{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:53:18Z","timestamp":1773859998412,"version":"3.50.1"},"reference-count":45,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Acad. Bras. Ci\u00eanc."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>ABSTRACTUterine leiomyomas are benign soft-tissues tumors that arise from uterine smooth muscle tissue. Etiopathogenesis of leiomyomas is not well understood. We aimed to examine whether antioxidant enzyme activities and lipid hydroperoxides level in patients with leiomyoma are influenced by changes in sex hormones and gonadotropins (estradiol (E2), progesterone, FSH, and LH) during menstrual cycle and in postmenopause. The material consisted of blood and uterine tissue specimens. Hormone concentrations were determined and assays for superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities and lipid hydroperoxides concentration were performed. In blood of examined women, a significant difference in catalase, glutathione peroxidase and glutathione reductase activity was recorded among the phases. There was also a positive correlation between the estradiol\/progesterone concentration and the catalase activity. Progesterone negatively correlated with lipid hydroperoxides level. In myoma tissue, we recorded a phase-related difference in lipid hydroperoxides level and activities of superoxide dismutase, glutathione peroxidase activities, and glutathione reductase. Negative correlation was observed between FSH and glutathione peroxidase. The results suggest that antioxidant status in patients with uterine leiomyoma is influenced by the changes in sex hormones during the menstrual cycle and in postmenopause, indicating a role of the observed relationship in the leiomyoma etiology.<\/jats:p>","DOI":"10.1590\/0001-3765201520130416","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T17:58:47Z","timestamp":1489600727000},"page":"1771-1782","source":"Crossref","is-referenced-by-count":11,"title":["Antioxidant status in women with uterine leiomyoma: relation with sex hormones"],"prefix":"10.1590","volume":"87","author":[{"given":"SNE\u017dANA","family":"PEJI\u0106","sequence":"first","affiliation":[{"name":"\"Vin\u010da\" Institute of Nuclear Sciences, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANA","family":"TODOROVI\u0106","sequence":"additional","affiliation":[{"name":"\"Vin\u010da\" Institute of Nuclear Sciences, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VESNA","family":"STOJILJKOVI\u0106","sequence":"additional","affiliation":[{"name":"\"Vin\u010da\" Institute of Nuclear Sciences, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LJUBICA","family":"GAVRILOVI\u0106","sequence":"additional","affiliation":[{"name":"\"Vin\u010da\" Institute of Nuclear Sciences, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NATA\u0160A","family":"POPOVI\u0106","sequence":"additional","affiliation":[{"name":"\"Vin\u010da\" Institute of Nuclear Sciences, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SNE\u017dANA B.","family":"PAJOVI\u0106","sequence":"additional","affiliation":[{"name":"\"Vin\u010da\" Institute of Nuclear Sciences, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"3","article-title":"Role of oxidative stress in female reproduction","volume":"14","author":"AGARWAL A","year":"2005","journal-title":"Reprod Biol Endocrinol"},{"key":"ref2","first-page":"936486","article-title":"Reactive oxygen species in health and disease","author":"ALFADDA AA","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.freeradbiomed.2013.01.034","article-title":"17-\u03b2-estradiol and steady-state concentrations of H2O2antiapoptotic effects in endometrial cells from patients with endometriosis","volume":"60","author":"ANDRADE SS ET AL","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/1097-4652(2000)9999:999<000::AID-JCP1040>3.0.CO;2-E","article-title":"17-b estradiol elicits an autocrine leiomyoma cell proliferationevidence for a stimulation of protein kinase-dependent pathway","volume":"186","author":"BARBARISI A","year":"2001","journal-title":"J Cell Physiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1080\/gye.15.4.298.303","article-title":"Serum lipid peroxide levels and erythrocyte glutathione peroxidase and superoxide dismutase activity in premenopausal and postmenopausal women","volume":"15","author":"BEDNAREK-TUPIKOWSKA G","year":"2001","journal-title":"Gynecol Endocrinol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/09513590412331272328","article-title":"Serum lipid peroxides and total antioxidant status in postmenopausal women on hormone replacement therapy","volume":"19","author":"BEDNAREK-TUPIKOWSKA G","year":"2004","journal-title":"Gynecol Endocrinol"},{"key":"ref7","series-title":"Red Cell Metabolism, a manual of biohemical methods","first-page":"105","volume-title":"Catalase","author":"BEUTLER E","year":"1982"},{"key":"ref8","first-page":"1170","article-title":"Leiomyomata uteriHormonal and molecular determinants of growth","volume":"99","author":"BLAKE RE","year":"2007","journal-title":"J Natl Med Assoc"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/humupd\/dmm020","article-title":"A review of hormonal changes during the menopausal transitionfocus on findings from the Melbourne women's midlife health project","volume":"13","author":"BURGER HG","year":"2007","journal-title":"Hum Reprod Update"},{"key":"ref10","first-page":"10348","article-title":"Catalase is regulated by ubiquitination and proteosomal degradation","volume":"42","author":"CAO C","year":"2003","journal-title":"Role of the c-Abl and Arg tyrosine kinases. Biochemistry"},{"key":"ref11","first-page":"1008","article-title":"Postmenopausal therapy reduces catalase activity and attenuates cardiovascular risk","volume":"99","author":"CASTANHO VS","year":"2012","journal-title":"Arq Bras Cardiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1155\/2013\/173184","article-title":"Uterine fibroidspathogenesis and interactions with endometrium and endomyometrial junction","volume":"2013","author":"CIAVATTINI A","year":"2013","journal-title":"Obstet Gynecol Int"},{"key":"ref13","first-page":"140","article-title":"The role of oxidative stress in menopause","volume":"4","author":"DOSHI SB","year":"2013","journal-title":"J Midlife Health"},{"key":"ref14","first-page":"1503","article-title":"Uterine fibroid tumorsDiagnosis and treatment","volume":"75","author":"EVANS P","year":"2007","journal-title":"Am Fam Physician"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1021\/tx100413v","article-title":"Factors affecting protein thiol reactivity and specificity in peroxide reduction","volume":"24","author":"FERRER-SUETA G","year":"2011","journal-title":"Chem Res Toxicol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1289\/ehp.5787","article-title":"Etiology and pathogenesis of uterine leiomyomasa review","volume":"111","author":"FLAKE GP","year":"2003","journal-title":"Environ Health Perspect"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/019262301301418900","article-title":"Uterine leiomyomasmechanisms of tumorigenesis","volume":"29","author":"HOUSTON KD","year":"2001","journal-title":"Toxicol Pathol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/molehr\/7.11.1085","article-title":"Comparative analysis of cyclin D1 and oestrogen receptor (\u03b1 and \u03b2) levels in human leiomyoma and adjacent myometrium","volume":"7","author":"KOV\u00c1CS KA","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/ar.20925","article-title":"Hydrogen peroxide induces G2cell cycle arrest and inhibits cell proliferation in osteoblasts","volume":"292","author":"LI M","year":"2009","journal-title":"Anat Rec"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"LOWRY OH","year":"1951","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0009-8981(03)00085-8","article-title":"Plasma TBARS, blood GSH concentrations, and erythrocyte antioxidant enzyme activities in regularly menstruating women with ovulatory and anovulatory menstrual cycles","volume":"331","author":"LUTOS\u0141AWSKA G","year":"2003","journal-title":"Clin Chim Acta"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/humupd\/dmh019","article-title":"Sex steroidal regulation of uterine leiomyoma growth and apoptosis","volume":"10","author":"MARUO T","year":"2004","journal-title":"Hum Reprod Update"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0010-7824(93)90026-4","article-title":"Antioxidant erythrocyte enzyme activities during oral contraception","volume":"47","author":"MASSAFRA C","year":"1993","journal-title":"Contraception"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/09513599609027982","article-title":"Changes in the erythrocyte antioxidant enzyme system during transdermal estradiol therapy for secondary amenorrhea","volume":"10","author":"MASSAFRA C","year":"1996","journal-title":"Gynecol Endocrinol"},{"key":"ref25","first-page":"173","article-title":"Effects of estradiol and medroxyp roges terone acetate treatment on erythrocyte antioxidant enzyme activities and malondialdehyde plasma levels in amenorrhoic women","volume":"82","author":"MASSAFRA C","year":"1997","journal-title":"J Clin Endocrinol Metabol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1365-2265.1998.00441.x","article-title":"Variations in erythrocyte antioxidant glutathione peroxidase activity during the menstrual cycle","volume":"49","author":"MASSAFRA C","year":"1998","journal-title":"Clin Endocrinol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1677\/joe.0.1670447","article-title":"Effects of estrogens and androgens on erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase activities during the menstrual cycle","volume":"167","author":"MASSAFRA C","year":"2000","journal-title":"J Endocrinol"},{"key":"ref28","series-title":"Leiomyoma of the Uterus","author":"NEUWIRTH R","year":"2008"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2353\/ajpath.2009.080804","article-title":"Reactive oxygen species controls endometriosis progression","volume":"175","author":"NG\u00d4 C","year":"2009","journal-title":"Am J Pathol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1590\/S0001-37652008000300011","article-title":"Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium","volume":"80","author":"PEJI\u0106 S","year":"2008","journal-title":"An Acad Bras Cienc"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/1477-7827-7-149","article-title":"Antioxidant enzymes and lipid peroxidation in endometrium of patients with polyps, myoma, hyperplasia and adenocarcinoma","volume":"23","author":"PEJI\u0106 S","year":"2009","journal-title":"Reprod Biol 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N","year":"1994","journal-title":"Adv Contra Deliv Syst"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/molehr\/6.2.178","article-title":"Induction of superoxide dismutase by decidualization in human endometrial stromal cells","volume":"6","author":"SUGINO N","year":"2000","journal-title":"Mol Hum Reprod"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/09513599509160203","article-title":"Transdermal estradiol and medroxyprogesterone acetate in hormone replacement therapy are both antioxidants","volume":"9","author":"TRANQUILLI AL","year":"1995","journal-title":"Gynecol Endocrinol"},{"key":"ref41","first-page":"64","article-title":"Status of antioxidant enzymes and trace metals in postmen opausal women","volume":"55","author":"VAISHALI S","year":"2005","journal-title":"J Obstet Gynecol India,"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/01.AOG.0000136079.62513.39","article-title":"Uterine myomasAn overview of development, clinical features, and management","volume":"104","author":"WALLACH EE","year":"2004","journal-title":"Obstet Gynecol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1530\/eje.0.1460447","article-title":"Down-regulation of proliferation and up-regulation of apoptosis by gonadotropin-releasing hormone agonist in cultured uterine leiomyoma cells","volume":"146","author":"WANG Y","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"ref44","first-page":"63","article-title":"Endovascular treatment of uterine fibroids","volume":"1","author":"WEINTRAUB JL","year":"2011","journal-title":"US Radiology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1055\/s-0030-1251482","article-title":"Receptor tyrosine kinases and their hormonal regulation in uterine 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