{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:39:58Z","timestamp":1768095598674,"version":"3.49.0"},"reference-count":120,"publisher":"Informa UK Limited","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Review of Neurotherapeutics"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1586\/ern.09.25","type":"journal-article","created":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T13:43:10Z","timestamp":1241012590000},"page":"695-709","source":"Crossref","is-referenced-by-count":24,"title":["Cholesterol-modifying strategies for Alzheimer\u2019s disease"],"prefix":"10.1586","volume":"9","author":[{"given":"Alina","family":"Solomon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miia","family":"Kivipelto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2014,1,9]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91705-Q"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(90)90024-T"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.11.012"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.11.081"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2006.07.007"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.066"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982595"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00685.x"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.8.1447"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000070182.02537.84"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.1.103"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000256368.57375.b7"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1159\/000093478"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000120374.59826.1b"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2005.01.005"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.02.019"},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1007\/s00018-003-3018-7","volume":"60","author":"Pfrieger","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.4.5.823"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01725.x"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04689.x"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00966.2005"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1044"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2000.0304"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200203250-00019"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20289"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20469"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9652"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1999.tb00724.x"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(99)00103-7"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm027"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00681.x"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04715.x"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00018-0"},{"key":"CIT0035","author":"Hirsch-Reinshagen","year":"2008","journal-title":"Mol. Cell. Biochem."},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.06.004"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.10.005"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1313"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1080\/09687860500496417"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M701823200"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1038\/nn0403-345"},{"key":"CIT0042","first-page":"117","volume":"24","author":"Garcia-Ruiz","year":"2009","journal-title":"Histol. Histopathol."},{"key":"CIT0043","author":"Koschack","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.08.014"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300320-JLR200"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02277-7"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402324200"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2008.00174.x"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.08.002"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2006.28.9.1003573"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.9.10.1475"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200104170-00003"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0422"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-002-0026-2"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.075028"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:8:3:319"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081620098"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2004.03.012"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.094136"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2008.08.007"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01654-4"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.05.001"},{"key":"CIT0063","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3233\/JAD-2001-3207","volume":"3","author":"Buxbaum","year":"2001","journal-title":"J. Alzheimers Dis."},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00155-0"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1042\/BST0350577"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702640200"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00054.x"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2544-04.2005"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21053"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200721060-00002"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03155-X"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.2.223"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1159\/000073981"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.5.705"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000142963.90204.58"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.2.217"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.7.1047"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200607001-00027"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-5-20"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000288181.00826.63"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03308.x"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.150433"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.2174\/156720508785132316"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.3.378"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000182897.18229.ec"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-005-0073-z"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000277657.95487.1c"},{"key":"CIT0088","author":"Solomon","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1159\/000111583"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000279333.77404.d7"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1159\/000115847"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000319647.15752.7b"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00353-3"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09327-3"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11600-X"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.07.041"},{"key":"CIT0097","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3233\/JAD-2008-13209","volume":"13","author":"Carlsson","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00688.x"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb03839.x"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.02.030"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10292"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.5.753"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00690.x"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.75.Suppl_2.S87"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000159743.08996.99"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2008.02.001"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.160291"},{"key":"CIT0108","unstructured":"Sparks DL, Kivipelto M, Doody Ret al.The Atorvastatin\/Donepezil in Alzheimer\u2019s Disease (LEADe) study: effect of atorvastatin on Alzheimer\u2019s disease progression by ApoE4 genotype. Presented at:Alzheimer\u2019s Association International Conference on Alzheimer\u2019s Disease. Chicago, IL, USA, 26\u201331 July 2008 (Abstract)."},{"key":"CIT0109","doi-asserted-by":"crossref","unstructured":"Sano M. Multi-center, randomized, double-blind, placebo-controlled trial of Simvastatin to slow the progression of Alzheimer\u2019s disease. Presented at:Alzheimer\u2019s Association International Conference on Alzheimer\u2019s DiseaseChicago, IL, USA, 26\u201331 July 2008 (Abstract T200).","DOI":"10.1016\/j.jalz.2008.05.562"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.063388"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.104034"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e318181276a"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318180f55b"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200724010-00004"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1159\/000107395"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1159\/000094973"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.525"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00296.x"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70537-3"}],"container-title":["Expert Review of Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1586\/ern.09.25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T19:10:41Z","timestamp":1558293041000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1586\/ern.09.25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":120,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,1,9]]},"published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1586\/ern.09.25"],"URL":"https:\/\/doi.org\/10.1586\/ern.09.25","relation":{},"ISSN":["1473-7175","1744-8360"],"issn-type":[{"value":"1473-7175","type":"print"},{"value":"1744-8360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}