{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:34:20Z","timestamp":1772127260832,"version":"3.50.1"},"reference-count":55,"publisher":"Informa UK Limited","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Review of Clinical Immunology"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1586\/eci.12.19","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T11:36:34Z","timestamp":1337600194000},"page":"319-331","source":"Crossref","is-referenced-by-count":50,"title":["Tofacitinib for the treatment of rheumatoid arthritis"],"prefix":"10.1586","volume":"8","author":[{"given":"Cristiano AF","family":"Zerbini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Barranjard Vannucci","family":"Lomonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2014,1,10]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum."},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nm1551","volume":"13","author":"Steinman","year":"2007","journal-title":"Nat. Med."},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.20070663","volume":"204","author":"Annunziato","year":"2007","journal-title":"J. Exp. Med."},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1084\/jem.20061775","volume":"203","author":"Sato","year":"2006","journal-title":"J. Exp. Med."},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/art.21749","volume":"54","author":"Kirkham","year":"2006","journal-title":"Arthritis Rheum."},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/ar1718","volume":"7","author":"Liepe","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1084\/jem.20061531","volume":"204","author":"Nadkarni","year":"2007","journal-title":"J. Exp. Med."},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1186\/ar2187"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137306"},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ncprheum0020","volume":"1","author":"McInnes","year":"2005","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1002\/art.21519"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1002\/art.10308"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/1529-0131(199809)41:9<1552::AID-ART5>3.0.CO;2-W","volume":"41","author":"Maini","year":"1998","journal-title":"Arthritis Rheum."},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1002\/art.20303"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.8197455","volume":"264","author":"Darnell","year":"1994","journal-title":"Science"},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-065X.2008.00754.x","volume":"228","author":"Ghoreschi","year":"2009","journal-title":"Immunol. Rev."},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.immunol.16.1.293","volume":"16","author":"Leonard","year":"1998","journal-title":"Annu. Rev. Immunol."},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nri2580","volume":"9","author":"Rochman","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"CIT0020","unstructured":"Bhan, Dari R, Kuriyan J. JAK\u2013STAT signaling. In:Handbook of Cell Signaling (1st Edition). Bradshaw R, Dennis E (Eds). Academic Press, NY, USA, 343\u2013347 (2003)."},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1126\/science.270.5237.797","volume":"270","author":"Russell","year":"1995","journal-title":"Science"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1126\/science.270.5237.800","volume":"270","author":"Nosaka","year":"1995","journal-title":"Science"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1126\/science.1087061","volume":"302","author":"Changelian","year":"2003","journal-title":"Science"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"8468","DOI":"10.1021\/jm1004286","volume":"53","author":"Flanagan","year":"2010","journal-title":"J. Med. Chem."},{"key":"CIT0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nbt1358","volume":"26","author":"Karaman","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1476-9255-7-41","volume":"7","author":"Meyer","year":"2010","journal-title":"J. Inflamm."},{"key":"CIT0027","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jmb.2010.05.020","volume":"400","author":"Chrencik","year":"2010","journal-title":"J. Mol. Biol."},{"key":"CIT0028","first-page":"36","volume":"11","author":"Krishnaswami","year":"2009","journal-title":"AAPS J."},{"key":"CIT0029","first-page":"PI-93","volume":"83","author":"Chow","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"CIT0030","first-page":"PI-92","volume":"83","author":"Chow","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"PII-86","DOI":"10.1038\/clpt.2008.224","volume":"85","author":"Chow","year":"2009","journal-title":"Clin. Pharmacol. Ther."},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/ar2365","volume":"10","author":"Milici","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.4049\/jimmunol.1003668","volume":"186","author":"Ghoreschi","year":"2011","journal-title":"J. Immunol."},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1097\/01.tp.0000184634.25042.ea","volume":"80","author":"Borie","year":"2005","journal-title":"Transplantation"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-6143.2003.00281.x"},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/00007890-197310000-00010","volume":"16","author":"Corry","year":"1973","journal-title":"Transplantation"},{"key":"CIT0037","first-page":"259","volume":"244","author":"Babany","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0038","first-page":"64","volume":"107","author":"Borie","year":"2002","journal-title":"J. Surg. Res."},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/01.TP.0000157117.30290.6F","volume":"79","author":"Borie","year":"2005","journal-title":"Transplantation"},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1002\/art.24567","volume":"60","author":"Kremer","year":"2009","journal-title":"Arthritis Rheum."},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/ard.2009.108159","volume":"69","author":"Coombs","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/art.33419","volume":"64","author":"Kremer","year":"2012","journal-title":"Arthritis Rheum."},{"key":"CIT0043","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/art.33383","volume":"64","author":"Fleischmann","year":"2012","journal-title":"Arthritis Rheum."},{"key":"CIT0044","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/acr.20494","volume":"63","author":"Tanaka","year":"2011","journal-title":"Arthritis Care Res. (Hoboken)"},{"key":"CIT0045","unstructured":"Fleischmann R, Kremer J, Cush Jet al.Phase 3 study of oral JAK inhibitor tasocitinib (CP-690,550) monotherapy in patients with active rheumatoid arthritis. Presented at:Annual Scientific Meeting of the American College of Rheumatology. Atlanta, GA, USA, 6\u201311 November 2010 (Abstract 4352)."},{"key":"CIT0046","first-page":"2592","volume":"63","author":"van der Heijde","year":"2011","journal-title":"Arthritis Rheum."},{"key":"CIT0047","first-page":"718","volume":"63","author":"Burmester","year":"2011","journal-title":"Arthritis Rheum."},{"key":"CIT0048","first-page":"1129","volume":"62","author":"Connell","year":"2010","journal-title":"Artrhtis Rheum."},{"key":"CIT0049","first-page":"2171","volume":"62","author":"Connell","year":"2010","journal-title":"Arthritis Rheum."},{"key":"CIT0050","first-page":"S152","volume":"63","author":"Wollenhaupt","year":"2011","journal-title":"Arthritis Rheum."},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.1002\/art.30191","volume":"63","author":"Cohen","year":"2011","journal-title":"Arthritis Rheum."},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1136\/ard.2010.139527","volume":"70","author":"van de Sande","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"CIT0053","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/ard.2010.130625","volume":"70","author":"Machado","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"CIT0054","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nrd3155","volume":"9","author":"Opar","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nri1226","volume":"3","author":"Shuai","year":"2003","journal-title":"Nat. Rev. Immunol."}],"container-title":["Expert Review of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1586\/eci.12.19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T23:36:35Z","timestamp":1561764995000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1586\/eci.12.19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":55,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,1,10]]},"published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1586\/eci.12.19"],"URL":"https:\/\/doi.org\/10.1586\/eci.12.19","relation":{},"ISSN":["1744-666X","1744-8409"],"issn-type":[{"value":"1744-666X","type":"print"},{"value":"1744-8409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}