{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T12:47:23Z","timestamp":1744289243119,"version":"3.38.0"},"reference-count":102,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Review of Anticancer Therapy"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1586\/era.10.193","type":"journal-article","created":{"date-parts":[[2011,3,21]],"date-time":"2011-03-21T11:14:11Z","timestamp":1300706051000},"page":"373-386","source":"Crossref","is-referenced-by-count":9,"title":["Development of targeted therapy for squamous cell carcinomas of the head and neck"],"prefix":"10.1586","volume":"11","author":[{"given":"Alberto","family":"Burgos-Tiburcio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgardo S","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belisario A","family":"Arango","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis E","family":"Raez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2014,1,10]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3322\/caac.20006","volume":"59","author":"Jemal","year":"2009","journal-title":"CA Cancer J. Clin."},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1200\/JCO.2003.01.504","volume":"21","author":"Mendelsohn","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/1040-8428(94)00144-I","volume":"19","author":"Salomon","year":"1995","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrm1962","volume":"7","author":"Citri","year":"2006","journal-title":"Nat. Rev. Mol. Biol."},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nrc1609","volume":"5","author":"Hynes","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/erc.0.0100001","volume":"10","author":"Normanno","year":"2003","journal-title":"Endocr. Relat. Cancer"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ccr.2005.03.003","volume":"7","author":"Li","year":"2005","journal-title":"Cancer Cell"},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"27595","DOI":"10.1016\/S0021-9258(18)47026-3","volume":"269","author":"Fan","year":"1994","journal-title":"J. Biol. Chem."},{"key":"CIT0009","first-page":"1311","volume":"1","author":"Goldstein","year":"1995","journal-title":"Clin. Cancer Res."},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00002371-199611000-00006","volume":"19","author":"Prewett","year":"1996","journal-title":"J. Immunother. Emphasis Tumor Immunol."},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/jnci\/89.5.341","volume":"89","author":"Mendelsohn","year":"1997","journal-title":"J. Natl Cancer Inst."},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.1999.14.451"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1200\/JCO.2000.18.4.904","volume":"18","author":"Baselga","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJMoa053422","volume":"354","author":"Bonner","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.4646"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1200\/JCO.2006.06.7447","volume":"25","author":"Vermorken","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1056\/NEJMoa0802656","volume":"359","author":"Vermorken","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.ijrobp.2003.08.035","volume":"58","author":"Milas","year":"2004","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1470-2045(09)70311-0","volume":"11","author":"Bonner","year":"2010","journal-title":"Lancet Oncol."},{"key":"CIT0020","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.ijrobp.2009.07.057","volume":"75","author":"Kies","year":"2009","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3342\/ceo.2009.2.4.159","volume":"2","author":"Lefebvre","year":"2009","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"CIT0022","doi-asserted-by":"crossref","unstructured":"Lefebvre JL, Pointreau Y, Rolland Fet al.Groupe Oncologie Radiotherapie Tete Et Cou (GORTEC). Sequential chemoradiotherapy (SCRT) for larynx preservation (LP), preliminary results of the randomized Phase II TREMPLIN study. Presented at:American Society of Clinical Oncology. Orlando, FL, USA, 29 May\u20132 June 2009.","DOI":"10.1200\/jco.2009.27.15_suppl.6010"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1200\/JCO.2005.07.119","volume":"23","author":"Baselga","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"8418","DOI":"10.1158\/1078-0432.CCR-05-1247","volume":"11","author":"Cohen","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"CIT0025","unstructured":"Stewart JS, Cohen E, Licitra Let al.A Phase III randomized parallel-group study of gefitinib (IRESSA) versus methotrexate (IMEX) in patients with recurrent squamous cell carcinoma of the head and neck. Presented at:98th Annual Meeting of the American Association for Cancer Research. Los Angeles, CA, USA, 14\u201318 April 2007."},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"507s","DOI":"10.1200\/jco.2005.23.16_suppl.5531","volume":"23","author":"Wheeler","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"CIT0027","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1200\/JCO.2004.06.075","volume":"22","author":"Soulieres","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1200\/JCO.2003.10.051","volume":"21","author":"Ezra","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"CIT0029","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1200\/jco.2009.27.15_suppl.6011","volume":"27","author":"Argiris, Ghebremichael","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1200\/JCO.2008.20.8231","volume":"27","author":"Simon","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0022-3565(24)35162-6","volume":"291","author":"Pollack","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1200\/JCO.2001.19.13.3267","volume":"19","author":"Hidalgo","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1200\/JCO.2008.17.5349","volume":"27","author":"Harrington","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000046610","volume":"106","author":"Ferrara","year":"2001","journal-title":"Acta Haematol."},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1200\/jco.2008.26.15_suppl.6072","volume":"26","author":"Kies","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1200\/jco.2008.26.15_suppl.6069","volume":"26","author":"Feinstein","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"CIT0037","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.1200\/jco.2008.26.15_suppl.6064","volume":"26","author":"Choong","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1319"},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0093-7754(01)90211-8","volume":"28","author":"Hockel","year":"2001","journal-title":"Semin. Oncol."},{"key":"CIT0040","first-page":"3374","volume":"59","author":"Gorski","year":"1999","journal-title":"Cancer Res."},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1368-8375(99)00052-4","volume":"36","author":"Shemirani","year":"2000","journal-title":"Oral Oncol."},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s004059900208","volume":"257","author":"Riedel","year":"2000","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"CIT0043","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1200\/JCO.2000.18.10.2046","volume":"18","author":"Smith","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"CIT0044","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/jnci\/82.1.4","volume":"82","author":"Folkman","year":"1990","journal-title":"J. Natl Cancer Inst."},{"key":"CIT0045","first-page":"1957","volume":"9","author":"Wachsberger","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"CIT0046","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/hed.20326","volume":"28","author":"Lothaire","year":"2006","journal-title":"Head Neck"},{"key":"CIT0047","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1023\/A:1006764100867","volume":"18","author":"O-Charoenrat","year":"2000","journal-title":"Clin. Exp. Metastasis"},{"key":"CIT0048","doi-asserted-by":"crossref","first-page":"501s","DOI":"10.1200\/JCO.2005.95.028","volume":"23","author":"Vokes","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S1470-2045(09)70002-6","volume":"10","author":"Cohen","year":"2009","journal-title":"Lancet Oncol."},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1200\/jco.2008.26.15_suppl.6069","volume":"26","author":"Feinstein","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1002\/cncr.22208","volume":"107","author":"Ceppi","year":"2006","journal-title":"Cancer"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"302s","DOI":"10.1200\/jco.2007.25.18_suppl.6068","volume":"25","author":"Savvides","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"CIT0053","doi-asserted-by":"crossref","first-page":"302s","DOI":"10.1200\/jco.2007.25.18_suppl.6034","volume":"25","author":"Choong","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.1706"},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"332s","DOI":"10.1200\/JCO.2007.14.7249","volume":"26","author":"Choong","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"CIT0056","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.1200\/JCO.2009.21.2779","volume":"27","author":"Machiels","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"CIT0057","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.1200\/jco.2009.27.15_suppl.6023","volume":"27","author":"Saura","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.2174\/138920106779116865"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.01.038"},{"key":"CIT0060","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.critrevonc.2005.12.001","volume":"58","author":"Scagliotti","year":"2006","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"CIT0061","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1634\/theoncologist.7-1-9","volume":"7","author":"Adams","year":"2002","journal-title":"Oncologist"},{"key":"CIT0062","first-page":"251","volume":"35","author":"Lun","year":"2005","journal-title":"Ann. Clin. Lab. Sci."},{"key":"CIT0063","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.ijrobp.2005.05.007","volume":"63","author":"Van Waes","year":"2005","journal-title":"Int. J. Rad. Oncol. Biol. Phys."},{"key":"CIT0064","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-7-221","volume":"7","author":"Hayslip","year":"2007","journal-title":"BMC Cancer"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31815ba7d0"},{"key":"CIT0066","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/COC.0b013e31805c142f","volume":"31","author":"Cohen","year":"2008","journal-title":"Am. J. Clin. Oncol."},{"key":"CIT0067","doi-asserted-by":"crossref","first-page":"S323","DOI":"10.1200\/jco.2008.26.15_suppl.6028","volume":"26","author":"Kubicek","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"CIT0068","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1158\/0008-5472.CAN-06-2162","volume":"67","author":"Lorch","year":"2007","journal-title":"Cancer Res."},{"key":"CIT0069","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/sj.bjc.6605043","volume":"100","author":"Dudek","year":"2009","journal-title":"Br. J. Cancer"},{"key":"CIT0070","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/annonc\/mdp390","volume":"21","author":"Chung","year":"2010","journal-title":"Ann. Oncol."},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2040"},{"key":"CIT0072","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.canlet.2006.08.004","volume":"248","author":"Slomainy","year":"2007","journal-title":"Cancer Lett."},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.209.217"},{"key":"CIT0074","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1158\/0008-5472.CAN-06-2000","volume":"67","author":"Allen","year":"2007","journal-title":"Cancer Res."},{"key":"CIT0075","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1002\/ijc.22221","volume":"119","author":"Desbois-Mouthon","year":"2006","journal-title":"Int. J. Cancer"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0247"},{"key":"CIT0077","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/sj.neo.7900242","volume":"4","author":"Wan","year":"2002","journal-title":"Neoplasia"},{"key":"CIT0078","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1179\/016164105X18151","volume":"27","author":"Yin","year":"2005","journal-title":"Neurol. Res."},{"key":"CIT0079","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1200\/JCO.2007.15.9319","volume":"26","author":"Lacy","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"CIT0080","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.1158\/1078-0432.CCR-07-1118","volume":"13","author":"Haluska","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"CIT0081","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.1200\/jco.2007.25.18_suppl.7506","volume":"25","author":"Karp","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"CIT0082","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2008.19.9331","volume":"27","author":"Karp","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"CIT0083","first-page":"388","volume":"6","author":"Postel-Vinay","year":"2008","journal-title":"Proc. Eur. J. Cancer"},{"key":"CIT0084","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1200\/JCO.2006.08.8146","volume":"25","author":"Higano","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"CIT0085","first-page":"84","volume":"12","author":"Rothenberg","year":"2007","journal-title":"Mol. Target Cancer Ther."},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.8898"},{"key":"CIT0087","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1200\/jco.2008.26.15_suppl.3583","volume":"26","author":"Sarantopoulus","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"CIT0088","first-page":"1715","volume":"5","author":"Clayman","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"CIT0089","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1200\/JCO.1998.16.6.2221","volume":"16","author":"Clayman","year":"1998","journal-title":"J. Clin. Oncol."},{"key":"CIT0090","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1200\/JCO.2006.08.2826","volume":"25","author":"Nemunaitis","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"CIT0091","first-page":"445a","volume":"18","author":"Goodwin","year":"1999","journal-title":"Proc. Am. Soc. Clin. Oncol."},{"key":"CIT0092","first-page":"431a","volume":"18","author":"Bier-Laning","year":"1999","journal-title":"Proc. Am. Soc. Clin. Oncol."},{"key":"CIT0093","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/archoto.2009.122","volume":"135","author":"Yoo","year":"2009","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"CIT0094","first-page":"798","volume":"6","author":"Ganly","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"CIT0095","first-page":"6359","volume":"60","author":"Nemunaitis","year":"2000","journal-title":"Cancer Res."},{"key":"CIT0096","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.274.5286.373","volume":"274","author":"Bischoff","year":"1996","journal-title":"Science"},{"key":"CIT0097","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/78638","volume":"6","author":"Khuri","year":"2000","journal-title":"Nat. Med."},{"key":"CIT0098","doi-asserted-by":"crossref","DOI":"10.1200\/jco.2009.27.15_suppl.6003","volume":"27","author":"Gillison","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"CIT0099","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1200\/JCO.2009.22.4170","volume":"28","author":"Perrone","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"CIT0100","first-page":"1","volume":"7","author":"Holgersson","year":"2010","journal-title":"Cancer Genomics Proteomics"},{"key":"CIT0101","first-page":"1","volume":"14","author":"Silva","year":"2010","journal-title":"J. Laryngol. Otol."},{"key":"CIT0102","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1600-0463.2010.02624.x","volume":"118","author":"Lajer","year":"2010","journal-title":"APMIS"}],"container-title":["Expert Review of Anticancer Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1586\/era.10.193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T16:37:46Z","timestamp":1741106266000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1586\/era.10.193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":102,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,1,10]]},"published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1586\/era.10.193"],"URL":"https:\/\/doi.org\/10.1586\/era.10.193","relation":{},"ISSN":["1473-7140","1744-8328"],"issn-type":[{"type":"print","value":"1473-7140"},{"type":"electronic","value":"1744-8328"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}