{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:07:48Z","timestamp":1791148068430,"version":"4.1.0"},"reference-count":67,"publisher":"Informa UK Limited","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Review of Anti-infective Therapy"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1586\/eri.12.25","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T10:11:02Z","timestamp":1334830262000},"page":"459-473","source":"Crossref","is-referenced-by-count":183,"title":["Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin"],"prefix":"10.1586","volume":"10","author":[{"given":"George G","family":"Zhanel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D","family":"Lawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl","family":"Zelenitsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Findlay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Schweizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Walkty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Rubinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred S","family":"Gin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl J","family":"Hoban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A","family":"Karlowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2014,1,10]]},"reference":[{"issue":"10","key":"CIT0001","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1517\/13543776.2010.506189","volume":"20","author":"Dozzo","year":"2010","journal-title":"Expert Opin. Ther. Pat."},{"key":"CIT0002","unstructured":"Gilbert DN. Aminoglycosides. In:Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases. Mandell GL, Douglas RG, Bennett JE, Dolin R (Eds). Elsevier\/Churchill Livingstone, NY, USA, 328\u2013356 (2005)."},{"issue":"5","key":"CIT0003","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2710.1987.tb00539.x","volume":"12","author":"Mathews","year":"1987","journal-title":"J. Clin. Pharm. Ther."},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1111\/imj.2011.41.issue-6"},{"issue":"1","key":"CIT0005","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ccc.2010.11.006","volume":"27","author":"Craig","year":"2011","journal-title":"Crit. Care Clin."},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp256"},{"issue":"8","key":"CIT0007","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1086\/652237","volume":"50","year":"2010","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"CIT0008","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1128\/MMBR.57.1.138-163.1993","volume":"57","author":"Shaw","year":"1993","journal-title":"Microbiol. Rev."},{"issue":"2","key":"CIT0009","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1473-3099(05)70086-4","volume":"5","author":"Norrby","year":"2005","journal-title":"Lancet Infect. Dis."},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/ja.2011.44","volume":"64","author":"Butler","year":"2011","journal-title":"J. Antibiot. (Tokyo)"},{"issue":"11","key":"CIT0011","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1128\/AAC.00572-10","volume":"54","author":"Aggen","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"CIT0012","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.mib.2010.09.004","volume":"13","author":"Armstrong","year":"2010","journal-title":"Curr. Opin. Microbiol."},{"issue":"2","key":"CIT0013","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00253-005-0279-0","volume":"70","author":"Jana","year":"2006","journal-title":"Appl. Micro biol. Biotechnol."},{"issue":"1","key":"CIT0014","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11373-007-9194-y","volume":"15","author":"Shakil","year":"2008","journal-title":"J. Biomed. Sci."},{"issue":"11","key":"CIT0015","doi-asserted-by":"crossref","first-page":"551","DOI":"10.7164\/antibiotics.23.551","volume":"23","author":"Weinstein","year":"1970","journal-title":"J. Antibiot. (Tokyo)"},{"issue":"6","key":"CIT0016","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1128\/AAC.23.6.835","volume":"23","author":"Bryan","year":"1983","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"CIT0017","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1128\/MMBR.51.4.439-457.1987","volume":"51","author":"Taber","year":"1987","journal-title":"Microbiol. Rev."},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.38.100184.001321"},{"issue":"6","key":"CIT0019","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1128\/AAC.29.6.1079","volume":"29","author":"Martin","year":"1986","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"CIT0020","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1128\/mr.51.3.341-350.1987","volume":"51","author":"Davis","year":"1987","journal-title":"Micro biol. Rev."},{"issue":"3","key":"CIT0021","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/jac\/29.3.235","volume":"29","author":"Hancock","year":"1992","journal-title":"J. Antimicrob. Chemother."},{"issue":"6","key":"CIT0022","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S1367-5931(99)00028-9","volume":"3","author":"Walter","year":"1999","journal-title":"Curr. Opin. Chem. Biol."},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1002\/j.1460-2075.1991.tb07863.x","volume":"10","author":"Woodcock","year":"1991","journal-title":"EMBO J."},{"issue":"1","key":"CIT0024","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0026-895X(25)14722-6","volume":"1","author":"Davies","year":"1965","journal-title":"Mol. Pharma col."},{"key":"CIT0025","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0092-8674(77)90147-7","volume":"10","author":"Edelmann","year":"1977","journal-title":"Cell"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1093\/emboj\/18.11.3133","volume":"18","author":"Recht","year":"1999","journal-title":"EMBO J."},{"issue":"5","key":"CIT0027","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1006\/jmbi.2000.4420","volume":"306","author":"Lynch","year":"2001","journal-title":"J. Mol. Bio l."},{"key":"CIT0028","doi-asserted-by":"crossref","unstructured":"Shakya T, Wright GD. Mechanisms of aminoglycoside antibiotic resistance. In:Aminoglycos ide Antibiotics.Arya, DP (Ed.). John Wiley & Sons, Inc., Hoboken, NJ, USA, 11 9\u201314 0 (2007).","DOI":"10.1002\/9780470149676.ch3"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1086\/338782"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/j.1460-2075.1989.tb03494.x","volume":"8","author":"De Stasio","year":"1989","journal-title":"EMBO J."},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1086\/515328","volume":"177","author":"Prammananan","year":"1998","journal-title":"J. Infect. Dis."},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0923-2508(96)80205-1","volume":"147","author":"Sander","year":"1996","journal-title":"Res. Microbiol."},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1093\/nar\/gkp575","volume":"37","author":"Savic","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"CIT0034","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1128\/AAC.49.7.2949-2953.2005","volume":"49","author":"Galimand","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"CIT0035","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1128\/AAC.00748-08","volume":"53","author":"Wu","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"7868","DOI":"10.1128\/jb.174.23.7868-7872.1992","volume":"174","author":"Kojic","year":"1992","journal-title":"J. Bacteriol."},{"issue":"4","key":"CIT0037","first-page":"915","volume":"133","author":"Skeggs","year":"1987","journal-title":"J. Gen. Microbiol."},{"issue":"12","key":"CIT0038","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1128\/AAC.00926-07","volume":"51","author":"Wachino","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/S0140-6736(03)14959-8","volume":"362","author":"Yokoyama","year":"2003","journal-title":"Lancet"},{"issue":"6","key":"CIT0040","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3201\/eid1106.040924","volume":"11","author":"Yamane","year":"2005","journal-title":"Emerg. Infect. Dis."},{"issue":"1","key":"CIT0041","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0022-2836(90)90309-A","volume":"212","author":"De Stasio","year":"1990","journal-title":"J. Mol. Biol."},{"issue":"5","key":"CIT0042","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1128\/AAC.42.5.1295","volume":"42","author":"Alangaden","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"CIT0043","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1128\/AAC.15.1.7","volume":"15","author":"Bryan","year":"1979","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"CIT0044","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/jac\/dki171","volume":"56","author":"Poole","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"issue":"1","key":"CIT0045","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1469-0691.2004.00763.x","volume":"10","author":"Poole","year":"2004","journal-title":"Clin. Microbiol. Infect."},{"issue":"10","key":"CIT0046","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1128\/AAC.47.10.3202-3207.2003","volume":"47","author":"Sobel","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0047","unstructured":"Georgescu C, Martin D-A, Bratu S, Quale J, Landman D. Activity of ACHN-490, a novel neoglycoside antibiotic, against contemporary Gram-negative clinical isolates from Brooklyn, N Y hospitals. Presented at:49th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA, 12\u201315 September 2009."},{"issue":"6","key":"CIT0048","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drup.2010.08.003","volume":"13","author":"Ramirez","year":"2010","journal-title":"Drug Resist. Updat."},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1038\/219288a0"},{"issue":"1","key":"CIT0050","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1128\/MMBR.40.1.168-189.1976","volume":"40","author":"Novick","year":"1976","journal-title":"Bacteriol. Rev."},{"issue":"3","key":"CIT0051","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1128\/MMBR.47.3.361-409.1983","volume":"47","author":"Foster","year":"1983","journal-title":"Microbiol. Rev."},{"key":"CIT0052","unstructured":"Biedenbach DJ, Jones RN, Armstrong E S, Aggen JB, Miller GH. Activity of ACHN-490 against complicated urinary tract infection (cUTI) pathogens from the United States and Europe.Presented at: 49th Interscience Conference on Antimicrobial Agents and Chemotherapy.San Francisco, CA, USA, 12\u201315 September 2009."},{"issue":"10","key":"CIT0053","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1093\/jac\/dkq278","volume":"65","author":"Landman","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"issue":"2","key":"CIT0054","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/jac\/dkq459","volume":"66","author":"Landman","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"CIT0056","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ijantimicag.2011.05.016","volume":"38","author":"Tenover","year":"2011","journal-title":"Int. J. Antimicrob. Agents,"},{"issue":"10","key":"CIT0057","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1128\/AAC.00556-09","volume":"53","author":"Endimiani","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"CIT0062","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/jac\/dkq408","volume":"66","author":"Livermore","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"issue":"5","key":"CIT0063","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1128\/AAC.01390-10","volume":"55","author":"Pankuch","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"CIT0065","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1128\/AAC.00862-10","volume":"55","author":"Reyes","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"CIT0066","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/jac\/dkn547","volume":"63","author":"Endimiani","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"issue":"4","key":"CIT0067","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.diagmicrobio.2005.04.004","volume":"52","author":"Hirakata","year":"2005","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"CIT0068","unstructured":"Bauer LA. The aminoglycoside antibiotics. In:Applied Clinical Pharmacokinetics. McGraw-Hill Medical, NY, USA (2008)."},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00624-11"},{"issue":"3","key":"CIT0075","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/j.1875-9114.1997.tb03063.x","volume":"17","author":"Karlowsky","year":"1997","journal-title":"Pharmacotherapy"},{"issue":"5","key":"CIT0076","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1128\/AAC.01350-09","volume":"54","author":"Lin","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"CIT0077","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/infdis\/135.Supplement_2.S316","volume":"134","author":"Lode","year":"1976","journal-title":"J. Infect. Dis."},{"issue":"4","key":"CIT0078","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1128\/AAC.8.4.396","volume":"8","author":"Lode","year":"1975","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Expert Review of Anti-infective Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1586\/eri.12.25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T01:56:00Z","timestamp":1742954160000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1586\/eri.12.25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":67,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,1,10]]},"published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1586\/eri.12.25"],"URL":"https:\/\/doi.org\/10.1586\/eri.12.25","relation":{},"ISSN":["1478-7210","1744-8336"],"issn-type":[{"value":"1478-7210","type":"print"},{"value":"1744-8336","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}