{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:00:43Z","timestamp":1778536843902,"version":"3.51.4"},"reference-count":55,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Acad. Bras. Ci\u00eanc."],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Biflorin is an o-naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plant Capraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against grampositive and alcohol-acid-resistant bacteria. It has been efficient in inhibiting the proliferation tumor cell lines CEM, HL-60, B16, HCT-8 and MCF-7. Recently, SK-Br3 cell line was treated with biflorin showing important cytotoxic effects. In this article, information related to the first structural characterization studies are presented, as well as the latest reports concerning the biological activity of this molecule.<\/jats:p>","DOI":"10.1590\/0001-3765201420140085","type":"journal-article","created":{"date-parts":[[2014,10,11]],"date-time":"2014-10-11T14:51:31Z","timestamp":1413039091000},"page":"1907-1914","source":"Crossref","is-referenced-by-count":11,"title":["Biflorin: an o-naphthoquinone of clinical significance"],"prefix":"10.1590","volume":"86","author":[{"given":"GABRIELLE G.N.S.","family":"WISINTAINER","sequence":"first","affiliation":[{"name":"Universidade de Caxias do Sul, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EVELYNE R.B.","family":"SIM\u00d5ES","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TELMA L.G.","family":"LEMOS","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SIDNEI","family":"MOURA","sequence":"additional","affiliation":[{"name":"Universidade de Caxias do Sul, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUCIANA G.S.","family":"SOUZA","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALUISIO M.","family":"FONSECA","sequence":"additional","affiliation":[{"name":"Universidade da Integra\u00e7\u00e3o Internacional da Lusofonia Afro-Brasileira, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MANOEL ODORICO","family":"MORAES","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CLAUDIA","family":"PESSOA","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIANA","family":"ROESCH-ELY","sequence":"additional","affiliation":[{"name":"Universidade de Caxias do Sul, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JO\u00c3O A.P.","family":"HENRIQUES","sequence":"additional","affiliation":[{"name":"Universidade de Caxias do Sul, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/S0367-326X(03)00162-X","article-title":"Analgesic properties of Capraria biflora leaves aqueous extract","volume":"74","author":"Acosta SL","year":"2003","journal-title":"Fitoterapia"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0378-8741(90)90061-W","article-title":"Antiinflammatory action of lapachol","volume":"29","author":"Almeida ER","year":"1990","journal-title":"J Ethnopharmacol"},{"key":"ref3","first-page":"259","article-title":"Padroniza\u00e7\u00e3o Bot\u00e2nica de <em>Capraria biflora<\/em> L. 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