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Solid-State Circuits <b>55<\/b> (2020) 2756 (DOI: 10.1109\/JSSC.2020.3007177).","DOI":"10.1109\/JSSC.2020.3007177"},{"key":"4","doi-asserted-by":"crossref","unstructured":"[4] K. Park and W.-S. Oh: \u201cA PWM based readout circuit for optical sensors with adaptive frequency control,\u201d IEICE Electron. Express <b>15<\/b> (2018) 20180613 (DOI: 10.1587\/elex.15.20180613).","DOI":"10.1587\/elex.15.20180613"},{"key":"5","doi-asserted-by":"crossref","unstructured":"[5] G. Atzeni, <i>et al<\/i>.: \u201cA 0.45\/0.2-NEF\/PEF 12-nV\/\u221aHz highly configurable discrete-time low-noise amplifier,\u201d IEEE Solid-State Circuits Lett. <b>3<\/b> (2020) 486 (DOI: 10.1109\/LSSC.2020.3029016).","DOI":"10.1109\/LSSC.2020.3029016"},{"key":"6","doi-asserted-by":"crossref","unstructured":"[6] P. Harpe, <i>et al<\/i>.: \u201cA 0.20\u2006mm<sup>2<\/sup> 3\u2006nW signal acquisition IC for miniature sensor nodes in 65\u2006nm CMOS,\u201d IEEE J. Solid-State Circuits <b>51<\/b> (2016) 240 (DOI: 10.1109\/JSSC.2015.2487270).","DOI":"10.1109\/JSSC.2015.2487270"},{"key":"7","doi-asserted-by":"crossref","unstructured":"[7] L. Shen, <i>et al<\/i>.: \u201cA 1-V 0.25-<i>\u03bc<\/i>W inverter stacking amplifier with 1.07 noise efficiency factor,\u201d IEEE J. Solid-State Circuits <b>53<\/b> (2018) 896 (DOI: 10.1109\/JSSC.2017.2786724).","DOI":"10.1109\/JSSC.2017.2786724"},{"key":"8","doi-asserted-by":"crossref","unstructured":"[8] B. Johnson and A. Molnar: \u201cAn orthogonal current-reuse amplifier for multi-channel sensing,\u201d IEEE J. Solid-State Circuits <b>48<\/b> (2013) 1487 (DOI: 10.1109\/JSSC.2013.2257478).","DOI":"10.1109\/JSSC.2013.2257478"},{"key":"9","doi-asserted-by":"crossref","unstructured":"[9] Z. Liang, <i>et al<\/i>.: \u201cA high input impedance chopper amplifier using negative impedance convertor for implantable EEG recording,\u201d IEICE Electron. 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Xu, <i>et al<\/i>.: \u201cA 0.69\/0.58-PEF 1.6\u2006nW\/24\u2006nW capacitively coupled chopper instrumentation amplifier with an input-boosted first stage in 22\u2006nm\/180\u2006nm CMOS,\u201d 2024 IEEE International Solid-State Circuits Conference (ISSCC) (2024) 72 (DOI: 10.1109\/ISSCC49657.2024.10454416).","DOI":"10.1109\/ISSCC49657.2024.10454416"},{"key":"13","doi-asserted-by":"crossref","unstructured":"[13] S. Abdelfattah, <i>et al<\/i>.: \u201cChopper instrumentation amplifier design with fully symmetric loops for input impedance boosting,\u201d IEEE Trans. Circuits Syst. I, Reg. Papers <b>71<\/b> (2024) 4434 (DOI: 10.1109\/TCSI.2024.3440278).","DOI":"10.1109\/TCSI.2024.3440278"},{"key":"14","doi-asserted-by":"crossref","unstructured":"[14] M. Maruyama, <i>et al<\/i>.: \u201cAn analog front-end for a multifunction sensor employing a weak-inversion biasing technique with 26\u2006nVrms, 25\u2006aCrms, and 19\u2006fArms input-referred noise,\u201d IEEE J. Solid-State Circuits <b>51<\/b> (2016) 2252 (DOI: 10.1109\/JSSC.2016.2581812).","DOI":"10.1109\/JSSC.2016.2581812"},{"key":"15","doi-asserted-by":"crossref","unstructured":"[15] S. Song, <i>et al<\/i>.: \u201cA low-voltage chopper-stabilized amplifier for fetal ECG monitoring with a 1.41 power efficiency factor,\u201d IEEE Trans. Biomed. Circuits Syst. <b>9<\/b> (2015) 237 (DOI: 10.1109\/TBCAS.2015.2417124).","DOI":"10.1109\/TBCAS.2015.2417124"},{"key":"16","doi-asserted-by":"crossref","unstructured":"[16] M.S.J. Steyaert and W.M.C. Sansen: \u201cA micropower low-noise monolithic instrumentation amplifier for medical purposes,\u201d IEEE J. Solid-State Circuits <b>22<\/b> (1987) 1163 (DOI: 10.1109\/JSSC.1987.1052869).","DOI":"10.1109\/JSSC.1987.1052869"},{"key":"17","doi-asserted-by":"crossref","unstructured":"[17] G. Atzeni, <i>et al<\/i>.: \u201cAn impedance-boosted transformer-first discrete-time analog front-end achieving 0.34 NEF and 389-M\u03a9 input impedance,\u201d IEEE J. Solid-State Circuits <b>59<\/b> (2024) 1026 (DOI: 10.1109\/JSSC.2024.3354243).","DOI":"10.1109\/JSSC.2024.3354243"},{"key":"18","doi-asserted-by":"crossref","unstructured":"[18] F.M. Yaul and A.P. Chandrakasan: \u201cA noise-efficient 36\u2006nV\/\u221aHz chopper amplifier using an inverter-based 0.2-V supply input stage,\u201d IEEE J. Solid-State Circuits <b>52<\/b> (2017) 3032 (DOI: 10.1109\/JSSC.2017.2746778).","DOI":"10.1109\/JSSC.2017.2746778"},{"key":"19","doi-asserted-by":"crossref","unstructured":"[19] X.T. Pham, <i>et al<\/i>.: \u201cA 0.52\u2006<i>\u03bc<\/i>W, 38\u2006nV\/\u221aHz chopper amplifier with a low-noise DC servo loop, an embedded ripple reduction loop, and a squeezed inverter stage,\u201d IEEE Trans. Circuits Syst. II, Exp. Briefs <b>68<\/b> (2021) 1793 (DOI: 10.1109\/TCSII.2020.3045491).","DOI":"10.1109\/TCSII.2020.3045491"},{"key":"20","doi-asserted-by":"crossref","unstructured":"[20] Y.-P. 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Kalani, <i>et al<\/i>.: \u201cA 0.2\u2006V 492\u2006nW VCO-based OTA with 60\u2006kHz UGB and 207\u2006<i>\u03bc<\/i>V<sub>RMS<\/sub> noise,\u201d 2017 IEEE International Symposium on Circuits and Systems (ISCAS) (2017) 1 (DOI: 10.1109\/ISCAS.2017.8050503).","DOI":"10.1109\/ISCAS.2017.8050503"},{"key":"24","doi-asserted-by":"crossref","unstructured":"[24] W. Deng, <i>et al<\/i>.: \u201cA fully synthesizable all-digital PLL with interpolative phase coupled oscillator, current-output DAC, and fine-resolution digital varactor using gated edge injection technique,\u201d IEEE J. Solid-State Circuits <b>50<\/b> (2015) 68 (DOI: 10.1109\/JSSC.2014.2348311).","DOI":"10.1109\/JSSC.2014.2348311"},{"key":"25","doi-asserted-by":"crossref","unstructured":"[25] S. Bang, <i>et al<\/i>.: \u201cA fully synthesizable distributed and scalable all-digital LDO in 10\u2006nm CMOS,\u201d 2020 IEEE International Solid-State Circuits Conference - (ISSCC) (2020) 380 (DOI: 10.1109\/ISSCC19947.2020.9063040).","DOI":"10.1109\/ISSCC19947.2020.9063040"},{"key":"26","doi-asserted-by":"crossref","unstructured":"[26] Q. Fan, <i>et al<\/i>.: \u201cA 1.8\u2006<i>\u03bc<\/i>W 60\u2006nV\/\u221aHz capacitively-coupled chopper instrumentation amplifier in 65\u2006nm CMOS for wireless sensor nodes,\u201d IEEE J. Solid-State Circuits <b>46<\/b> (2011) 1534 (DOI: 10.1109\/JSSC.2011.2143610).","DOI":"10.1109\/JSSC.2011.2143610"},{"key":"27","doi-asserted-by":"crossref","unstructured":"[27] D.-H. Le and T.-H. Pham: \u201cDesign of a 1.8-<i>\u03bc<\/i>Vrms IRN 180-dB CMRR configurable low-noise 6-channel analog front-end for neural recording systems on 180\u2006nm CMOS process,\u201d IEICE Electron. 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Wang, <i>et al<\/i>.: \u201cA 0.5\u2006V 10-bit SAR ADC with offset calibrated time-domain comparator,\u201d AEU - International Journal of Electronics and Communications <b>178<\/b> (2024) 155261 (DOI: 10.1016\/j.aeue.2024.155261).","DOI":"10.1016\/j.aeue.2024.155261"},{"key":"31","doi-asserted-by":"crossref","unstructured":"[31] J.L. Valtierra, <i>et al<\/i>.: \u201cA sub-uW reconfigurable front-end for invasive neural recording that exploits the spectral characteristics of the wideband neural signal,\u201d IEEE Trans. Circuits Syst. I, Reg. Papers <b>67<\/b> (2020) 1426 (DOI: 10.1109\/TCSI.2020.2968087).","DOI":"10.1109\/TCSI.2020.2968087"},{"key":"32","doi-asserted-by":"crossref","unstructured":"[32] C. Cabrera, <i>et al<\/i>.: \u201cLow-voltage low-noise high-CMRR biopotential integrated preamplifier,\u201d IEEE Trans. Circuits Syst. I, Reg. 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