{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:11:31Z","timestamp":1773681091847,"version":"3.50.1"},"reference-count":234,"publisher":"Informa UK Limited","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Review of Neurotherapeutics"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1586\/ern.09.116","type":"journal-article","created":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T17:36:00Z","timestamp":1259688960000},"page":"1815-1836","source":"Crossref","is-referenced-by-count":29,"title":["Molecularly targeted therapies for malignant glioma: rationale for combinatorial strategies"],"prefix":"10.1586","volume":"9","author":[{"given":"Nikhil G","family":"Thaker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian F","family":"Pollack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2014,1,9]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850901)56:5<1106::AID-CNCR2820560525>3.0.CO;2-2"},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nmat1952","volume":"6","author":"Iorns","year":"2007","journal-title":"Nature"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164382"},{"key":"CIT0004","first-page":"430","volume":"3","author":"Rich","year":"2004","journal-title":"Nature"},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1200\/JCO.2005.04.0402","volume":"24","author":"Wang","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature07385","volume":"455","author":"McLendon","year":"2008","journal-title":"Nature"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s11910-004-0042-4","volume":"4","author":"Wen","year":"2004","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"CIT0008","unstructured":"Kleihues P, Cavanee W.World Health Organization Classification of Tumors: Tumors of the Nervous System: Pathology and Genetics. IRAC Press, Lyon, France (2000)."},{"key":"CIT0009","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1566524033361609","volume":"3","author":"Konopka","year":"2003","journal-title":"Curr. Mol. Med."},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11912-006-0011-y","volume":"8","author":"Kesari","year":"2006","journal-title":"Curr. Oncol. Rep."},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/ncponc0820","volume":"4","author":"Collins","year":"2007","journal-title":"Nat. Clin. Pract. Oncol."},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1586\/14737140.6.7.1087","volume":"6","author":"Sathornsumetree","year":"2006","journal-title":"Expert Rev. Anticancer Ther."},{"key":"CIT0013","doi-asserted-by":"crossref","unstructured":"Pollack IF. Molecularly targeted therapies for childhood gliomas. In:Molecularly Targeted Therapy for Childhood Cancer. Houghton P (Ed.). Springer, NY, USA (2009).","DOI":"10.1007\/978-0-387-69062-9_12"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/cncr.22741","volume":"110","author":"Sathornsumetree","year":"2007","journal-title":"Cancer"},{"key":"CIT0015","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1227\/01.NEU.0000065135.28143.39","volume":"52","author":"Kapoor","year":"2003","journal-title":"Neurosurgery"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"16755","DOI":"10.1016\/S0021-9258(18)55365-5","volume":"266","author":"Nister","year":"1991","journal-title":"J. Biol. Chem."},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198906000-00001"},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/jnr.490270429","volume":"27","author":"Gross","year":"1990","journal-title":"J. Neurosci. Res."},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1038\/359845a0"},{"key":"CIT0020","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.4049\/jimmunol.148.5.1404","volume":"148","author":"Constam","year":"1992","journal-title":"J. Immunol."},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000520)89:3<251::AID-IJC7>3.0.CO;2-5"},{"key":"CIT0022","first-page":"2164","volume":"51","author":"Ekstrand","year":"1991","journal-title":"Cancer Res."},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/313144a0","volume":"313","author":"Libermann","year":"1985","journal-title":"Nature"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.7.2965"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.0705"},{"key":"CIT0026","first-page":"5749","volume":"62","author":"Wakeling","year":"2002","journal-title":"Cancer Res."},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.1.110"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.03.100"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.038"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.07.215"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040938"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1200\/JCO.2004.03.103","volume":"22","author":"Lieberman","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.110"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1200\/jco.2004.22.14_suppl.1505","volume":"22","author":"Uhm","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0022-3565(24)35162-6","volume":"291","author":"Pollack","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1200\/JCO.2001.19.13.3267","volume":"19","author":"Hidalgo","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"CIT0037","doi-asserted-by":"crossref","first-page":"S4238","DOI":"10.1158\/1078-0432.CCR-040017","volume":"10","author":"Perez-Soler","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1215\/S1522851705000451"},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1200\/JCO.2005.10.068","volume":"23","author":"Cloughesy","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5984"},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1200\/jco.2004.22.14_suppl.1502","volume":"23","author":"Raizer","year":"2004","journal-title":"Proc. Am. Soc. Clin. Oncol."},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1200\/jco.2004.22.14_suppl.1558","volume":"22","author":"Vogelbaum","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"CIT0043","first-page":"448","volume":"8","author":"Peereboom","year":"2006","journal-title":"Neuro. Oncol."},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0421"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji161"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051918"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-suppl_3-10"},{"key":"CIT0048","first-page":"7196","volume":"61","author":"Rusnak","year":"2001","journal-title":"Cancer Res."},{"key":"CIT0049","first-page":"783","volume":"10","author":"Kuhn","year":"2008","journal-title":"Neuro Oncol."},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1227\/01.NEU.0000145865.25689.55","volume":"56","author":"Eller","year":"2005","journal-title":"Neurosurgery"},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/annonc\/mdp032","volume":"20","author":"Neyns","year":"2009","journal-title":"Ann. Oncol."},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1101\/gad.891601"},{"key":"CIT0053","first-page":"164","volume":"56","author":"Hermanson","year":"1996","journal-title":"Cancer Res."},{"key":"CIT0054","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3171\/jns.1991.75.2.0284","volume":"75","author":"Pollack","year":"1991","journal-title":"J. Neurosurg."},{"key":"CIT0055","first-page":"3729","volume":"62","author":"Lokker","year":"2002","journal-title":"Cancer Res."},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2004.03.002"},{"key":"CIT0057","first-page":"5143","volume":"60","author":"Kilic","year":"2000","journal-title":"Cancer Res."},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.08.025"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441401"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022457"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441404"},{"key":"CIT0062","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-3565(24)38879-2","volume":"295","author":"Buchdunger","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0773"},{"key":"CIT0064","first-page":"2929","volume":"61","author":"Pietras","year":"2001","journal-title":"Cancer Res."},{"key":"CIT0065","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1200\/JCO.2008.16.9235","volume":"26","author":"Raymond","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"CIT0066","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1200\/jco.2006.24.18_suppl.1526","volume":"24","author":"Marosi","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"CIT0067","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/00005072-199911000-00007","volume":"58","author":"Schmidt","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"CIT0068","first-page":"2331","volume":"58","author":"Cheney","year":"1998","journal-title":"Cancer Res."},{"key":"CIT0069","first-page":"2742","volume":"63","author":"Choe","year":"2003","journal-title":"Cancer Res."},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1038\/ng0497-356"},{"key":"CIT0071","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000028729","volume":"29","author":"Pollack","year":"1998","journal-title":"Pediatr. Neurosurg."},{"key":"CIT0072","first-page":"327","volume":"9","author":"Peddanna","year":"1996","journal-title":"Int. J. Oncol."},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.41.25639"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201455"},{"key":"CIT0075","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/00006123-199807000-00081","volume":"43","author":"Bredel","year":"1998","journal-title":"Neurosurgery"},{"key":"CIT0076","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1200\/JCO.1999.17.11.3631","volume":"17","author":"Rowinsky","year":"1999","journal-title":"J. Clin. Oncol."},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202175"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.1.139-148.2000"},{"key":"CIT0079","doi-asserted-by":"crossref","first-page":"7514","DOI":"10.1038\/sj.onc.1203105","volume":"18","author":"Feldkamp","year":"1999","journal-title":"Oncogene"},{"key":"CIT0080","first-page":"131","volume":"61","author":"End","year":"2001","journal-title":"Cancer Res."},{"key":"CIT0081","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1182\/blood-2003-08-2764","volume":"103","author":"Alsina","year":"2004","journal-title":"Blood"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.037"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.112"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.2323"},{"key":"CIT0085","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1215\/15228517-2008-070","volume":"10","author":"Lustig","year":"2008","journal-title":"Neuro. Oncol."},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.4243"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf173"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21188"},{"key":"CIT0089","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1242\/jcs.96.1.107","volume":"96","author":"Fields","year":"1990","journal-title":"J. Cell Sci."},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1038\/364249a0"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5360.109"},{"key":"CIT0092","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1227\/00006123-199112000-00013","volume":"29","author":"Couldwell","year":"1991","journal-title":"Neurosurgery"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.84.6.1024"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2740"},{"key":"CIT0095","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1200\/JCO.1999.17.2.645","volume":"17","author":"Brandes","year":"1999","journal-title":"J. Clin. Oncol."},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEON.0000040837.68411.97"},{"key":"CIT0097","first-page":"617","volume":"23","author":"Hercbergs","year":"2003","journal-title":"Anticancer Res."},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-003-0713-x"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0071"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.3447"},{"key":"CIT0101","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1200\/jco.2005.23.16_suppl.1504","volume":"23","author":"Fine","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"CIT0102","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1126\/science.8085158","volume":"265","author":"Freed","year":"1994","journal-title":"Science"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90361-F"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1443"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.108621"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0284"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.07.193"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1038\/378785a0"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5392.1318"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.8.4240"},{"key":"CIT0111","doi-asserted-by":"crossref","first-page":"15406","DOI":"10.1073\/pnas.95.26.15406","volume":"95","author":"Li","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"CIT0112","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11060-004-1718-y","volume":"71","author":"Nakamura","year":"2005","journal-title":"J. Neurooncol."},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1042"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.4.1.105"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-005-1444-0"},{"key":"CIT0116","first-page":"1527","volume":"61","author":"Geoerger","year":"2001","journal-title":"Cancer Res."},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.23.622"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1044"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1385"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604995"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-08-0017"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-8871-3_19"},{"key":"CIT0123","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.hoc.2004.05.003","volume":"18","author":"Purow","year":"2004","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"CIT0124","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00018-007-6342-5","volume":"64","author":"Nakada","year":"2007","journal-title":"Cell Mol. Life Sci."},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-004-2752-5"},{"key":"CIT0126","first-page":"5879","volume":"60","author":"Maity","year":"2000","journal-title":"Cancer Res."},{"key":"CIT0127","first-page":"1459","volume":"7","author":"Ciardiello","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"CIT0128","first-page":"4300","volume":"62","author":"Huang","year":"2002","journal-title":"Cancer Res."},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1038\/35025215"},{"key":"CIT0130","first-page":"1464","volume":"59","author":"Wang","year":"1999","journal-title":"Cancer Res."},{"key":"CIT0131","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1200\/jco.2004.22.14_suppl.1512","volume":"22","author":"Conrad","year":"2004","journal-title":"J. Clin. Oncol. (Meeting Abstracts)"},{"key":"CIT0132","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1200\/jco.2004.22.14_suppl.1512","volume":"22","author":"Conrad","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"CIT0133","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.11.021"},{"key":"CIT0134","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2309"},{"key":"CIT0135","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1093\/ajhp\/61.suppl_5.S21","volume":"61","author":"Ignoffo","year":"2004","journal-title":"Am. J. Health Syst. Pharm."},{"key":"CIT0136","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032691"},{"key":"CIT0137","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021491"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.2440"},{"key":"CIT0139","doi-asserted-by":"crossref","first-page":"2010b","DOI":"10.1200\/jco.2008.26.15_suppl.2010b","volume":"26","author":"Cloughesy","year":"2008","journal-title":"J. Clin. Oncol. (Meeting Abstracts)"},{"key":"CIT0140","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.3055"},{"key":"CIT0141","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.172398299"},{"key":"CIT0142","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1200\/JCO.2000.18.4.708","volume":"18","author":"Fine","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"CIT0143","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.08.045"},{"key":"CIT0144","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199904000-00001"},{"key":"CIT0145","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.7510"},{"key":"CIT0146","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-2-152"},{"key":"CIT0147","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20776"},{"key":"CIT0148","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-004-0620-5"},{"key":"CIT0149","first-page":"872","volume":"9","author":"Badie","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"CIT0150","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/sj.gt.3302287","volume":"11","author":"Barnett","year":"2004","journal-title":"Gene Ther."},{"key":"CIT0151","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1200\/jco.2005.23.16_suppl.1526","volume":"23","author":"Phuphanich","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"CIT0152","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10265"},{"key":"CIT0153","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.15.1210"},{"key":"CIT0154","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.5080"},{"key":"CIT0155","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950170510"},{"key":"CIT0156","first-page":"2292","volume":"7","author":"Gilbert","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"CIT0157","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1023\/A:1019905127442","volume":"59","author":"Baker","year":"2002","journal-title":"J. Neurooncol."},{"key":"CIT0158","first-page":"721","volume":"2","author":"Plumb","year":"2003","journal-title":"Mol. Cancer Ther."},{"key":"CIT0159","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.12.088"},{"key":"CIT0160","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.0694"},{"key":"CIT0161","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1361"},{"key":"CIT0162","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/sj.onc.1208225","volume":"24","author":"Yin","year":"2004","journal-title":"Oncogene"},{"key":"CIT0163","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1200\/jco.2006.24.18_suppl.1567","volume":"24","author":"Phuphanich","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"CIT0164","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1215\/S1152851704001188","volume":"7","author":"Graner","year":"2005","journal-title":"Neuro. Oncol."},{"key":"CIT0165","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/mc.20141","volume":"45","author":"Premkumar","year":"2006","journal-title":"Mol. Carcinog."},{"key":"CIT0166","first-page":"323","volume":"4","author":"Hutchinson","year":"2007","journal-title":"Nature"},{"key":"CIT0167","doi-asserted-by":"publisher","DOI":"10.1126\/science.1142946"},{"key":"CIT0168","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2008.12.005"},{"key":"CIT0169","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/ncponc0200","volume":"2","author":"Giaccone","year":"2005","journal-title":"Nat. Clin. Prac. Oncol."},{"key":"CIT0170","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1056\/NEJM200507143530217","volume":"353","author":"Shih","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"CIT0171","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1158\/1535-7163.101.4.1","volume":"4","author":"Goudar","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"CIT0172","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0319"},{"key":"CIT0173","first-page":"4009","volume":"63","author":"Schueneman","year":"2003","journal-title":"Cancer Res."},{"key":"CIT0174","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1200\/JCO.2008.19.1650","volume":"27","author":"Neyns","year":"2009","journal-title":"J. Clin. Oncol. (Meeting Abstracts)"},{"key":"CIT0175","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0160"},{"key":"CIT0176","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.9356"},{"key":"CIT0177","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.4741"},{"key":"CIT0178","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0521"},{"key":"CIT0179","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4392"},{"key":"CIT0180","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1200\/JCO.2005.03.5303","volume":"24","author":"Nguyen","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"CIT0181","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000014"},{"key":"CIT0182","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2215"},{"key":"CIT0183","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000223844.77636.29"},{"key":"CIT0184","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1200\/jco.2009.27.15_suppl.2004","volume":"27","author":"Chang","year":"2009","journal-title":"J. Clin. Oncol. (Meeting Abstracts)"},{"key":"CIT0185","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1200\/jco.2009.27.15_suppl.2006","volume":"27","author":"Wen","year":"2009","journal-title":"J. Clin. Oncol. (Meeting Abstracts)"},{"key":"CIT0186","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1200\/jco.2009.27.15_suppl.2005","volume":"27","author":"Prados","year":"2009","journal-title":"J. Clin. Oncol. (Meeting Abstracts)"},{"key":"CIT0187","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1200\/JCO.2000.18.4.904","volume":"18","author":"Baselga","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"CIT0188","first-page":"1936","volume":"6","author":"Bruns","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"CIT0189","first-page":"2053","volume":"6","author":"Ciardiello","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"CIT0190","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/sj.leu.2402041","volume":"15","author":"Topaly","year":"2001","journal-title":"Leukemia"},{"key":"CIT0191","first-page":"5476","volume":"62","author":"Pietras","year":"2002","journal-title":"Cancer Res."},{"key":"CIT0192","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2004.06.002"},{"key":"CIT0193","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1368-8375(01)00029-X","volume":"38","author":"O-charoenrat","year":"2002","journal-title":"Oral Oncol."},{"key":"CIT0194","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.4.1.121"},{"key":"CIT0195","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/j.1939-4640.2001.tb02199.x","volume":"22","author":"Ravindranath","year":"2001","journal-title":"J. Androl."},{"key":"CIT0196","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ijrobp.2005.05.050","volume":"64","author":"Frederick","year":"2006","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"CIT0197","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4905"},{"key":"CIT0198","first-page":"1523","volume":"151","author":"Petit","year":"1997","journal-title":"Am. J. Pathol."},{"key":"CIT0199","first-page":"257","volume":"5","author":"Perrotte","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"CIT0200","first-page":"3739","volume":"6","author":"Ciardiello","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"CIT0201","first-page":"4874","volume":"6","author":"Inoue","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"CIT0202","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/ncponc1161","volume":"5","author":"Tortora","year":"2008","journal-title":"Nat. Clin. Prac. Oncol."},{"key":"CIT0203","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2270"},{"key":"CIT0204","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1200\/jco.2009.27.15_suppl.2045","volume":"27","author":"Sathornsumetee","year":"2009","journal-title":"J. Clin. Oncol. (Meeting Abstracts)"},{"key":"CIT0205","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1023\/B:NEON.0000021803.01170.03","volume":"67","author":"Baumann","year":"2004","journal-title":"J. Neurooncol."},{"key":"CIT0206","first-page":"8890","volume":"63","author":"Abdollahi","year":"2003","journal-title":"Cancer Res."},{"key":"CIT0207","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1200\/jco.2007.25.18_suppl.2038","volume":"25","author":"Friday","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"CIT0208","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11307"},{"key":"CIT0209","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1200\/JCO.2005.04.7522","volume":"24","author":"Butowski","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"CIT0210","first-page":"4307","volume":"62","author":"Chakravarti","year":"2002","journal-title":"Cancer Res."},{"key":"CIT0211","first-page":"1935","volume":"59","author":"Huang","year":"1999","journal-title":"Cancer Res."},{"key":"CIT0212","first-page":"701","volume":"6","author":"Milas","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"CIT0213","doi-asserted-by":"crossref","first-page":"10842","DOI":"10.1073\/pnas.95.18.10842","volume":"95","author":"O\u2019Rourke","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"CIT0214","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1200\/JCO.2008.18.0612","volume":"26","author":"Brown","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"CIT0215","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1200\/JCO.2008.18.9639","volume":"27","author":"Prados","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"CIT0216","doi-asserted-by":"crossref","unstructured":"Chakravarti A, Berkey B, Robins Het al.An update of Phase II results from RTOG 0211: a Phase I\/II study of gefitinib with radiotherapy in newly diagnosed glioblastoma.Program and Abstracts of the American Association for Cancer Research 97th Annual Meeting. Washington, DC, USA, 1\u20135 April 2006.","DOI":"10.1200\/jco.2006.24.18_suppl.1527"},{"key":"CIT0217","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ctrv.2006.03.006","volume":"32","author":"Carsten","year":"2006","journal-title":"Cancer Treat. Rev."},{"key":"CIT0218","first-page":"553","volume":"6","author":"Winkler","year":"2004","journal-title":"Cancer Cell"},{"key":"CIT0219","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.semradonc.2009.02.004","volume":"19","author":"Barcellos-Hoff","year":"2009","journal-title":"Semin. Radiat. Oncol."},{"key":"CIT0220","first-page":"243","volume":"487","author":"Aharinejad","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"CIT0221","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1517\/17425240902988470","volume":"6","author":"Stukel","year":"2009","journal-title":"Expert Opin. Drug Deliv.,"},{"key":"CIT0222","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1586\/14737175.7.4.363","volume":"7","author":"Jain","year":"2007","journal-title":"Expert Rev. Neurother."},{"key":"CIT0223","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1517\/17425240902939143","volume":"6","author":"Barbu","year":"2009","journal-title":"Expert Opin. Drug Deliv."},{"key":"CIT0224","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3747\/co.v15i4.362","volume":"15","author":"DeAngelis","year":"2008","journal-title":"Curr. Oncol."},{"key":"CIT0225","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S1359-6349(07)70073-3","volume":"15","author":"Mulder","year":"2007","journal-title":"Eur. J. Cancer Suppl."},{"key":"CIT0226","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/clpt.2008.245","volume":"85","author":"Sleijfer","year":"2009","journal-title":"Clin. Pharmacol. Ther."},{"key":"CIT0227","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp048143"},{"key":"CIT0228","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r135"},{"key":"CIT0229","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.61"},{"key":"CIT0230","doi-asserted-by":"publisher","DOI":"10.1038\/nature05697"},{"key":"CIT0231","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.006"},{"key":"CIT0232","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043331"},{"key":"CIT0233","doi-asserted-by":"crossref","first-page":"12503","DOI":"10.1200\/jco.2007.25.18_suppl.12503","volume":"25","author":"Lassen","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"CIT0234","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.01.018"}],"container-title":["Expert Review of Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1586\/ern.09.116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T15:05:32Z","timestamp":1739459132000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1586\/ern.09.116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":234,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,1,9]]},"published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1586\/ern.09.116"],"URL":"https:\/\/doi.org\/10.1586\/ern.09.116","relation":{},"ISSN":["1473-7175","1744-8360"],"issn-type":[{"value":"1473-7175","type":"print"},{"value":"1744-8360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}