{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:42:57Z","timestamp":1773283377158,"version":"3.50.1"},"reference-count":98,"publisher":"Informa UK Limited","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Review of Anti-infective Therapy"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1586\/eri.11.107","type":"journal-article","created":{"date-parts":[[2011,11,7]],"date-time":"2011-11-07T08:15:06Z","timestamp":1320653706000},"page":"909-922","source":"Crossref","is-referenced-by-count":41,"title":["Will new antimicrobials overcome resistance among Gram-negatives?"],"prefix":"10.1586","volume":"9","author":[{"given":"Matteo","family":"Bassetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ginocchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Mikulska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Taramasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Roberto","family":"Giacobbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2014,1,10]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1086\/655996","volume":"31","author":"Kallen","year":"2010","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"pii: 19045","DOI":"10.2807\/ese.13.47.19045-en","volume":"13","author":"Souli","year":"2008","journal-title":"Euro Surveill."},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1469-0691.2007.01943.x","volume":"14","author":"Rodloff","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"S345","DOI":"10.1097\/CCM.0b013e3181e6cbc5","volume":"38","author":"Maragakis","year":"2010","journal-title":"Crit. Care Med"},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1086\/605539","volume":"49","author":"Peterson","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01169-07"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkq415","volume":"66","author":"Rogers","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.clinthera.2010.04.003","volume":"32","author":"Koomanachai","year":"2010","journal-title":"Clin. Ther."},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1086\/524891"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1086\/652237"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2010.06.001"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1086\/648078","volume":"49","author":"Munoz-Price","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.phytochem.2005.02.030","volume":"66","author":"Brakhage","year":"2005","journal-title":"Phytochemistry"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4103\/0974-777X.68531","volume":"2","author":"Rawat","year":"2010","journal-title":"J. Glob Infect. Dis."},{"key":"CIT0015","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S0924-8579(10)70004-2","volume":"36","author":"Walsh","year":"2010","journal-title":"Int. J. Antimicrob. Agents."},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm318"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.6.1211"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1980.0049"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00219-10"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70054-4"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70143-2"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq520"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.drup.2010.05.002","volume":"13","author":"Falagas","year":"2010","journal-title":"Drug Resist. Update"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1056\/NEJMra070741","volume":"358","author":"Munoz-Price","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00040-09"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.02.009"},{"key":"CIT0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/mdr.2006.9990","volume":"13","author":"Keeney","year":"2007","journal-title":"Microb. Drug Resist."},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2174\/1568026033452537","volume":"3","author":"Drlica","year":"2003","journal-title":"Curr. Top. Med. Chem."},{"key":"CIT0029","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11373-007-9194-y","volume":"15","author":"Shakil","year":"2008","journal-title":"J. Biomed. Sci."},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1517\/13543776.2010.506189","volume":"20","author":"Dozzo","year":"2008","journal-title":"Expert Opin. Ther. Pat."},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1074\/jbc.M411325200","volume":"280","author":"Eschenburg","year":"2005","journal-title":"J. Biol. Chem."},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1128\/AAC.44.3.647-650.2000","volume":"44","author":"Kobayashi","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.17.3.285"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1086\/526527","volume":"46","author":"Noel","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1517\/14656560903048967","volume":"10","author":"El Solh","year":"2009","journal-title":"Expert Opin. Pharmacother."},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1517\/14656561003777026","volume":"11","author":"Nannini","year":"2010","journal-title":"Expert Opin. Pharmacother."},{"key":"CIT0037","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1128\/AAC.01452-08","volume":"53","author":"Vidaillac","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0038","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1086\/655827","volume":"51","author":"Corey","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm150"},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1128\/AAC.01787-10","volume":"55","author":"Karlowsky","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1128\/AAC.01104-09","volume":"54","author":"Moya","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0042","unstructured":"Brown NP, Pillar CM, Sahm DF, Alluru V, Grover P, Ge Y. Activity profile of CXA-101 and CXA-101\/tazobactam against target Gram-positive and Gram-negative pathogens. Presented at:49th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA, 12\u201315 September 2009."},{"key":"CIT0043","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1128\/AAC.01753-09","volume":"54","author":"Ge","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0044","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diagmicrobio.2011.02.004","volume":"70","author":"Titelman","year":"2011","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"CIT0045","unstructured":"Clinical and Laboratory Standards Institute.Performance Standards for Antimicrobial Susceptibility Testing; Twentieth Informational Supplement (June 2010 Update) M100-S20-U. CLSI, Wayne, PA, USA (2010)."},{"key":"CIT0046","doi-asserted-by":"crossref","first-page":"564","DOI":"10.2174\/092986709787458498","volume":"16","author":"Bassetti","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"CIT0047","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.2146\/ajhp090672","volume":"67","author":"Chahine","year":"2010","journal-title":"Am. J. Health Syst. Pharm."},{"key":"CIT0048","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s10096-010-0974-3","volume":"29","author":"Betriu","year":"2010","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1128\/AAC.01004-09","volume":"54","author":"Queenan","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1097\/CCM.0b013e3181691b99","volume":"36","author":"Chastre","year":"2008","journal-title":"Crit. Care Med."},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1159\/000319952","volume":"56","author":"Jia","year":"2010","journal-title":"Chemotherapy"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s10156-010-0112-2","volume":"17","author":"Gomi","year":"2011","journal-title":"J. Infect. Chemother."},{"key":"CIT0053","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.2169\/internalmedicine.49.3360","volume":"49","author":"Fukushima","year":"2010","journal-title":"Intern. Med."},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-007-0507-X"},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1128\/AAC.00413-08","volume":"52","author":"Koga","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0056","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/jac\/dkp187","volume":"64","author":"Livermore","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"CIT0057","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2165\/00003495-200363090-00005","volume":"63","author":"Goa","year":"2003","journal-title":"Drugs"},{"key":"CIT0058","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ja.2008.101","volume":"61","author":"Yoshida","year":"2008","journal-title":"Jpn J. Antibiot."},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/jac\/dkp163","volume":"64","author":"Morrissey","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"CIT0060","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/jac\/dkr013","volume":"66","author":"Russo","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"CIT0061","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1128\/AAC.01525-09","volume":"54","author":"Page","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0062","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ijmm.2010.04.005","volume":"300","author":"Pfeifer","year":"2010","journal-title":"Int. J. Med. Microbiol."},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.12.4589-4596.2004"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.2165\/11318430-000000000-00000"},{"key":"CIT0065","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1128\/AAC.01549-08","volume":"53","author":"Petersen","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1080\/10408410902733979"},{"key":"CIT0067","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/jac\/dkp435","volume":"65","author":"Ruzin","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"CIT0068","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1128\/AAC.00085-08","volume":"53","author":"Paukner","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.8.2615-2618.2003"},{"key":"CIT0070","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1128\/AAC.48.11.4482-4484.2004","volume":"48","author":"Bowker","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0071","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1128\/AAC.01722-10","volume":"55","author":"Lagac\u00e9-Wiens","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0072","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1586\/eri.10.173","volume":"9","author":"Curcio","year":"2011","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq161"},{"key":"CIT0074","unstructured":"Melchers R, Mavridou E, Van Mil A, Motyl MR, Mouton JW.In vitroactivity of imipenem alone and in combination with MK-7655: a new \u03b2-lactamase inhibitor. Presented at:50th Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston, MA, USA, 12\u201315 September 2010."},{"key":"CIT0075","unstructured":"Mavridou E, Melchers R, Van Mil A, Mangin E, Mouton JW. Pharmacodynamics of imipenem in combination with MK-7655, a \u03b2-lactamase inhibitor, in the neutropenic mouse thigh model. Presented at:50th Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston, MA, USA, 12\u201315 September 2010."},{"key":"CIT0076","unstructured":"Hirsch EB, Ledesma KR, Chang KT, Motyl MR, Tam VH.In vitroactivity of MK-7655 in combination with imipenem (IPM) against carbapenem resistant Gram-negative bacteria. Presented at:50th Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston, MA, USA, 12\u201315 September 2010."},{"key":"CIT0077","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ijantimicag.2008.09.003","volume":"33","author":"Maltezou","year":"2009","journal-title":"Int. J. Antimicrob. Agents."},{"key":"CIT0078","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/jac\/dkq310","volume":"65","author":"Livermore","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"CIT0079","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1128\/AAC.01370-10","volume":"55","author":"Page","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01397-09"},{"key":"CIT0081","unstructured":"Sutcliffe J, Ronn M, Leighton A, Sprenger C. Phase 1 single ascending dose study of a broad-spectrum fluorocycline, TP-434. Presented at:50th Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston, MA, USA, 12\u201315 September 2010."},{"key":"CIT0082","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1086\/655988","volume":"31","author":"Talbot","year":"2010","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"CIT0083","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/jac\/dkq408","volume":"66","author":"Livermore","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq459"},{"key":"CIT0085","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1093\/jac\/dkq278","volume":"65","author":"Landman","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"CIT0086","unstructured":"Sader HS, Rhomberg PR, Jones RN. Antimicrobial activity of a novel polymyxin analog (CB-182,804) tested against clinical strains of Gram-negative bacilli, including colistin-resistant organisms. Presented at:50th Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston, MA, USA, 12\u201315 September 2010."},{"key":"CIT0087","unstructured":"Opperman TJ, Houseweart C, Williams JD, Peet NP, Moir DT, Bowlin TL. The mechanism of antibacterial action of novel bis-indole antibiotics. Presented at:50th Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston, MA, USA, 12\u201315 September 2010."},{"key":"CIT0088","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1128\/AAC.00484-10","volume":"54","author":"Butler","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0089","unstructured":"Hernandez V, Akama T, Alley Met al.Discovery and mechanism of action of AN3365: a novel boron containing antibacterial agent in clinical development for Gram-negative infections. Presented at:50th Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston, MA, USA, 12\u201315 September 2010."},{"key":"CIT0090","unstructured":"Biedenbach DJ, Mendes RE, Alley MRK, Sader HS, Jones R. Potency and spectrum of activity of AN3365, a novel boron-containing protein synthesis inhibitor, tested against non-fermentative Gram-negative bacilli. Presented at:50th Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston, MA, USA, 12\u201315 September 2010."},{"key":"CIT0091","unstructured":"Bouchillon S, Hoban D, Hackel M, Butler D, Demarsch P, Alley D.In vitroactivities of AN3365: a novel boron containing protein synthesis inhibitor and other antimicrobial agents against anaerobes andNeisseria gonorrhoeae.Presented at:50th Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston, MA, USA, 12\u201315 September 2010."},{"key":"CIT0092","unstructured":"Freund YR, Liu L, Alley MRKet al.Murine pharmacokinetics andin vivoGram-negative activity of AN3365: a novel boron-containing protein synthesis inhibitor. Presented at:50th Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston, MA, USA, 12\u201315 September 2010."},{"key":"CIT0093","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.bmcl.2010.12.111","volume":"21","author":"Mansoor","year":"2011","journal-title":"Bioorg Med. Chem. Lett."},{"key":"CIT0094","unstructured":"Ippolito J, Wang D, Chen Set al.Novel antibiotic classes to treat Gram-negative infections. Presented at:49th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA, 12\u201315 September 2009."},{"key":"CIT0095","doi-asserted-by":"crossref","first-page":"e1001067","DOI":"10.1371\/journal.ppat.1001067","volume":"6","author":"Peters","year":"2010","journal-title":"PloS Pathog."},{"key":"CIT0096","unstructured":"Vila-Farres X, Garcia-De La Maria C, Giralt E, Vila J.In vitroactivity of mastoparan against colistin-susceptible and resistantAcinetobacter baumannii. Presented at:50th Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston, MA, USA, 12\u201315 September 2010."},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00815-08"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2009.08.006"}],"container-title":["Expert Review of Anti-infective Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1586\/eri.11.107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T02:50:40Z","timestamp":1639536640000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1586\/eri.11.107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":98,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,1,10]]},"published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1586\/eri.11.107"],"URL":"https:\/\/doi.org\/10.1586\/eri.11.107","relation":{},"ISSN":["1478-7210","1744-8336"],"issn-type":[{"value":"1478-7210","type":"print"},{"value":"1744-8336","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}