{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:29:24Z","timestamp":1770748164783,"version":"3.49.0"},"reference-count":42,"publisher":"Society of Physical Therapy Science","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Phys Ther Sci"],"published-print":{"date-parts":[[2015]]},"DOI":"10.1589\/jpts.27.2225","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T22:02:41Z","timestamp":1437516161000},"page":"2225-2231","source":"Crossref","is-referenced-by-count":29,"title":["Does aerobic exercise affect the hypothalamic-pituitary-adrenal hormonal response in patients with fibromyalgia syndrome?"],"prefix":"10.1589","volume":"27","author":[{"given":"Aysun","family":"Genc","sequence":"first","affiliation":[{"name":"Physiotherapy Programme, Ankara University Vocational School of Haymana: Turan Gunes Bulvari, Park Oran Sitesi, B5\/28 06450, Oran, Cankaya, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birkan Sonel","family":"Tur","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yesim Kurtais","family":"Aytur","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Oztuna","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Ankara University Faculty of Medicine, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat Faik","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Ankara University Faculty of Medicine, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"533","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Bennett RM, Jones J, Turk DC, et al.: An internet survey of 2,596 people with fibromyalgia. BMC Musculoskelet Disord, 2007, 8: 27.","DOI":"10.1186\/1471-2474-8-27"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Crofford LJ, Pillemer SR, Kalogeras KT, et al.: Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. Arthritis Rheum, 1994, 37: 1583\u20131592.","DOI":"10.1002\/art.1780371105"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Adler GK, Kinsley BT, Hurwitz S, et al.: Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome. Am J Med, 1999, 106: 534\u2013543.","DOI":"10.1016\/S0002-9343(99)00074-1"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Wingenfeld K, Nutzinger D, Kauth J, et al.: Salivary cortisol release and hypothalamic pituitary adrenal axis feedback sensitivity in fibromyalgia is associated with depression but not with pain. J Pain, 2010, 11: 1195\u20131202.","DOI":"10.1016\/j.jpain.2010.02.011"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Riva R, Mork PJ, Westgaard RH, et al.: Fibromyalgia syndrome is associated with hypocortisolism. Int J Behav Med, 2010, 17: 223\u2013233.","DOI":"10.1007\/s12529-010-9097-6"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Cuatrecasas G, Gonzalez MJ, Alegre C, et al.: High prevalence of growth hormone deficiency in severe fibromyalgia syndromes. J Clin Endocrinol Metab, 2010, 95: 4331\u20134337.","DOI":"10.1210\/jc.2010-0061"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Crofford LJ, Demitrack MA: Evidence that abnormalities of central neurohormonal systems are key to understanding fibromyalgia and chronic fatigue syndrome. Rheum Dis Clin North Am, 1996, 22: 267\u2013284.","DOI":"10.1016\/S0889-857X(05)70272-6"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Thomas EN, Blotman F: Aerobic exercise in fibromyalgia: a practical review. Rheumatol Int, 2010, 30: 1143\u20131150.","DOI":"10.1007\/s00296-010-1369-6"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Vural M, Berkol TD, Erdogdu Z, et al.: Evaluation of the effectiveness of an aerobic exercise program and the personality characteristics of patients with fibromyalgia syndrome: a pilot study. J Phys Ther Sci, 2014, 26: 1561\u20131565.","DOI":"10.1589\/jpts.26.1561"},{"key":"10","unstructured":"10) Kjaer M, Dela FM: Endocrine responses to exercise. In: Goetz-Hoffman L, ed. Exercise and immune function. Florida: CRC Press, 1996, pp 1\u201319."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Hill EE, Zack E, Battaglini C, et al.: Exercise and circulating cortisol levels: the intensity threshold effect. J Endocrinol Invest, 2008, 31: 587\u2013591.","DOI":"10.1007\/BF03345606"},{"key":"12","unstructured":"12) Valim V, Oliveira L, Suda A, et al.: Aerobic fitness effects in fibromyalgia. J Rheumatol, 2003, 30: 1060\u20131069."},{"key":"13","unstructured":"13) Ortega E, Garc\u00eda JJ, Bote ME, et al.: Exercise in fibromyalgia and related inflammatory disorders: known effects and unknown chances. Exerc Immunol Rev, 2009, 15: 42\u201365."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) G\u00fcrsel Y, Ergin S, Ulus Y, et al.: Hormonal responses to exercise stress test in patients with fibromyalgia syndrome. Clin Rheumatol, 2001, 20: 401\u2013405.","DOI":"10.1007\/s100670170003"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Wolfe F, Smythe HA, Yunus MB, et al.: The American College of Rheumatology 1990 criteria for the classification of Fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum, 1990, 33: 160\u2013172.","DOI":"10.1007\/978-3-642-86812-2_2"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Aloisi AM, Buonocore M, Merlo L, et al.: Chronic pain therapy and hypothalamic-pituitary-adrenal axis impairment. Psychoneuroendocrinology, 2011, 36: 1032\u20131039.","DOI":"10.1016\/j.psyneuen.2010.12.017"},{"key":"17","unstructured":"17) Burckhardt CS, Clark SR, Bennett RM: The fibromyalgia impact questionnaire: development and validation. J Rheumatol, 1991, 18: 728\u2013733."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Sarmer S, Ergin S, Yavuzer G: The validity and reliability of the Turkish version of the Fibromyalgia Impact Questionnaire. Rheumatol Int, 2000, 20: 9\u201312.","DOI":"10.1007\/s002960000077"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19) Ware JE Jr: SF-36 health survey update. Spine, 2000, 25: 3130\u20133139.","DOI":"10.1097\/00007632-200012150-00008"},{"key":"20","unstructured":"21) Kurtais Y, Tur BS, Elhan AH, et al.: Hypothalamic-pituitary-adrenal hormonal responses to exercise stress test in patients with rheumatoid arthritis compared to healthy controls. J Rheumatol, 2006, 33: 1530\u20131537."},{"key":"21","doi-asserted-by":"crossref","unstructured":"22) Beaver WL, Wasserman K, Whipp BJ: A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 1985, 1986, 60: 2020\u20132027.","DOI":"10.1152\/jappl.1986.60.6.2020"},{"key":"22","doi-asserted-by":"crossref","unstructured":"23) Arnold B, H\u00e4user W, Arnold M, et al.Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften: [Multicomponent therapy of fibromyalgia syndrome. Systematic review, meta-analysis and guideline]. Schmerz, 2012, 26: 287\u2013290.","DOI":"10.1007\/s00482-012-1173-1"},{"key":"23","doi-asserted-by":"crossref","unstructured":"24) Mannerkorpi K, Nordeman L, Cider A, et al.: Does moderate-to-high intensity Nordic walking improve functional capacity and pain in fibromyalgia? A prospective randomized controlled trial. Arthritis Res Ther, 2010, 12: R189.","DOI":"10.1186\/ar3159"},{"key":"24","doi-asserted-by":"crossref","unstructured":"25) Bircan C, Karasel SA, Akg\u00fcn B, et al.: Effects of muscle strengthening versus aerobic exercise program in fibromyalgia. Rheumatol Int, 2008, 28: 527\u2013532.","DOI":"10.1007\/s00296-007-0484-5"},{"key":"25","unstructured":"26) Mengshoel AM, Komnaes HB, F\u00f8rre O: The effects of 20 weeks of physical fitness training in female patients with fibromyalgia. Clin Exp Rheumatol, 1992, 10: 345\u2013349."},{"key":"26","doi-asserted-by":"crossref","unstructured":"27) Ross RL, Jones KD, Bennett RM, et al.: Preliminary evidence of increased pain and elevated cytokines in fibromyalgia patients with defective growth hormone response to exercise. Open Immunol J, 2010, 3: 9\u201318.","DOI":"10.2174\/1874226201003010009"},{"key":"27","doi-asserted-by":"crossref","unstructured":"28) Mehta A, Hindmarsh PC: The use of somatropin (recombinant growth hormone) in children of short stature. Paediatr Drugs, 2002, 4: 37\u201347.","DOI":"10.2165\/00128072-200204010-00005"},{"key":"28","doi-asserted-by":"crossref","unstructured":"29) Moldofsky H, Scarisbrick P, England R, et al.: Musculosketal symptoms and non-REM sleep disturbance in patients with \u201cfibrositis syndrome\u201d and healthy subjects. Psychosom Med, 1975, 37: 341\u2013351.","DOI":"10.1097\/00006842-197507000-00008"},{"key":"29","doi-asserted-by":"crossref","unstructured":"30) Jones KD, Deodhar P, Lorentzen A, et al.: Growth hormone perturbations in fibromyalgia: a review. Semin Arthritis Rheum, 2007, 36: 357\u2013379.","DOI":"10.1016\/j.semarthrit.2006.09.006"},{"key":"30","unstructured":"31) Jacobsen S, Main K, Danneskiold-Sams\u00f8e B, et al.: A controlled study on serum insulin-like growth factor-I and urinary excretion of growth hormone in fibromyalgia. J Rheumatol, 1995, 22: 1138\u20131140."},{"key":"31","unstructured":"32) Buchwald D, Umali J, Stene M: Insulin-like growth factor-I (somatomedin C) levels in chronic fatigue syndrome and fibromyalgia. J Rheumatol, 1996, 23: 739\u2013742."},{"key":"32","doi-asserted-by":"crossref","unstructured":"33) Berg U, Bang P: Exercise and circulating insulin-like growth factor I. Horm Res, 2004, 62: 50\u201358.","DOI":"10.1159\/000080759"},{"key":"33","unstructured":"34) Jones KD, Deodhar AA, Burckhardt CS, et al.: A combination of 6 months of treatment with pyridostigmine and triweekly exercise fails to improve insulin-like growth factor-I levels in fibromyalgia, despite improvement in the acute growth hormone response to exercise. J Rheumatol, 2007, 34: 1103\u20131111."},{"key":"34","doi-asserted-by":"crossref","unstructured":"35) Kirnap M, Colak R, Eser C, et al.: A comparison between low-dose (1 microg), standard-dose (250 microg) ACTH stimulation tests and insulin tolerance test in the evaluation of hypothalamo-pituitary-adrenal axis in primary fibromyalgia syndrome. Clin Endocrinol (Oxf), 2001, 55: 455\u2013459.","DOI":"10.1046\/j.1365-2265.2001.01373.x"},{"key":"35","doi-asserted-by":"crossref","unstructured":"36) Riedel W, Layka H, Neeck G: Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones. Z Rheumatol, 1998, 57: 81\u201387.","DOI":"10.1007\/s003930050242"},{"key":"36","doi-asserted-by":"crossref","unstructured":"37) Riedel W, Schlapp U, Leck S, et al.: Blunted ACTH and cortisol responses to systemic injection of corticotropin-releasing hormone (CRH) in fibromyalgia: role of somatostatin and CRH-binding protein. Ann N Y Acad Sci, 2002, 966: 483\u2013490.","DOI":"10.1111\/j.1749-6632.2002.tb04251.x"},{"key":"37","doi-asserted-by":"crossref","unstructured":"38) Wingenfeld K, Heim C, Schmidt I, et al.: HPA axis reactivity and lymphocyte glucocorticoid sensitivity in fibromyalgia syndrome and chronic pelvic pain. Psychosom Med, 2008, 70: 65\u201372.","DOI":"10.1097\/PSY.0b013e31815ff3ce"},{"key":"38","doi-asserted-by":"crossref","unstructured":"39) Catley D, Kaell AT, Kirschbaum C, et al.: A naturalistic evaluation of cortisol secretion in persons with fibromyalgia and rheumatoid arthritis. Arthritis Care Res, 2000, 13: 51\u201361.","DOI":"10.1002\/1529-0131(200002)13:1<51::AID-ART8>3.0.CO;2-Q"},{"key":"39","doi-asserted-by":"crossref","unstructured":"40) Gur A, Cevik R, Sarac AJ, et al.: Hypothalamic-pituitary-gonadal axis and cortisol in young women with primary fibromyalgia: the potential roles of depression, fatigue, and sleep disturbance in the occurrence of hypocortisolism. Ann Rheum Dis, 2004, 63: 1504\u20131506.","DOI":"10.1136\/ard.2003.014969"},{"key":"40","doi-asserted-by":"crossref","unstructured":"41) Maes M, Lin A, Bonaccorso S, et al.: Increased 24-hour urinary cortisol excretion in patients with post-traumatic stress disorder and patients with major depression, but not in patients with fibromyalgia. Acta Psychiatr Scand, 1998, 98: 328\u2013335.","DOI":"10.1111\/j.1600-0447.1998.tb10092.x"},{"key":"41","doi-asserted-by":"crossref","unstructured":"42) McLean SA, Williams DA, Harris RE, et al.: Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia. Arthritis Rheum, 2005, 52: 3660\u20133669.","DOI":"10.1002\/art.21372"},{"key":"42","doi-asserted-by":"crossref","unstructured":"43) Pollock M, Gaesser GA, Butcher JD, et al.: The recommend quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults. Med Sci Sports Exerc, 1998, 30: 975\u2013991.","DOI":"10.1097\/00005768-199806000-00032"}],"container-title":["Journal of Physical Therapy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jpts\/27\/7\/27_jpts-2015-152\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T18:25:08Z","timestamp":1652898308000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jpts\/27\/7\/27_jpts-2015-152\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1589\/jpts.27.2225","relation":{},"ISSN":["0915-5287","2187-5626"],"issn-type":[{"value":"0915-5287","type":"print"},{"value":"2187-5626","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}