timestamp":1785439372652,"version":"3.56.0"},"reference-count":76,"publisher":"Informa UK Limited","issue":"3","funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14\/01090"],"award-info":[{"award-number":["PI14\/01090"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Clinical Pharmacology"],"published-print":{"date-parts":[[2016,3,3]]},"DOI":"10.1586\/17512433.2016.1135733","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T06:46:10Z","timestamp":1450853170000},"page":"441-458","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":28,"title":["Variations of pharmacokinetics of drugs in patients with cirrhosis"],"prefix":"10.1586","volume":"9","author":[{"given":"MA","family":"Pena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JF","family":"Horga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Zapater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,1,15]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.12.005"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60383-9"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0553-z"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.121829"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1984.tb02525.x"},{"issue":"1","key":"CIT0006","first-page":"153","volume":"3","author":"Hayes PC","year":"1989","journal-title":"J Hum Hypertens"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1976.tb01531.x"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1974153276"},{"key":"CIT0009","first-page":"403","volume-title":"Clinical pharmacokinetics & pharmacodynamics: concepts and applications","author":"Rowland M","year":"2011"},{"key":"CIT0010","volume-title":"UpToDate","author":"Larson AM","year":"2015"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198815060-00004"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082012000400002"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199427030-00005"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01374.x"},{"key":"CIT0017","first-page":"19","volume":"8","author":"Burra P","year":"2004","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.181.203"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)94639-4"},{"key":"CIT0020","first-page":"162","volume":"22","author":"Balistreri WF","year":"1992","journal-title":"Ann Clin Lab Sci"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1007\/BF02125801"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2001.00370.x"},{"key":"CIT0023","first-page":"246","volume":"39","author":"Wiela-Hojenska A","year":"2001","journal-title":"Int J Clin Pharmacol Ther"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e328012b268"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1086\/426021"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1086\/318501"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12324"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2000.00186.x"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1007\/BF03261935"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2356"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-014-0142-5"},{"key":"CIT0045","first-page":"1004A","volume-title":"Hepatology","author":"Bifano M","year":"2011"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.010"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.7.13.1835"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.5.1721-1726.2006"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050476"},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1128\/AAC.41.12.2793","volume":"41","author":"Schaad HJ","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq320"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.4.821-826.2000"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp140031"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-197601040-00004"},{"key":"CIT0060","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0016-5085(19)31519-7","volume":"73","author":"Marshall JP","year":"1977","journal-title":"Gastroenterology"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.7.1376"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1007\/BF00637745"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1984.210"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.7.1318"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199324010-00004"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/26.suppl_B.61"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199200221-00006"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1993.tb04692.x"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/31.suppl_E.57"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1136\/gut.13.1.47"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90442-8"},{"key":"CIT0072","first-page":"76","volume":"40","author":"Lacroix C","year":"1990","journal-title":"Arzneimittelforschung"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1177\/0091270010363477"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.11.1662"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.3109\/00365528708991867"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544100-00002"},{"key":"CIT0077","first-page":"550","volume":"34","author":"Bourget P","year":"1996","journal-title":"Int J Clin Pharmacol Ther"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02022.x"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.23539"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12312"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20595"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1990.tb03638.x"},{"key":"CIT0083","first-page":"83","volume":"44","author":"Durnin C","year":"2001","journal-title":"Proc West Pharmacol Soc"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(97)90100-4"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.10.038"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.08668.x"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2010.06504.x"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000090741.63156.1B"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1976.tb00599.x"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.3_Suppl.S1"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1155\/1998\/17436"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200746120-00002"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-003-0586-2"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.02.003"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)00340-7"}],"container-title":["Expert Review of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1586\/17512433.2016.1135733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T18:13:28Z","timestamp":1567448008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1586\/17512433.2016.1135733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,15]]},"references-count":76,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,11,18]]},"published-print":{"date-parts":[[2016,3,3]]}},"alternative-id":["10.1586\/17512433.2016.1135733"],"URL":"https:\/\/doi.org\/10.1586\/17512433.2016.1135733","relation":{},"ISSN":["1751-2433","1751-2441"],"issn-type":[{"value":"1751-2433","type":"print"},{"value":"1751-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,15]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierj20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}