{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:09:04Z","timestamp":1781082544771,"version":"3.54.1"},"reference-count":61,"publisher":"Informa UK Limited","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Review of Clinical Immunology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1586\/eci.10.41","type":"journal-article","created":{"date-parts":[[2010,9,9]],"date-time":"2010-09-09T14:47:26Z","timestamp":1284043646000},"page":"735-743","source":"Crossref","is-referenced-by-count":22,"title":["Tocilizumab: molecular intervention therapy in children with systemic juvenile idiopathic arthritis"],"prefix":"10.1586","volume":"6","author":[{"given":"Shumpei","family":"Yokota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamitsu","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2014,1,10]]},"reference":[{"key":"CIT0001","unstructured":"Cassidy JT, Petty RE. Juvenile idiopathic arthritis. In:Textbook of Pediatric Rheumatology (5thEdition). Cassidy JT, Petty RE (Eds). WB Saunders, PA, USA, 291\u2013303 (2005)."},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1182\/blood-2004-08-2997","volume":"105","author":"Billiau","year":"2005","journal-title":"Blood"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1093\/rheumatology\/41.12.1444","volume":"41","author":"Packham","year":"2002","journal-title":"Rheumatology (Oxford)"},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1600-065X.2008.00643.x","volume":"223","author":"Pascual","year":"2008","journal-title":"Immunol. Rev."},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/rheumatology\/kep418","volume":"49","author":"Vastert","year":"2010","journal-title":"Rheumatology"},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1002\/art.24750","volume":"60","author":"de Jager","year":"2009","journal-title":"Arthritis Rheum."},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/art.1780340912","volume":"34","author":"de Benedetti","year":"1991","journal-title":"Arthritis Rheum."},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S1096-6374(02)00135-1","volume":"13","author":"Lieskovska","year":"2003","journal-title":"Growth Horm. IGF Res."},{"key":"CIT0009","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.berh.2009.08.003","volume":"23","author":"Vastert","year":"2009","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.bbi.2007.12.006","volume":"22","author":"Harden","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.semarthrit.2008.01.006","volume":"38","author":"Raj","year":"2009","journal-title":"Semin. Arthritis Rheum."},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0167-4838(00)00153-9","volume":"1482","author":"Fournier","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/j.1365-2443.2005.00900.x","volume":"10","author":"Hagihara","year":"2005","journal-title":"Genes Cells"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.4049\/jimmunol.180.5.3492","volume":"180","author":"Nishikawa","year":"2008","journal-title":"J. Immunol."},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310614"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1182\/blood.V74.4.1360.1360","volume":"74","author":"Yoshizaki","year":"1989","journal-title":"Blood"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1002\/art.10620"},{"key":"CIT0018","first-page":"851","volume":"53","author":"Sato","year":"1993","journal-title":"Cancer Res."},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/art.20944","volume":"52","author":"Yokota","year":"2005","journal-title":"Arthritis Rheum."},{"key":"CIT0020","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S0140-6736(08)60454-7","volume":"371","author":"Yokota","year":"2008","journal-title":"Lancet"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/art.20946","volume":"52","author":"de Benedetti","year":"2005","journal-title":"Arthritis Rheum."},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1084\/jem.20050473","volume":"201","author":"Pascual","year":"2005","journal-title":"J. Exp. Med."},{"key":"CIT0023","first-page":"79","volume":"3","author":"Lurati","year":"2005","journal-title":"Paed. Rheumatol. Online"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1136\/ard.2007.076034","volume":"67","author":"Lequerre","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"CIT0025","first-page":"390","volume":"31","author":"Petty","year":"2004","journal-title":"J. Rheumatol."},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000023439","volume":"52","author":"Zak","year":"1999","journal-title":"Horm. Res."},{"key":"CIT0027","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cyto.2009.05.002","volume":"47","author":"Nakajima","year":"2009","journal-title":"Cytokine"},{"key":"CIT0028","first-page":"907","volume":"35","author":"Immonen","year":"2008","journal-title":"J. Rheumatol."},{"key":"CIT0029","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1651-2227.2006.tb02414.x","volume":"95","author":"Cortis","year":"2005","journal-title":"Acta Pediatr. Suppl."},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/art.20198","volume":"50","author":"Grom","year":"2004","journal-title":"Arthritis Rheum."},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1055\/s-0029-1237386","volume":"221","author":"Janka","year":"2009","journal-title":"Klin. Padiatr."},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.iy.06.040188.002413","volume":"6","author":"Kishimoto","year":"1988","journal-title":"Annu. Rev. Immunol."},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.3109\/08830189809042997"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1146\/annurev.immunol.15.1.797","volume":"15","author":"Taga","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1096\/fasebj.10.14.9002549","volume":"10","author":"Leaman","year":"1996","journal-title":"FASEB J."},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1146\/annurev.immunol.15.1.797","volume":"15","author":"Taga","year":"1997","journal-title":"Ann. Rev. Immunol."},{"key":"CIT0037","first-page":"1403","volume":"24","author":"De Benedetti","year":"1997","journal-title":"J. Rheumatol."},{"key":"CIT0038","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.2741\/1690","volume":"10","author":"Romanovsky","year":"2005","journal-title":"Front. Biosci."},{"key":"CIT0039","first-page":"1670","volume":"28","author":"Pignatti","year":"2001","journal-title":"J. Rheumatol."},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/00002281-200309000-00011","volume":"15","author":"Grom","year":"2003","journal-title":"Curr. Opin Rheumatol."},{"key":"CIT0041","first-page":"865","volume":"28","author":"Ravelli","year":"2001","journal-title":"J. Rheumatol."},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.jhep.2006.03.003","volume":"44","author":"Bihl","year":"2006","journal-title":"J. Hepatol."},{"key":"CIT0043","first-page":"53","volume":"10","author":"Stabile","year":"2006","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"CIT0044","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1073\/pnas.88.11.4946","volume":"88","author":"Miller","year":"1991","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"CIT0045","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1089\/jir.1988.8.655","volume":"8","author":"Aulitzky","year":"1988","journal-title":"J. Interferon Res."},{"key":"CIT0046","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/jcp.21513","volume":"217","author":"Pucci","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"CIT0047","doi-asserted-by":"crossref","first-page":"36803","DOI":"10.1074\/jbc.M405297200","volume":"279","author":"Soriano","year":"2004","journal-title":"J. Biol. Chem."},{"key":"CIT0048","doi-asserted-by":"crossref","first-page":"8390","DOI":"10.1016\/S0021-9258(18)47576-X","volume":"262","author":"Semb","year":"1987","journal-title":"J. Biol. Chem."},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"R323","DOI":"10.1152\/ajpregu.1998.275.1.R323","volume":"275","author":"Romanovsky","year":"1998","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1074-7613(00)80119-3","volume":"11","author":"Takeuchi","year":"1999","journal-title":"Immunity"},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.physbeh.2006.05.016","volume":"89","author":"Harden","year":"2006","journal-title":"Physiol. Behav."},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1113\/jphysiol.2003.048140","volume":"551","author":"Oka","year":"2003","journal-title":"J. Physiol."},{"key":"CIT0053","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1089\/jir.2005.25.241","volume":"25","author":"Jones","year":"2005","journal-title":"J. Interferon Cytokine Res."},{"key":"CIT0054","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12032-007-0009-9","volume":"24","author":"Jacober","year":"2007","journal-title":"Med. Oncol."},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3109\/10428199609052418","volume":"20","author":"Veldhuis","year":"1996","journal-title":"Leuk. Lymphoma"},{"key":"CIT0056","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000243791","volume":"122","author":"Nemeth","year":"2009","journal-title":"Acta Haematol."},{"key":"CIT0057","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/BOR.0b013e3283295fec","volume":"21","author":"Mima","year":"2009","journal-title":"Curr. Opin Rheumatol."},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420945"},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/hyb.1991.10.137","volume":"10","author":"Novick","year":"1999","journal-title":"Hybridoma"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1002\/art.20303"},{"key":"CIT0061","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/1529-0131(199707)40:7<1202::AID-ART3>3.0.CO;2-R","volume":"40","author":"Giannini","year":"1997","journal-title":"Arthritis Rheum."}],"container-title":["Expert Review of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1586\/eci.10.41","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T07:46:50Z","timestamp":1711784810000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1586\/eci.10.41"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":61,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,1,10]]},"published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.1586\/eci.10.41"],"URL":"https:\/\/doi.org\/10.1586\/eci.10.41","relation":{},"ISSN":["1744-666X","1744-8409"],"issn-type":[{"value":"1744-666X","type":"print"},{"value":"1744-8409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}